Download Curriculum Vitae

My long-term research goal is to understand the mechanisms of basic cellular processes and utilize this knowledge for betterment of human health. As a PhD student in the lab of Dr. Maddika Subbreddy at Center for DNA Fingerprinting and Diagnostics (CDFD) Hyderabad, India, I worked on the cellular ubiquitin proteasome system (UPS). The focus of my work was to identify non-canonical and novel roles of the UPS in cells and determine the importance of these processes in maintaining cell quality and overall organismal health. As an assistant instructor in the Mukhopadhyay lab, I am currently interested in studying the role of primary cilia in development and disease. Specifically, I am interested in understanding how proteins traffic to cilia and delineate the mechanisms involved in these processes. I am particularly interested in studying the role of ciliary trafficking with respect to ciliopathy phenotypes including renal cystogenesis.

Research Interest

  • Cellular Signaling
  • Posttranslational modifications including ubiquitination
  • primary cilia
  • Protein trafficking


Featured Publications LegendFeatured Publications

GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway.
Hoppe N, Harrison S, Hwang SH, Chen Z, Karelina M, Deshpande I, Suomivuori CM, Palicharla VR, Berry SP, Tschaikner P, Regele D, Covey DF, Stefan E, Marks DS, Reiter J, Dror RO, Evers AS, Mukhopadhyay S, Manglik A, bioRxiv 2023 May
Human IFT-A complex structures provide molecular insights into ciliary transport.
Jiang M, Palicharla VR, Miller D, Hwang SH, Zhu H, Hixson P, Mukhopadhyay S, Sun J, Cell Res 2023 Apr 33 4 288-298
Interactions between TULP3 tubby domain and ARL13B amphipathic helix promote lipidated protein transport to cilia.
Palicharla VR, Hwang SH, Somatilaka BN, Legué E, Shimada IS, Familiari NE, Tran VM, Woodruff JB, Liem KF, Mukhopadhyay S, Mol Biol Cell 2023 Mar 34 3 ar18
A pathogenic variant of TULP3 causes renal and hepatic fibrocystic disease.
Jafari Khamirani H, Palicharla VR, Dastgheib SA, Dianatpour M, Imanieh MH, Tabei SS, Besse W, Mukhopadhyay S, Liem KF, Front Genet 2022 13 1021037
Cilia-Localized Counterregulatory Signals as Drivers of Renal Cystogenesis.
Walker RV, Maranto A, Palicharla VR, Hwang SH, Mukhopadhyay S, Qian F, Front Mol Biosci 2022 9 936070
Ubiquitin-independent proteasomal degradation of Spindlin-1 by the E3 ligase HACE1 contributes to cell-cell adhesion.
Palicharla VR, Gupta D, Bhattacharya D, Maddika S, FEBS Lett 2021 Feb 595 4 491-506
Ankmy2 Prevents Smoothened-Independent Hyperactivation of the Hedgehog Pathway via Cilia-Regulated Adenylyl Cyclase Signaling.
Somatilaka BN, Hwang SH, Palicharla VR, White KA, Badgandi H, Shelton JM, Mukhopadhyay S, Dev Cell 2020 Sep 54 6 710-726.e8
Tulp3 Regulates Renal Cystogenesis by Trafficking of Cystoproteins to Cilia.
Hwang SH, Somatilaka BN, Badgandi H, Palicharla VR, Walker R, Shelton JM, Qian F, Mukhopadhyay S, Curr Biol 2019 Mar 29 5 790-802.e5
HACE1 mediated K27 ubiquitin linkage leads to YB-1 protein secretion.
Palicharla VR, Maddika S, Cell Signal 2015 Dec 27 12 2355-62
Interconnections between apoptotic, autophagic and necrotic pathways: implications for cancer therapy development.
Jain MV, Paczulla AM, Klonisch T, Dimgba FN, Rao SB, Roberg K, Schweizer F, Lengerke C, Davoodpour P, Palicharla VR, Maddika S, Los M, J Cell Mol Med 2013 Jan 17 1 12-29

Honors & Awards

  • ASCB travel grant
  • Postdoctoral fellowship from polycystic kidney disease (PKD) foundation.
  • Second best talk award at the FASEB SRC The Biology of Cilia and Flagella meeting
  • Society for Developmental biology (SDB) travel grant
  • International Travel Fellowship from Science and Engineering Research Board (SERB), India
  • Raman Charpak Indo French PhD exchange fellowship
  • Junior and Senior Research Fellowship from University Grants Commission, India
  • Summer Research Fellowship from Indian Academy of Sciences (IAS), India
  • Merit Fellowship from Department of Biotechnology (DBT), India