Chengcheng Zhang, Ph.D.

• ITIM-receptors and ligands in cancer and immunity

 Featured Publications

Secretogranin 2 binds LILRB4 resulting in immunosuppression.

Yang X, Huang R, Fang M, He Y, Xie J, Liu X, Zhang C, Lou Q, Deng M, Xiong W, Lewis C, Sadek Z, Gupta A, Chen L, Zhang X, Guo L, Xu L, Zhang N, An Z, Zhang CC, Nat Immunol 2025 Jul

LILRB3 supports acute myeloid leukemia development and regulates T cell anti-tumor immune responses through the TRAF2-cFLIP-NFkB signaling axis

Wu G, Xu Y, Schultz RD, Chen H, Xie J, Deng M, Liu X, Gui X, Jogn S, Lu Z, Arase H, Zhang N, An Z, Zhang CC Nature Cancer 2021

LILRB4 signaling in leukemia cells mediates T cell suppression and tumor infiltration

Deng M, Gui X, Kim J, Xie L, Chen W, Li Z, He L, Chen Y, Chen H, Luo W, Lu Z, Xie J, Churchill H, Xu Y, Zhou Z, Wu G, Yu C, John S, Hirayasu K, Nguyen N, Liu X, Huang F, Li L, Deng H, Tang H, Sadek AH, Zhang L, Huang T, Zou Y, Chen B, Zhu H, Arase H, Xia N, Jiang Y, Collins R, You MJ, Homsi J, Unni N, Lewis C, Chen GQ, Fu YX, Liao XC, An Z, Zheng J, Zhang N, Zhang CC Nature 2018

Fasting selectively blocks acute lymphoblastic leukemia development via leptin receptor upregulation

Lu Z*, Xie J*, Wu G, Shen J, Collins R, Chen W, Kang X, Luo M, Zou Y, Huang LJ, Amatruda JF, Slone T, Winick N, Scherer PE, Zhang CC Nature Medicine 2016 doi: 10.1038/nm.4252

The ITIM-containing receptor LAIR1 is essential for acute myeloid leukemia development

Kang X, Cui C, Lu Z, Dong B, Han X, Tyner JW, Coligan JE, Collins R, You JM, Zhang CC. Nature Cell Biology 2015 5 17 665-677

Inhibitory receptors bind Angptls and support blood stem cells and leukemia development

Zheng J*, Umikawa M*, Cui C*, Li J, Chen X, Zhang C, Huynh H, Kang X, Silvany R, Wan X, Ye J, Canto AP, Chen SH, Wang HY, Ward ES, Zhang CC. Nature 2012 485 656-660

Ex vivo expanded hematopoietic stem cells overcome the MHC barrier in allogeneic transplantation

Zheng J, Umikawa M, Zhang S, Huynh H, Silvany R, Chen BPC, Chen L, Zhang CC. Cell Stem Cell 2011 9 119-130

Metabolic Profiling Enriches for Hematopoietic Stem Cells

Simsek T, Kocabas F, Zheng J, DeBerardinis RJ, Olson EN, Schneider JW, Zhang CC*, Sadek HA* Cell Stem Cell 2010 7 380-390

Prion protein is expressed on long-term repopulating hematopoietic stem cells and is important for their self-renewal

Zhang CC, Steele AD, Lindquist S, Lodish HF Proc Natl Acad Sci U S A 2006 103 2184-2189

Angiopoietin-like proteins stimulate ex vivo expansion of hematopoietic stem cells

Zhang CC, Kaba M, Ge G, Xie K, Tong W, Hug C, Lodish HF Nature Medicine 2006 12 240-245

• Hortense L. and Morton H. Sanger Professorship in Oncology
  (2015)
• Leukemia & Lymphoma Society Scholar Award
  (2013)
• Royan International Research Award
  (2012)
• Gabrielle’s Angel Foundation for Cancer Research Fellow
  (2009)
• Basil O’Connor Scholar, March of Dimes Foundation
  (2008)
• American Society of Hematology Junior Faculty Scholar
  (2007)
• Howard Temin KO1 Award, National Cancer Institute
  (2006)
• Michael L. Rosenberg Scholar in Biomedical Research, UT Southwestern Medical Center
  (2006)

• American Society for Cell Biology
• American Society of Hematology
• International Society for Stem Cell Research