
Chengcheng Zhang, Ph.D.
Professor
Endowed Title Hortense L. and Morton H. Sanger Professorship in Oncology; Michael L. Rosenberg Scholar in Medical Research
School Medical School
Department Physiology
Graduate Programs Cancer Biology, Immunology
Education
- Undergraduate
- Univ of Science & Tech China , Molecular & Cell Biology
- Graduate School
- Chinese Academy of Sciences-Sh (1995), Biotechnology
- Graduate School
- Univ of Illinois @ Urbana-Cham (1999), Biochemistry
Research Interest
- ITIM-receptors and ligands in cancer and immunity
Publications
Featured Publications
- LILRB3 supports acute myeloid leukemia development and regulates T cell anti-tumor immune responses through the TRAF2-cFLIP-NFkB signaling axis
- Wu G, Xu Y, Schultz RD, Chen H, Xie J, Deng M, Liu X, Gui X, Jogn S, Lu Z, Arase H, Zhang N, An Z, Zhang CC Nature Cancer 2021
- LILRB4 signaling in leukemia cells mediates T cell suppression and tumor infiltration
- Deng M, Gui X, Kim J, Xie L, Chen W, Li Z, He L, Chen Y, Chen H, Luo W, Lu Z, Xie J, Churchill H, Xu Y, Zhou Z, Wu G, Yu C, John S, Hirayasu K, Nguyen N, Liu X, Huang F, Li L, Deng H, Tang H, Sadek AH, Zhang L, Huang T, Zou Y, Chen B, Zhu H, Arase H, Xia N, Jiang Y, Collins R, You MJ, Homsi J, Unni N, Lewis C, Chen GQ, Fu YX, Liao XC, An Z, Zheng J, Zhang N, Zhang CC Nature 2018
- Fasting selectively blocks acute lymphoblastic leukemia development via leptin receptor upregulation
- Lu Z*, Xie J*, Wu G, Shen J, Collins R, Chen W, Kang X, Luo M, Zou Y, Huang LJ, Amatruda JF, Slone T, Winick N, Scherer PE, Zhang CC Nature Medicine 2016 doi: 10.1038/nm.4252
- The ITIM-containing receptor LAIR1 is essential for acute myeloid leukemia development
- Kang X, Cui C, Lu Z, Dong B, Han X, Tyner JW, Coligan JE, Collins R, You JM, Zhang CC. Nature Cell Biology 2015 5 17 665-677
- Inhibitory receptors bind Angptls and support blood stem cells and leukemia development
- Zheng J*, Umikawa M*, Cui C*, Li J, Chen X, Zhang C, Huynh H, Kang X, Silvany R, Wan X, Ye J, Canto AP, Chen SH, Wang HY, Ward ES, Zhang CC. Nature 2012 485 656-660
- Ex vivo expanded hematopoietic stem cells overcome the MHC barrier in allogeneic transplantation
- Zheng J, Umikawa M, Zhang S, Huynh H, Silvany R, Chen BPC, Chen L, Zhang CC. Cell Stem Cell 2011 9 119-130
- Metabolic Profiling Enriches for Hematopoietic Stem Cells
- Simsek T, Kocabas F, Zheng J, DeBerardinis RJ, Olson EN, Schneider JW, Zhang CC*, Sadek HA* Cell Stem Cell 2010 7 380-390
- Prion protein is expressed on long-term repopulating hematopoietic stem cells and is important for their self-renewal
- Zhang CC, Steele AD, Lindquist S, Lodish HF Proc Natl Acad Sci U S A 2006 103 2184-2189
- Angiopoietin-like proteins stimulate ex vivo expansion of hematopoietic stem cells
- Zhang CC, Kaba M, Ge G, Xie K, Tong W, Hug C, Lodish HF Nature Medicine 2006 12 240-245
- Hypoxia induces heart regeneration in adult mice
- Nakada Y, Canseco DC, Thet S, Abdisalaam S, Asaithamby A, Santos CX, Shah A, Zhang H, Faber JE, Kinter MT, Szweda LI, Xing C, Deberardinis R, Oz O, Lu Z, Zhang CC, Kimura W, Sadek HA Nature 2016 doi: 10.1038/nature20173
Honors & Awards
- Hortense L. and Morton H. Sanger Professorship in Oncology
(2015) - Leukemia & Lymphoma Society Scholar Award
(2013) - Royan International Research Award
(2012) - Gabrielle’s Angel Foundation for Cancer Research Fellow
(2009) - Basil O’Connor Scholar, March of Dimes Foundation
(2008) - American Society of Hematology Junior Faculty Scholar
(2007) - Howard Temin KO1 Award, National Cancer Institute
(2006) - Michael L. Rosenberg Scholar in Biomedical Research, UT Southwestern Medical Center
(2006)
Professional Associations/Affiliations
- American Society for Cell Biology
- American Society of Hematology
- International Society for Stem Cell Research