Samuel John, M.D. Titles and Appointments Assistant Professor Schools Medical School Departments Pediatrics You have reached the Academic Profile. For more information on the doctor and patient care, please visit the clinical profile. Biography Samuel John, M.D., is an Assistant Professor in the Department of Pediatrics at UT Southwestern Medical Center and Attending physician in the Gill Center for Cancer and Blood Disorders at Children’s Medical Center in Dallas. He specializes in pediatric blood cancers, cellular therapy, and cancer immunotherapy. Dr. John earned his medical degree at Albany Medical College. He performed his residency in pediatrics at UT Southwestern and Children’s Medical Center, where he also completed a fellowship in pediatric hematology and oncology. He joined the UT Southwestern faculty in 2017. Dr. John serves as the CAR T-Cell Therapy Program leader for UT Southwestern and Children’s Medical Center. His clinical and research interests include cancer immunotherapies and cellular therapies, acute lymphoblastic leukemia (ALL), and acute myeloid leukemia (AML). He is the Principal Investigator at UT Southwestern for pediatric cell therapy clinical trials for leukemia and certain solid tumors. Dr. John’s joint research with Alec Zhang, Ph.D., has developed a novel CAR T-cell therapy for AML, which they are working to move into clinical trials. They are also developing CAR T-cells for other cancers, including both adult and pediatric solid tumors. Education Medical School Albany Medical College (2011) Residency UT Southwestern/Children's Medical Center (2014), Pediatrics Fellowship UT Southwestern/Children's Medical Center (2017), Pediatric Hematology/oncology Research Interest Acute myeloid leukemia Cell therapy Immunotherapy Publications Liberalizing hospital proximity requirements for children/young adults with low-burden B-ALL receiving tisagenlecleucel Appell LE, Baggott C, Nguyen K, Prabhu S, Pacenta H, John S, Fabrizio VA, Phillips CL, Rossoff J, Talano JA, Moskop A, Phelan R, Baumeister SH, Verneris MR, Hall EM, Myers GD, Karras NA, Cooper SL, Qayed M, Raikar SS, Winestone L, Hermiston M, Satwani P, Krupski C, Keating AK, Friedman DN, Curran KJ, Hoover A, MacMillan ML, Ebens CL, Ramgopal A, Rahrig AL, Mackall CL, Laetsch TW, McNerney K, Schultz LM Blood Advances 2026 Jan 10 106-110 Real-world outcomes of infections following tisagenlecleucel in patients with B-cell ALL: a CIBMTR analysis Rangarajan HG, Satwani P, Herr MM, Chen M, Martens MJ, Wudhikarn K, John S, Fabrizio VA, Hsieh EM, Kelkar AH, Doherty E, Marks DI, Ringden O, Friend B, Kelly MS, Farhadfar N, Prestidge T, Hossain NM, Liu H, Hashmi S, Modi D, Winestone LE, El Boghdadly Z, Murthy HS, Perales MA, Chemaly RF, Dandoy CE, Hill JA, Huppler A, Riches M, Auletta JJ Blood Advances 2025 Nov 9 5489-5500 Real-world data for tisagenlecleucel in patients with R/R B-ALL: subgroup analyses from the CIBMTR registry John S, Curran KJ, Hall EM, Keating AK, Baumeister SH, Nikiforow S, Driscoll T, Moskop A, McNerney KO, Phillips CL, Pulsipher MA, Hsieh EM, Rouce RH, Pasquini MC, Tiwari R, Willert J, Ramos R, Krueger J, Guest E, Grupp SA Blood Advances 2025 Oct 9 5249-5262 Characterization and prediction of prolonged severe neutropenia in pediatric patients receiving tisagenlecleucel Naik S, Selukar S, Talleur AC, Deshpande S, Llaurador Caraballo G, Fabrizio VA, Rouce RH, Zeng XL, Vatsayan A, Rossoff J, Pacenta HL, John S, Phillips CL, Talano JA, Moskop A, Verneris MR, Myers GD, Hall E, Karras N, Bonifant CL, Qayed M, Bakinowski E, Keating AK, Baumeister SH, Tomilson