Asaithamby Aroumougame, Ph.D.
Associate Professor

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Asaithamby Aroumougame (a.k.a. Thambi), Ph.D.                                  

DEMOGRAPHIC AND PERSONAL INFORMATION

Current Appointment

Associate Professor
Department of Radiation Oncology
UT Southwestern Medical Center at Dallas

Contact Information

Division of Molecular Radiation Biology
Department of Radiation Oncology
2201 Inwood Road, NC7.126A                                                                       
Dallas, TX 75390                                                                               
Phone: 214-648-5175
E-mail: asaithamby.aroumougame.@utsouthwestern.edu

Education and Training

2000-2004: Postdoctoral Research Fellow, Lawrence Berkeley National Laboratory, Berkeley, California; Cancer Biology and DNA damage repair

1994-1999: Ph.D., Banaras Hindu University, India; Cellular and Molecular Biology

1993: M.Phil., Pondicherry University, India; Endocrinology

1992: M.S., Pondicherry University, India; Life Sciences

1990: B.S., Pondicherry University, India; Life Sciences

Professional Experience

2020-current: Associate Professor, Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, Texas. 

2013-2020: Assistant Professor (Tenure-Accruing Track), Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, Texas.

2009-2013: Assistant Professor (Research Track), Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, Texas. Advisor: David J. Chen

2004-2008: Instructor (Junior Faculty), Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, Texas. Advisor: David J. Chen

2002-2004: Postdoctoral Fellow, Department of Life Sciences, Lawrence Berkeley National Laboratory, Berkeley, California. Advisor: David J. Chen

2000-2001: Postdoctoral Fellow, Department of Life Sciences, Lawrence Berkeley National Laboratory, Berkeley, California. Advisor: Shyamala G Harris (Deceased)

1994-1999: Graduate Student, University Grants Commission of India, Banaras Hindu University, Varanasi, Uttar Pradesh, India. Advisor: Mahendra K Thakur

Undergraduate

Pondicherry University (1990), Animal Science

Graduate School

Pondicherry University (1992), Animal Science

Graduate School

Banaras Hindu University (1999), Molecular & Cell Biology

• DNA damage response signaling in carcinogenesis
• DNA repair factors in immune response and immunotherapy
• DNA replication in tumorigenesis
• Pathophysiology of Premature Aging Syndrome, specifically Werner Syndrome Protein
• Radiotherapy and heart damage
• Space radiation and Astronauts' health

Featured Publications

Mitochondrial fatty acid utilization increases chromatin oxidative stress in cardiomyocytes

Menendez-Montes I, Abdisalaam S, Xiao F, Lam NT, Mukherjee W, Szweda LI, Asaithamby A, Sadek HA PNAS 2021 118 34 2101674118

Immunomodulatory Effects of Radiotherapy.

Kumari S, Mukherjee S, Sinha D, Abdisalaam S, Krishnan S, Asaithamby A, Int J Mol Sci 2020 Oct 21 21

Dysfunctional telomeres trigger cellular senescence mediated by cyclic GMP-AMP synthase.

Abdisalaam S, Bhattacharya S, Mukherjee S, Sinha D, Srinivasan K, Zhu M, Akbay EA, Sadek HA, Shay JW, Aroumougame A, J. Biol. Chem. 2020 Jun

Mitochondrial Substrate Utilization Regulates Cardiomyocyte Cell Cycle Progression.

Cardoso AC, Lam NT, Savla JJ, Nakada Y, Pereira AHM, Elnwasany A, Menendez-Montes I, Ensley EL, Petric UB, Sharma G, Sherry AD, Malloy CR, Khemtong C, Kinter MT, Tan WLW, Anene-Nzelu CG, Foo RS, Nguyen NUN, Li S, Ahmed MS, Elhelaly WM, Abdisalaam S, Asaithamby A, Xing C, Kanchwala M, Vale G, Eckert KM, Mitsche MA, McDonald JG, Hill JA, Huang L, Shaul PW, Szweda LI, Sadek HA, Nat Metab 2020 Feb 2 2 167-178

Isolation of time-dependent DNA damage induced by energetic carbon ions and their fragments using fluorescent nuclear track detectors.

McFadden CH, Rahmanian S, Flint DB, Bright SJ, Yoon DS, O'Brien DJ, Asaithamby A, Abdollahi A, Greilich S, Sawakuchi GO, Med Phys 2020 Jan 47 1 272-281

NBS1-CtIP?Mediated DNA End Resection Regulates cGAS Binding to Micronuclei

Abdisalaam S, Mukherjee S, Bhattacharya S, Sinha D, Kumari S, Sadek HA, Ortega J, Li GM, Asaithamby A. bioRxiv 2020

Nonhomologous End Joining Is More Important Than Proton Linear Energy Transfer in Dictating Cell Death.

Bright SJ, Flint DB, Chakraborty S, McFadden CH, Yoon DS, Bronk L, Titt U, Mohan R, Grosshans DR, Sumazin P, Shaitelman SF, Asaithamby A, Sawakuchi GO, Int J Radiat Oncol Biol Phys 2019 12 105 5 1119-1125

Tumor treating fields cause replication stress and interfere with DNA replication fork maintenance: Implications for cancer therapy.

Karanam NK, Ding L, Aroumougame A, Story MD, Transl Res 2019 Oct

DNA Damage Response Mediates Pressure Overload-Induced Cardiomyocyte Hypertrophy.

Nakada Y, Nhi Nguyen NU, Xiao F, Savla JJ, Lam NT, Abdisalaam S, Bhattacharya S, Mukherjee S, Asaithamby A, Gillette TG, Hill JA, Sadek HA Circulation 2019 Feb 139 9 1237-1239

Mechanistic link between DNA damage sensing, repairing and signaling factors and immune signaling.

Mukherjee S, Abdisalaam S, Bhattacharya S, Srinivasan K, Sinha D, Asaithamby A Adv Protein Chem Struct Biol 2019 115 297-324

• Radiation Research Society (2012)