
Asaithamby Aroumougame, Ph.D.
Associate Professor
Department Radiation Oncology
Graduate Programs Biomedical Engineering, Cancer Biology
Biography
Asaithamby Aroumougame (a.k.a. Thambi), Ph.D.
DEMOGRAPHIC AND PERSONAL INFORMATION
Current Appointment
Associate Professor
Department of Radiation Oncology
UT Southwestern Medical Center at Dallas
Contact Information
Division of Molecular Radiation Biology
Department of Radiation Oncology
2201 Inwood Road, NC7.126A
Dallas, TX 75390
Phone: 214-648-5175
E-mail: asaithamby.aroumougame.@utsouthwestern.edu
Education and Training
2000-2004: Postdoctoral Research Fellow, Lawrence Berkeley National Laboratory, Berkeley, California; Cancer Biology and DNA damage repair
1994-1999: Ph.D., Banaras Hindu University, India; Cellular and Molecular Biology
1993: M.Phil., Pondicherry University, India; Endocrinology
1992: M.S., Pondicherry University, India; Life Sciences
1990: B.S., Pondicherry University, India; Life Sciences
Professional Experience
2020-current: Associate Professor, Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, Texas.
2013-2020: Assistant Professor (Tenure-Accruing Track), Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, Texas.
2009-2013: Assistant Professor (Research Track), Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, Texas. Advisor: David J. Chen
2004-2008: Instructor (Junior Faculty), Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, Texas. Advisor: David J. Chen
2002-2004: Postdoctoral Fellow, Department of Life Sciences, Lawrence Berkeley National Laboratory, Berkeley, California. Advisor: David J. Chen
2000-2001: Postdoctoral Fellow, Department of Life Sciences, Lawrence Berkeley National Laboratory, Berkeley, California. Advisor: Shyamala G Harris (Deceased)
1994-1999: Graduate Student, University Grants Commission of India, Banaras Hindu University, Varanasi, Uttar Pradesh, India. Advisor: Mahendra K Thakur
Education
- Undergraduate
- Pondicherry University (1990), Animal Science
- Graduate School
- Pondicherry University (1992), Animal Science
- Graduate School
- Banaras Hindu University (1999), Molecular & Cell Biology
Research Interest
- DNA damage response signaling in carcinogenesis
- DNA repair factors in immune response and immunotherapy
- DNA replication in tumorigenesis
- Pathophysiology of Premature Aging Syndrome, specifically Werner Syndrome Protein
- Radiotherapy and heart damage
- Space radiation and Astronauts' health
Publications
Featured Publications
- Mitochondrial fatty acid utilization increases chromatin oxidative stress in cardiomyocytes
- Menendez-Montes I, Abdisalaam S, Xiao F, Lam NT, Mukherjee W, Szweda LI, Asaithamby A, Sadek HA PNAS 2021 118 34 2101674118
- Immunomodulatory Effects of Radiotherapy.
- Kumari S, Mukherjee S, Sinha D, Abdisalaam S, Krishnan S, Asaithamby A, Int J Mol Sci 2020 Oct 21 21
- Dysfunctional telomeres trigger cellular senescence mediated by cyclic GMP-AMP synthase.
- Abdisalaam S, Bhattacharya S, Mukherjee S, Sinha D, Srinivasan K, Zhu M, Akbay EA, Sadek HA, Shay JW, Aroumougame A, J. Biol. Chem. 2020 Jun
- Mitochondrial Substrate Utilization Regulates Cardiomyocyte Cell Cycle Progression.
- Cardoso AC, Lam NT, Savla JJ, Nakada Y, Pereira AHM, Elnwasany A, Menendez-Montes I, Ensley EL, Petric UB, Sharma G, Sherry AD, Malloy CR, Khemtong C, Kinter MT, Tan WLW, Anene-Nzelu CG, Foo RS, Nguyen NUN, Li S, Ahmed MS, Elhelaly WM, Abdisalaam S, Asaithamby A, Xing C, Kanchwala M, Vale G, Eckert KM, Mitsche MA, McDonald JG, Hill JA, Huang L, Shaul PW, Szweda LI, Sadek HA, Nat Metab 2020 Feb 2 2 167-178
- Isolation of time-dependent DNA damage induced by energetic carbon ions and their fragments using fluorescent nuclear track detectors.
- McFadden CH, Rahmanian S, Flint DB, Bright SJ, Yoon DS, O'Brien DJ, Asaithamby A, Abdollahi A, Greilich S, Sawakuchi GO, Med Phys 2020 Jan 47 1 272-281
- NBS1-CtIP?Mediated DNA End Resection Regulates cGAS Binding to Micronuclei
- Abdisalaam S, Mukherjee S, Bhattacharya S, Sinha D, Kumari S, Sadek HA, Ortega J, Li GM, Asaithamby A. bioRxiv 2020
- Nonhomologous End Joining Is More Important Than Proton Linear Energy Transfer in Dictating Cell Death.
- Bright SJ, Flint DB, Chakraborty S, McFadden CH, Yoon DS, Bronk L, Titt U, Mohan R, Grosshans DR, Sumazin P, Shaitelman SF, Asaithamby A, Sawakuchi GO, Int J Radiat Oncol Biol Phys 2019 12 105 5 1119-1125
- Tumor treating fields cause replication stress and interfere with DNA replication fork maintenance: Implications for cancer therapy.
- Karanam NK, Ding L, Aroumougame A, Story MD, Transl Res 2019 Oct
- DNA Damage Response Mediates Pressure Overload-Induced Cardiomyocyte Hypertrophy.
- Nakada Y, Nhi Nguyen NU, Xiao F, Savla JJ, Lam NT, Abdisalaam S, Bhattacharya S, Mukherjee S, Asaithamby A, Gillette TG, Hill JA, Sadek HA Circulation 2019 Feb 139 9 1237-1239
- Mechanistic link between DNA damage sensing, repairing and signaling factors and immune signaling.
- Mukherjee S, Abdisalaam S, Bhattacharya S, Srinivasan K, Sinha D, Asaithamby A Adv Protein Chem Struct Biol 2019 115 297-324
Professional Associations/Affiliations
- Radiation Research Society (2012)