E, Hermiston ML, Satwani P, Krupski C, Chinnabhandar V, Stefanski HE, Egeler E, Curran KJ, Laetsch TW, Mackall CL, Prabhu S, Nguyen KP, Baggott C, Schultz LM, McNerney KO Blood Advances 2025 Oct 9 5070-5084 Project EVOLVE: an international analysis of postimmunotherapy lineage switch, an emergent form of relapse in leukemia Silbert SK, Rankin AW, Hoang CN, Semchenkova A, Myers RM, Zerkalenkova E, Wang HW, Kovach AE, Yuan CM, Delgado Colon D, Vasseur L, Bataller A, John S, Utley Lyons K, Friedes B, Alonso-Saladrigues A, Abdel-Azim H, Balducci E, Aljudi AA, Balsat M, Biery DN, Chamdin A, Chang BH, Cuevo RS, De Moerloose B, Dickens DS, Duffner U, Duployez N, El Chaer F, Elliott MA, Escherich G, Fernandes S, Fitzjohn MR, Gahvari Z, Grupp SA, He RR, Harrison C, Hergott CB, Hsieh EM, Kim AS, Kuo DJ, Larson DP, Lee BJ, Leguay T, Lindsley RC, Mangaonkar AA, Mezger K, Pacenta HL, Pan J, Provost M, Puri L, Raikar SS, Martinez A, Bristol I, Murphy K, Reiman L, Redell M, Reed K, Roth-Guepin G, Rubinstein J, Savaşan S, Schafernak K, Stevens A, Talleur A, Torres Carapia N, Vargaftig J, Vatsayan A, Wölfl M, Zhao L, Rives S, Fabrizio VA, Sasaki K, Aldoss I, Boissel N, Rheingold SR, Davis KL, Ghorashian S, Jacoby E, Popov A, Lamble AJ, Shah NN Blood 2025 Jul 146 437-455 Real-world outcomes for young adult patients receiving CD19 CAR T-cell therapy Lust H, Schultz LM, Kwon S, Roloff GW, Aldoss I, Baggott C, John S, Rossoff JE, McNerney KO, Fabrizio VA, Talano JA, Moskop A, Curran KJ, Phillips CL, Karras N, Baumeister SH, Cooper SL, Hermiston M, Satwani P, Qayed M, Raikar SS, MacMillan M, Hall E, Nguyen K, Cassaday RD, Kopmar NE, Kota VK, Mathews J, Shaughnessy P, Schwartz MS, Ladha A, Yaghmour G, Kumaran MV, Bachanova V, Tracy S, Othman T, Luskin MR, Chen EC, Advani AS, Jeyakumar N, Miller K, Zhang A, Sutherland KC, Shah BD, Muffly L, Faramand R Blood Advances 2025 Jun 9 2763-2772 Eph Receptors Activate Myeloid Checkpoint Receptor LILRB5 to Support Tumor Development He Y, Zhang C, Tan L, Deng M, Liu X, Huang R, Yang X, Xie J, Lou Q, Fang M, Smith C, John S, Xiong W, Li X, Lewis C, Homsi J, Gupta A, Zhang N, An Z, Zhang CC Cancer Immunology Research 2025 Jun 13 821-835 Genomic Landscape of Mixed Phenotype Acute Leukemia Associated With Immunophenotypic Lineage Predominance: Impact on Diagnosis and Treatment Zheng R, Gagan J, Botten GA, Koduru P, Weinberg OK, Chen M, Cantu MD, Jaso J, Germans S, Luu HS, Han L, Slone TL, Dickerson KE, John S, Madanat YF, Chung S, Collins R, Marinos A, Fuda F, Chen W European Journal of Haematology 2025 Jun 114 1041-1051 A Switch Protein Adapter for Anti-LILRB4 CAR-T Cells Huang R, Chen H, Xie J, Lou Q, Tan L, Zhang N, An Z, John S, Zhang CC European Journal of Immunology 2025 Feb 55 Bone-marrow-homing lipid nanoparticles for genome editing in diseased and malignant haematopoietic stem cells Lian X, Chatterjee S, Sun Y, Dilliard SA, Moore S, Xiao Y, Bian X, Yamada K, Sung YC, Levine RM, Mayberry K, John S, Liu X, Smith C, Johnson LT, Wang X, Zhang CC, Liu DR, Newby GA, Weiss MJ, Yen JS, Siegwart DJ Nature Nanotechnology 2024 Sep 19 1409-1417 Results 1-10 of 25 1 2 3 Next Last Honors & Awards Award for Clinical ExcellenceUT Southwestern/Childrens Medical Center (2014) Award for Clinical ExcellenceUT Southwestern/Childrens Medical Center (2013) Gold Humanism Honor Society Inductee (2011) Professional Associations/Affiliations American Academy of Pediatrics (2014) American Society of Clinical Oncology (2014) American Society of Hematology (2014) American Society of Pediatric Hematology- Oncology (2014) Childrens Oncology Group (2014)
