Ronald Taussig, Ph.D. Associate Professor School Medical School Department Pharmacology Graduate Programs Cell and Molecular Biology Biography I received my bachelor’s degree from Columbia College in 1979 and my PhD in biology from Stanford University in 1988. During my postdoctoral research here in the Department of Pharmacology at UT Southwestern, my interest in signal transduction was focused on cell signaling mechanisms mediated by heterotrimeric G proteins. In 1994, I joined the Department of Biological Chemistry at the University of Michigan Medical Center, where I initiated genetic studies on the hormone regulated adenylyl cyclase system. Following my promotion to associate professor in 2001, I moved back to Dallas, joining the UT Southwestern Pharmacology faculty. My laboratory continues our long-established interest in understanding signal transduction processes regulated by heterotrimeric G proteins, with the primary focus of our research being the hormone regulated adenylyl cyclase system. These studies utilize a combination of molecular biology, biochemical and genetic approaches. Our most recent efforts have focused on determining the involvement of adenylyl cyclase mutations in pathophysiological states and examining the oncogenic potential of activating mutant adenylyl cyclase alleles. In addition to my laboratory research interests, I am the associate director of the Alliance for Cellular Signaling, a multi-institutional effort based here at UT Southwestern that is aimed at understanding signaling networks in mouse macrophages. Education Undergraduate Columbia College (1979) Graduate School Stanford University (1988) Research Interest Regulation of mammalian adenylyl cyclases Signal transduction by heterotrimeric G proteins Publications Featured Publications Isoforms of Mammalian Adenylyl Cyclase: Multiplicities of Signaling Sunahara, R.K. and Taussig, R. Mol. Interv. 2002 2 168-184 Activating Mutation of Adenylyl Cyclase Reverses its Inhibition by G Proteins Zimmermann, G., Zhou, D. and Taussig, R. Mol. Pharmacol. 1999 56 895-901 Genetic Selection of Mammalian Adenylyl Cyclases Insensitive to Stimulation by Gs-Alpha Zimmermann , G., Zhou, D. and Taussig, R. J. Biol. Chem. 1998 273 6968-6975 Protein Kinase C Alters the Responsiveness of Adenylyl Cyclases to G Protein Alpha and Beta-Gamma Subunits Zimmermann, G. and Taussig, R. J. Biol. Chem. 1996 271 27161-27166 Inhibition of Adenylyl Cyclase by Gi-Alpha Taussig, R., Iniguez-Lluhi, J.A. and Gilman, A.G. Science 1993 261 218-221 Genetic Selection of Regulatory Mutants of Mammalian Adenylyl Cyclases Clapp, P.A., Capper, A.B. and Taussig, R. Meth. Enzymol. 2002 345 241-251 Isoforms of Mammalian Adenylyl Cyclase: Multiplicities of Signaling Sunahara, R.K. and Taussig, R. Mol. Interv. 2002 2 168-184 G Protein Beta Subunit Types Differentially Interact with a Muscarinic Receptor but not Adenylyl Cyclase Type II or Phospholipase C-Beta 2/3 Hou, Y., Chang, V., Capper, A., Taussig, R. and Gautam, N. J. Biol. Chem. 2001 276 19982-19988 Evidence that a Protein-Protein Interaction "Hot Spot" is Used for Multiple Effector Recognition on Heterotrimeric G Protein Beta-Gamma Subunits Scott, J.K., Huang, S.F., Gangadhar, B.P., Samorisky, G.M., Clapp, P., Gross, R.A., Taussig, R.and Smrcka, A.V. EMBO J. 2001 20 767-776 Dopamine D2 Receptor-Induced Heterologous Sensitization of Adenylate Cyclase Requires G Alpha s: Characterization of G Alpha s-Insensitive Mutants of Adenylate Cyclase V Watts, V.J., Taussig, R., Neve, R.L. and Neve, K.A. Mol. Pharmacol. 2001 60 1168-1172 Results 1-10 of 10 1 Honors & Awards Burroughs Wellcome New Investigator AwardBurroughs Wellcome Award in the Pharmacological Sciences (1997) Fellowship AwardMerck Sharp & Dohme Research Laboratories (1988) Professional Associations/Affiliations ASBMB ASPET International Human Proteomics Organization (HUPO), Council Member, Editorial Board, Journal of Biological Chemistry Study Section, American Heart Association
