Samuel John, M.D.

Medical School

Albany Medical College (2011)

Residency

UT Southwestern/Children's Medical Center (2014), Pediatrics

Fellowship

UT Southwestern/Children's Medical Center (2017), Pediatric Hematology/oncology

• Acute myeloid leukemia
• Cell therapy
• Immunotherapy

Featured Publications

Leukocyte immunoglobulin-like receptor subfamily B: therapeutic targets in cancer.

Deng M, Chen H, Liu X, Huang R, He Y, Yoo B, Xie J, John S, Zhang N, An Z, Zhang CC, Antib Ther 2021 Jan 4 1 16-33

Leukocyte immunoglobulin-like receptor B1 and B4 (LILRB1 and LILRB4): Highly sensitive and specific markers of acute myeloid leukemia with monocytic differentiation.

Churchill HRO, Fuda FS, Xu J, Deng M, Zhang CC, An Z, Zhang N, Chen P, Bergstrom C, Kansagra A, Collins R, John S, Koduru P, Chen W, Cytometry B Clin Cytom 2020 Sep

Antagonistic anti-LILRB1 monoclonal antibody regulates antitumor functions of natural killer cells.

Chen H, Chen Y, Deng M, John S, Gui X, Kansagra A, Chen W, Kim J, Lewis C, Wu G, Xie J, Zhang L, Huang R, Liu X, Arase H, Huang Y, Yu H, Luo W, Xia N, Zhang N, An Z, Zhang CC, J Immunother Cancer 2020 08 8 2

CD19 CAR T Cells for the Treatment of Pediatric Pre-B Cell Acute Lymphoblastic Leukemia.

Pacenta HL, Laetsch TW, John S, Paediatr Drugs 2020 Feb 22 1 1-11

LILRB4 signalling in leukaemia cells mediates T cell suppression and tumour infiltration.

Deng M, Gui X, Kim J, Xie L, Chen W, Li Z, He L, Chen Y, Chen H, Luo W, Lu Z, Xie J, Churchill H, Xu Y, Zhou Z, Wu G, Yu C, John S, Hirayasu K, Nguyen N, Liu X, Huang F, Li L, Deng H, Tang H, Sadek AH, Zhang L, Huang T, Zou Y, Chen B, Zhu H, Arase H, Xia N, Jiang Y, Collins R, You MJ, Homsi J, Unni N, Lewis C, Chen GQ, Fu YX, Liao XC, An Z, Zheng J, Zhang N, Zhang CC Nature 2018 Oct 562 7728 605-609

A Novel Anti-LILRB4 CAR-T Cell for the Treatment of Monocytic AML.

John S, Chen H, Deng M, Gui X, Wu G, Chen W, Li Z, Zhang N, An Z, Zhang CC Mol. Ther. 2018 Aug

Inhibitory leukocyte immunoglobulin-like receptors: immune checkpoint proteins and tumor sustaining factors.

Kang X, Kim J, Deng M, John S, Chen H, Wu G, Phan H, Zhang CC Cell Cycle 2015 Dec 0

• Award for Clinical Excellence
  UT Southwestern/Children’s Medical Center (2014)
• Award for Clinical Excellence
  UT Southwestern/Children’s Medical Center (2013)
• Gold Humanism Honor Society Inductee
  (2011)

• American Academy of Pediatrics (2014)
• American Society of Clinical Oncology (2014)
• American Society of Hematology (2014)
• American Society of Pediatric Hematology- Oncology (2014)
• Children’s Oncology Group (2014)