Todd Soesbe, Ph.D.

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Dr. Todd C. Soesbe joined the faculty at the Department of Radiology in July of 2015. He received his Bachelors degree in Physics from Clark University (Worcester, Massachusetts) in 1993. While at Clark, Dr. Soesbe performed several years of undergraduate research with a joint Physics and Chemistry research group lead by Dr. Christopher Landee and Dr. Mark Turnbull. This group designed and synthesized complexes containing transition metals chelated to organic ligands in order to investigate new forms of molecular magnetism, specifically bi-metallic ferrimagnetic materials.

After Clark University, Dr. Soesbe entered Physics graduate school at the University of Texas at Austin in 1997 where he received his Masters in Applied Physics degree in 2000. While at UT Austin, Dr. Soesbe worked with Dr. Karol Lang of the High Energy Physics department on the MINOS project (Main Injector Neutrino Oscillation Search) taking place at Fermilab National Laboratory (Batavia, Illinois). While performing neutrino detector research at UT Austin, Dr. Soesbe became very interested in applying novel high energy physics detector technologies to medical imaging, specifically high-pressure xenon proportional counters for large-volume gamma ray detection in SPECT applications.

From 2000 to 2002, Dr. Soesbe worked for the Optical Networking Division of Lucent Technologies (Richardson, Texas) where he helped develop and test optically based communication technologies for national and global medical data networking. In 2002, Dr. Soesbe returned to graduate school at the University of Texas Southwestern Medical Center at Dallas where he received his Ph.D. in Radiological Sciences in 2007. His graduate research at UT Southwestern, under the guidance of Dr. Peter Antich, focused on the design and development of a small animal SPECT detector that used micro-columnar CsI(Tl) crystals and an electron-multiplying CCD camera for gamma ray detection with photon counting. Dr. Soesbe received a Young Investigator Award for this research from the American Association of Physicists in Medicine in 2007.

Dr. Soesbe spent his post-doctoral years at the Advanced Imaging Research Center where his research involved creating new exogenous contrast agents for molecular imaging applications using MRI. Specifically, for the early detection and diagnosis of cancer. These agents included diamagnetic and paramagnetic chemical exchange saturation transfer agents (DIACEST and PARACEST, respectively), paramagnetic T₂ exchange contrast agents, and liposome nanoparticles containing proton shifting agents such as TmDOTMA. He was also involved in the design and fabrication of surface and volume coils for pre-clinical and clinical MRI studies as well as software development for imaging protocols and data analysis.

Dr. Soesbe’s current research at the Departmtent of Radiology involves clinical applications of spectral CT technologies including dual-energy, dual-detector, and photon-counting modalities.

Undergraduate

Clark University (1993), Physics

Graduate School

University of Texas at Austin (2000)

Graduate School

UT Southwestern Medical Center (2007)

• Clinical Spectral CT methods and applications
• In vivo imaging of CEST and PARACEST MR contrast agents
• In vivo imaging of liposomal agents using MR
• MR probe design and construction
• Preclinical SPECT detector design and construction

Featured Publications

Differentiating unexpected hyperattenuating intraluminal material from gastrointestinal bleeding on contrast enhanced dual-energy CT.

Soesbe TC, Ananthakrishnan L, Lewis MA, Radiol Case Rep 2021 Dec 16 12 3662-3665

Investigating new CT contrast agents: a phantom study exploring quantification and differentiation methods for high-Z elements using dual-energy CT.

Soesbe TC, Xi Y, Nasr K, Leyendecker JR, Lenkinski RE, Lewis MA, Eur Radiol 2021 Apr

A Technique to Identify Isoattenuating Gallstones with Dual-Layer Spectral CT: An ex Vivo Phantom Study.

Soesbe TC, Lewis MA, Xi Y, Browning T, Ananthakrishnan L, Fielding JR, Lenkinski RE, Leyendecker JR, Radiology 2019 Aug 292 2 400-406

Separating High-Z Oral Contrast From Intravascular Iodine Contrast in an Animal Model Using Dual-Layer Spectral CT.

Soesbe TC, Lewis MA, Nasr K, Ananthakrishnan L, Lenkinski RE Acad Radiol 2018 Oct

Pseudoenhancement effects on iodine quantification from dual-energy spectral CT systems: A multi-vendor phantom study regarding renal lesion characterization.

Soesbe TC, Ananthakrishnan L, Lewis MA, Duan X, Nasr K, Xi Y, Abbara S, Leyendecker JR, Lenkinski RE Eur J Radiol 2018 Aug 105 125-133

Maximizing T2 -exchange in Dy(3+) DOTA-(amide)X chelates: Fine-tuning the water molecule exchange rate for enhanced T2 contrast in MRI.

Soesbe TC, Ratnakar SJ, Milne M, Zhang S, Do QN, Kovacs Z, Sherry AD Magn Reson Med 2014 Jan

Advantages of paramagnetic chemical exchange saturation transfer (CEST) complexes having slow to intermediate water exchange properties as responsive MRI agents.

Soesbe TC, Wu Y, Dean Sherry A NMR Biomed 2012 Oct

SWIFT-CEST: A new MRI method to overcome T(2) shortening caused by PARACEST contrast agents.

Soesbe TC, Togao O, Takahashi M, Sherry AD Magn Reson Med 2012 Sep 68 3 816-21

T(2) exchange agents: A new class of paramagnetic MRI contrast agent that shortens water T(2) by chemical exchange rather than relaxation.

Soesbe TC, Merritt ME, Green KN, Rojas-Quijano FA, Sherry AD Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2011 May

High-resolution photon counting using a lens-coupled EMCCD gamma camera

Soesbe TC, Lewis MA, Slavine NV, Richer E, Bonte FJ, Antich PP IEEE Transactions on Nuclear Science 2010 3 57

• The European Society of Radiology
  Best Scientific Paper Presentation Award (2019)
• The Society of Abdominal Radiology
  Best Hot Topics in GI Scientific Paper Award (2019)
• The Society of Computed Body Tomography & Magnetic Resonance
  Hounsfield Award (2018)
• The Society of Computed Body Tomography & Magnetic Resonance
  Hounsfield Award (2017)
• The Society of Computed Body Tomography & Magnetic Resonance
  Hounsfield Award (2016)
• The American Association of Physicists in Medicine
  Young Investigator Award (2007)
• Department of Radiology, UT Southwestern Medical Center
  Fellowship (2005)
• Department of Physics, Clark University
  Honors in Physics (1993)
• Clark University
  Dean's List (1990)
• Clark University
  Alumni & Friends Scholarship (1989)

• The Society of Abdominal Radiology (SAR) (2017)
• The Society of Computed Body Tomography and Magnetic Resonance (SCBT-MR) (2016)
• American Association of Physicists in Medicine (AAPM)
• International Society for Magnetic Resonance in Medicine (ISMRM)
• Radiological Society of North America (RSNA)
• Society of Computed Body Tomography & Magnetic Resonance (SCBTMR)
• Society of Nuclear Medicine and Molecular Imaging (SNMMI)