Surbhi Chouhan, Ph.D. Assistant Instructor School Medical School Department Lyda Hill Department of Bioinformatics Biography Download Curriculum Vitae Dr. Surbhi CHouhan is an Assistant Instructor in the Lyda Hill Department of Bioinformatics since 2024. She is also a member of the Cecil H. and Ida Green Center for Systems Biology. She works in the lab of Dr. Benjamin Nanes to elucidate the interplay between vimentin and keratins in the stability/plasticity balance in skin development, wound healing, and cancer. She earned her PhD from the National Centre for Cell Science, India, in 2017, researching the impact of metabolites on cancer cell signaling pathways. In 2018, she joined Washington University in St. Louis as a postdoctoral researcher, focusing on the roles of the non-receptor kinase ACK1 in mitochondrial metabolism and histone modifications in prostate cancer. Research Interest Cell signaling interplay between vimentin and keratins Kinase pathways, epigenetics, metabolism Plasticity dynamics in wound healing, skin development, & cancer Publications Featured Publications SHP2 as a primordial epigenetic enzyme expunges histone H3 pTyr-54 to amend androgen receptor homeostasis. Chouhan S, Sridaran D, Weimholt C, Luo J, Li T, Hodgson MC, Santos LN, Le Sommer S, Fang B, Koomen JM, Seeliger M, Qu CK, Yart A, Kontaridis MI, Mahajan K, Mahajan NP, Nat Commun 2024 Jul 15 1 5629 TNK2/ACK1-mediated phosphorylation of ATP5F1A (ATP synthase F1 subunit alpha) selectively augments survival of prostate cancer while engendering mitochondrial vulnerability. Chouhan S, Sawant M, Weimholt C, Luo J, Sprung RW, Terrado M, Mueller DM, Earp HS, Mahajan NP, Autophagy 2023 Mar 19 3 1000-1025 Histone H2A Lys130 acetylation epigenetically regulates androgen production in prostate cancer. Nguyen T, Sridaran D, Chouhan S, Weimholt C, Wilson A, Luo J, Li T, Koomen J, Fang B, Putluri N, Sreekumar A, Feng FY, Mahajan K, Mahajan NP, Nat Commun 2023 Jun 14 1 3357 Inhibiting ACK1-mediated phosphorylation of C-terminal Src kinase counteracts prostate cancer immune checkpoint blockade resistance. Sridaran D, Chouhan S, Mahajan K, Renganathan A, Weimholt C, Bhagwat S, Reimers M, Kim EH, Thakur MK, Saeed MA, Pachynski RK, Seeliger MA, Miller WT, Feng FY, Mahajan NP, Nat Commun 2022 Nov 13 1 6929 Role of TNFα and leptin signaling in colon cancer incidence and tumor growth under obese phenotype. Singh S, Mayengbam SS, Chouhan S, Deshmukh B, Ramteke P, Athavale D, Bhat MK, Biochim Biophys Acta Mol Basis Dis 2020 May 1866 5 165660 Sensitization of hepatocellular carcinoma cells towards doxorubicin and sorafenib is facilitated by glucosedependent alterations in reactive oxygen species, P-glycoprotein and DKK4. Chouhan S, Singh S, Athavale D, Ramteke P, Vanuopadath M, Nair BG, Nair SS, Bhat MK, J Biosci 2020 45 Hepatocellular carcinoma-associated hypercholesterolemia: involvement of proprotein-convertase-subtilisin-kexin type-9 (PCSK9). Athavale D, Chouhan S, Pandey V, Mayengbam SS, Singh S, Bhat MK, Cancer Metab 2018 6 16 Elevated circulatory levels of leptin and resistin impair therapeutic efficacy of dacarbazine in melanoma under obese state. Malvi P, Chaube B, Singh SV, Mohammad N, Vijayakumar MV, Singh S, Chouhan S, Bhat MK, Cancer Metab 2018 6 2 Resistin causes G1 arrest in colon cancer cells through upregulation of SOCS3. Singh S, Chouhan S, Mohammad N, Bhat MK, FEBS Lett 2017 May 591 10 1371-1382 Constitutively activated ERK sensitizes cancer cells to doxorubicin: Involvement of p53-EGFR-ERK pathway. Kumari R, Chouhan S, Singh S, Chhipa RR, Ajay AK, Bhat MK, J Biosci 2017 Mar 42 1 31-41 Results 1-10 of 11 1 2 Next Last Honors & Awards Postdoctoral Research AssociateshipAwarded by the Department of Surgery at the School of Medicine at Washington University, St. Louis, Missouri. (2018-2022) Senior Research FellowshipAwarded by the Council of Scientific & Industrial Research (CSIR), India. (2013-2016) Junior Research FellowshipAwarded by the Council of Scientific & Industrial Research (CSIR), India. (2011-2013) National Eligibility Test (NET) certificationAwarded by Council of Scientific & Industrial Research (CSIR) for the Junior Research Fellowship & Lectureship (2010-2010) Professional Associations/Affiliations Associate Editor, Section Editor (2017-2024) Topical Advisory Editor (2021-2024)
