Andrew Clark, Ph.D.

Andrew Clark, PhD, D(ABMM) is the Associate Director of Microbiology at Clements University Hospital at the University of Texas Southwestern Medical Center.  He is also an assistant professor in the Department of Pathology. 

Dr. Clark received his undergraduate, masters, and doctoral degrees in Microbiology from the University of Arizona, Tucson AZ.  He then completed a CPEP-accredited postdoctoral fellowship training program in Clinical and Public Health Microbiology at the National Institutes of Health in Bethesda, MD.  Dr. Clark is board certified in Medical and Public Health Microbiology by the American Board of Medical Microbiology.  His research and academic interests are focused on the molecular mechanisms of antimicrobial resistance and antimicrobial susceptibility testing in the clinical microbiology laboratory.  He is also interested in the pathophysiology and antimicrobial resistance of anaerobic bacteria, and the evaluation and implementation of novel diagnostic technologies.

Undergraduate School

University of Arizona (2006)

Graduate School

University of Arizona (2009)

Graduate School

University of Arizona (2017)

Fellowship

National Institutes of Health (NIH) (2019)

• Antimicrobial resistance mechanisms and pathophysiology of anaerobic bacteria
• Antimicrobial susceptibility testing
• Evaluation of diagnostic technologies and diagnostic test utilization in the clinical microbiology laboratory

Featured Publications

Roving methyltransferases generate a mosaic epigenetic landscape and influence evolution in Bacteroides fragilis group.

Tisza MJ, Smith DDN, Clark AE, Youn JH, Khil PP, Dekker JP, Nat Commun 2023 Jul 14 1 4082

Clinically undetected polyclonal heteroresistance among Pseudomonas aeruginosa isolated from cystic fibrosis respiratory specimens.

Maxwell DN, Kim J, Pybus CA, White L, Medford RJ, Filkins LM, Monogue ML, Rae MM, Desai D, Clark AE, Zhan X, Greenberg DE, J Antimicrob Chemother 2022 Oct

Multiplex Fragment Analysis for Flexible Detection of All SARS-CoV-2 Variants of Concern.

Clark AE, Wang Z, Ostman E, Zheng H, Yao H, Cantarel B, Kanchwala M, Xing C, Chen L, Irwin P, Xu Y, Oliver D, Lee FM, Gagan JR, Filkins L, Muthukumar A, Park JY, Sarode R, SoRelle JA, Clin Chem 2022 May

The Alternative Sigma Factor SigL Influences Clostridioides difficile Toxin Production, Sporulation, and Cell Surface Properties.

Clark AE, Adamson CC, Carothers KE, Roxas BAP, Viswanathan VK, Vedantam G, Front Microbiol 2022 13 871152

In vitro activity of cefiderocol against Pseudomonas aeruginosa isolated from cystic fibrosis patients.

Monogue ML, Desai D, Pybus CA, Sanders JM, Clark AE, Greenberg DE, Microbiol Spectr 2023 Nov e0304723

Limited Clinical Utility of Routine Mycobacterial Cultures for the Management of Diabetic Foot Infections.

Castellino LM, McCormick-Baw C, Coye T, Crisologo PA, Hanna JJ, Lee F, Clark A, Fanning M, Killeen AL, Open Forum Infect Dis 2023 Nov 10 11 ofad558

A conceptual framework for nomenclatural stability and validity of medically important fungi: a proposed global consensus guideline for fungal name changes supported by ABP, ASM, CLSI, ECMM, ESCMID-EFISG, EUCAST-AFST, FDLC, IDSA, ISHAM, MMSA, and MSGERC.

de Hoog S, Walsh TJ, Ahmed SA, Alastruey-Izquierdo A, Alexander BD, Arendrup MC, Babady E, Bai F-Y, Balada-Llasat J-M, Borman A, Chowdhary A, Clark A, Colgrove RC, Cornely OA, Dingle TC, Dufresne PJ, Fuller J, Gangneux J-P, Gibas C, Glasgow H, Gräser Y, Guillot J, Groll AH, Haase G, Hanson K, Harrington A, Hawksworth DL, Hayden RT, Hoenigl M, Hubka V, Johnson K, Kus JV, Li R, Meis JF, Lackner M, Lanternier F, Leal SM, Lee F, Lockhart SR, Luethy P, Martin I, Kwon-Chung KJ, Meyer W, Nguyen MH, Ostrosky-Zeichner L, Palavecino E, Pancholi P, Pappas PG, Procop GW, Redhead SA, Rhoads DD, Riedel S, Stevens B, Sullivan KO, Vergidis P, Roilides E, Seyedmousavi A, Tao L, Vicente VA, Vitale RG, Wang Q-M, Wengenack NL, Westblade L, Wiederhold N, White L, Wojewoda CM, Zhang SX, J Clin Microbiol 2023 Oct e0087323

Ceftolozane/tazobactam heteroresistance in cystic fibrosis-related Pseudomonas aeruginosa infections.

Monogue ML, Sanders JM, Pybus CA, Kim J, Zhan X, Clark AE, Greenberg DE, JAC Antimicrob Resist 2023 Aug 5 4 dlad083

Antimicrobial Activity of Tebipenem and Comparators against Enterobacterales from diverse Outpatient Centers and Nursing Homes in the United States.

Asempa TE, Bobenchik AM, Bourassa L, Clark AE, Hatch MT, Huse HK, Martin IW, Mochon AB, Munson E, Sfeir MM, Srodon M, Wang Y, Nicolau DP, Int J Antimicrob Agents 2023 Jan 106733

The Brief Case: Encephalitis in a West Texas Woman.

McCormick-Baw C, Clark A, Knights S, Perl T, Cavuoti D, J Clin Microbiol 2022 Nov 60 11 e0227121

 Featured Books

Anaerboic Bacteriology: 4.9: Rapid Biochemical Tests (4 Hours or Less) for the Identification of Anaerobes. In Clinical Microbiology Procedures Handbook

Margaret Ordonez-Smith de Danies and Andrew E. Clark (2023). Washington, DC, ASM Press

• American Society for Microbiology (2013)
• Anaerobe Society of the Americas (2021)
• Southwestern Association of Clinical Microbiology (2022)