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Sarah Sinnett, Ph.D.

Sarah Sinnett, Ph.D.

Assistant Professor

School
Medical School
Department
Pediatrics | Eugene McDermott Center for Human Growth and Development
Graduate Programs
Cell and Molecular Biology
  • Publications

    Star Featured Publications

    Engineered microRNA-based regulatory element permits safe high-dose miniMECP2 gene therapy in Rett mice.
    Sinnett SE, Boyle E, Lyons C, Gray SJ, Brain 2021 May
    Gene Transfer Therapy for Neurodevelopmental Disorders.
    Ozlu C, Bailey RM, Sinnett S, Goodspeed KD, Dev Neurosci 2021 Apr 1-11
    Intellectual and Developmental Disabilities Research Centers: A Multidisciplinary Approach to Understand the Pathogenesis of Methyl-CpG Binding Protein 2-related Disorders.
    Fagiolini M, Patrizi A, LeBlanc J, Jin LW, Maezawa I, Sinnett S, Gray SJ, Molholm S, Foxe JJ, Johnston MV, Naidu S, Blue M, Hossain A, Kadam S, Zhao X, Chang Q, Zhou Z, Zoghbi H, Neuroscience 2020 10 445 190-206
    AAV-Mediated Gene Therapy in CNS Genetic Disorders
    Casy W, Ling Q, Shaffo FC, Sinnett SE, Gray SJ. Rosenberg?s Molecular and Genetic Basis of Neurological and Psychiatric Disease 2020 Sixth Edition
    Recent endeavors in MECP2 gene transfer for gene therapy of Rett syndrome.
    Sinnett SE, Gray SJ Discov Med 2017 Oct 24 132 153-159
    Development of a Novel AAV Gene Therapy Cassette with Improved Safety Features and Efficacy in a Mouse Model of Rett Syndrome.
    Gadalla KKE, Vudhironarit T, Hector RD, Sinnett S, Bahey NG, Bailey MES, Gray SJ, Cobb SR Mol Ther Methods Clin Dev 2017 Jun 5 180-190
    Improved MECP2 Gene Therapy Extends the Survival of MeCP2-Null Mice without Apparent Toxicity after Intracisternal Delivery.
    Sinnett SE, Hector RD, Gadalla KKE, Heindel C, Chen D, Zaric V, Bailey MES, Cobb SR, Gray SJ Mol Ther Methods Clin Dev 2017 Jun 5 106-115
    The Role of AMPK in Drosophila melanogaster.
    Sinnett SE, Brenman JE, Exp Suppl 2016 107 389-401
    Past strategies and future directions for identifying AMP-activated protein kinase (AMPK) modulators.
    Sinnett SE, Brenman JE, Pharmacol. Ther. 2014 Jul 143 1 111-8
    A High Throughput Assay for Discovery of Small Molecules that Bind AMP-activated Protein Kinase (AMPK).
    Sinnett SE, Sexton JZ, Brenman JE, Curr Chem Genom Transl Med 2013 7 30-8
  • Honors & Awards
    • ASGCT Travel Award
      (2017)
    • Travel Award from UNC's Graduate Student Federation
      (2013)
  • Professional Associations/Affiliations
    • American Society of Gene & Cell Therapy, Associate Member (2015, 2017)