
Shuzhen Liu, Ph.D.
Instructor
Department Internal Medicine
Biography
Dr. Liu received her Ph.D. from University of Rostock, Germany. She completed postdoc training and became a faculty at UT Southwestern.
Dr. Liu is interested in molecular mechanism of TNF induced necroptosis and pathogen mediated inflammation, cancer and autoimmune diseases.
Education
- Undergraduate
- (2016), Microbiology
- Graduate School
- (2016), Molecular Biology
- Graduate School
- (2016), None
- Graduate School
- (2016), Biochemistry
Research Interest
- Cancer
- Inflammation
- Necroptosis
Publications
Featured Publications
- Necroptosis-blocking compound NBC1 targets heat shock protein 70 to inhibit MLKL polymerization and necroptosis.
- Johnston AN, Ma Y, Liu H, Liu S, Hanna-Addams S, Chen S, Chen C, Wang Z, Proc. Natl. Acad. Sci. U.S.A. 2020 Mar 117 12 6521-6530
- CK1a, CK1d, and CK1e are necrosome components which phosphorylate serine 227 of human RIPK3 to activate necroptosis.
- Hanna-Addams S, Liu S, Liu H, Chen S, Wang Z, Proc. Natl. Acad. Sci. U.S.A. 2020 Jan 117 4 1962-1970
- MLKL forms disulfide bond-dependent amyloid-like polymers to induce necroptosis.
- Liu S, Liu H, Johnston A, Hanna-Addams S, Reynoso E, Xiang Y, Wang Z Proc. Natl. Acad. Sci. U.S.A. 2017 Aug
- The erythropoietin receptor is a downstream effector of Klotho-induced cytoprotection.
- Hu MC, Shi M, Cho HJ, Zhang J, Pavlenco A, Liu S, Sidhu S, Huang LJ, Moe OW Kidney Int. 2013 May
- Lingual antimicrobial peptide and IL-8 expression are oppositely regulated by the antagonistic effects of NF-?B p65 and C/EBP? in mammary epithelial cells.
- Liu S, Shi X, Bauer I, Günther J, Seyfert HM, Mol. Immunol. 2011 Mar 48 6-7 895-908
- Salmonid Tollip and MyD88 factors can functionally replace their mammalian orthologues in TLR-mediated trout SAA promoter activation.
- Rebl A, Rebl H, Liu S, Goldammer T, Seyfert HM, Dev. Comp. Immunol. 2011 Jan 35 1 81-7
- C/EBP-beta drives expression of the nutritionally regulated promoter IA of the acetyl-CoA carboxylase-alpha gene in cattle.
- Shi X, Liu S, Metges CC, Seyfert HM, Biochim. Biophys. Acta 2010 Aug 1799 8 561-7
- Stimulated expression of TNF-alpha and IL-8, but not of lingual antimicrobial peptide reflects the concentration of pathogens contacting bovine mammary epithelial cells.
- Günther J, Liu S, Esch K, Schuberth HJ, Seyfert HM, Vet. Immunol. Immunopathol. 2010 May 135 1-2 152-157
- Molecular cloning and characterization of a laccase gene from the basidiomycete Fome lignosus and expression in Pichia pastoris.
- Liu W, Chao Y, Liu S, Bao H, Qian S, Appl. Microbiol. Biotechnol. 2003 Dec 63 2 174-81