Dr. Blount's research is aimed at determining molecular, biochemical, and biophysical mechanisms underlying an organisms’ ability to detect mechanical forces. Such mechanosensation is necessary not only in our sense of touch, but in the ear for hearing and balance, as well as cardiovascular regulation. Because of its tractability and simplicity, he has primarily studied mechanosensitive channels in bacteria.
Dr. Blount’s laboratory utilizes a multidisciplinary approach that includes microbial genetics, biochemical, biophysical and electrophysiological approaches to explore the general functional principles of biological mechanosensors.
His work has also recently expanded to include investigating the potential use of bacterial mechanosensors as potential drug targets, developing them into ‘triggered nanovalves’ that could be used in drug-release devices or “smart” contrasts for MRI, and the biophysical characterization of candidate mammalian mechanosensitive channels.
- University of California-San D (1983)
- Graduate School
- Washington University (1990)
- Bacterial channels
- mechanosensitive channels
- Microbial homeostasis
- Life with Bacterial Mechanosensitive Channels, from Discovery to Physiology to Pharmacological Target.
- Blount P, Iscla I, Microbiol. Mol. Biol. Rev. 2020 Feb 84 1
- Novel MscL agonists that allow multiple antibiotics cytoplasmic access activate the channel through a common binding site.
- Wray R, Wang J, Iscla I, Blount P, PLoS ONE 2020 15 1 e0228153
- An agonist of the MscL channel affects multiple bacterial species and increases membrane permeability and potency of common antibiotics.
- Wray R, Herrera N, Iscla I, Wang J, Blount P, Mol. Microbiol. 2019 Jun
- Interaction of the Mechanosensitive Channel, MscS, with the Membrane Bilayer through Lipid Intercalation into Grooves and Pockets.
- Rasmussen T, Rasmussen A, Yang L, Kaul C, Black S, Galbiati H, Conway SJ, Miller S, Blount P, Booth IR, J. Mol. Biol. 2019 Jun
- Human mutations highlight an intersubunit cation-p bond that stabilizes the closed but not open or inactivated states of TRPV channels.
- Teng J, Anishkin A, Kung C, Blount P, Proc. Natl. Acad. Sci. U.S.A. 2019 Apr
- Effects of Low Intensity Focused Ultrasound on Liposomes Containing Channel proteins.
- Babakhanian M, Yang L, Nowroozi B, Saddik G, Boodaghians L, Blount P, Grundfest W Sci Rep 2018 Nov 8 1 17250
- Novel compounds that specifically bind and modulate MscL: insights into channel gating mechanisms.
- Wray R, Iscla I, Kovacs Z, Wang J, Blount P FASEB J. 2018 Oct fj201801628R
- Engineering a pH-Sensitive Liposomal MRI Agent by Modification of a Bacterial Channel.
- Yang LM, Zheng H, Ratnakar JS, Adebesin BY, Do QN, Kovacs Z, Blount P Small 2018 Apr e1704256
- Dihydrostreptomycin Directly Binds to, Modulates, and Passes through the MscL Channel Pore.
- Wray R, Iscla I, Gao Y, Li H, Wang J, Blount P PLoS Biol. 2016 Jun 14 6 e1002473
- A new antibiotic with potent activity targets MscL.
- Iscla I, Wray R, Blount P, Larkins-Ford J, Conery AL, Ausubel FM, Ramu S, Kavanagh A, Huang JX, Blaskovich MA, Cooper MA, Obregon-Henao A, Orme I, Tjandra ES, Stroeher UH, Brown MH, Macardle C, van Holst N, Ling Tong C, Slattery AD, Gibson CT, Raston CL, Boulos RA J. Antibiot. 2015 Feb
MscL: The bacterial mechanosensitive channel of large conductance. In Mechanosensitive Ion Channels (a volume in the Current Topics in Membranes series)
Blount, P., Iscla, I., Moe, P. C. Li, Y. (2007). St. Louis, MO, Elsievier Press
Mechanosensitive channels gated by membrane tension: Bacteria and beyond.. In Mechanosensitive ion channels (a volume in the Mechanosensitivity in Cells and Tissues, Moscow Academia series)
Blount, P., Li, Y., Moe, P. C., Iscla, I. (2008). New York, Springer Press
- Member of the American Society for Microbiology
- Member of the Biophysical Society