Biography

Dr. Marianna Dakanali is an Instructor in the Department of Radiology and the Regulatory Affairs Officer for the Cyclotron and Radiochemistry Program.

Dr. Dakanali obtained her B.S. and M.Sc. in Chemistry from the University of Crete, Greece and her Ph.D. in total synthesis of bioactive natural products from the Agricultural University of Athens, Greece and the National Center of Scientific Research “Democritos”. After three years of postdoctoral training with Professor E. A. Theodorakis at the University of California San Diego in total synthesis of bioactive natural products, as well as the design and synthesis of fluorescent tracers, Dr. Dakanali joined Dr. Sun’s group at the University of Texas Southwestern in 2012 and she was involved in the design and synthesis of Positron Emission Tomography (PET) tracers.

Dr. Dakanali was appointed as faculty at UT Southwestern in early 2015. Her primary role involves the oversight and coordination of the Cyclotron & Radiochemistry Program’s regulatory compliance, and is responsible for the preparation, assembly, and FDA and Radioactive Drug Research Committee (RDRC) filings. She maintains the regulatory records and facilitates the clinical research of radiotracers.

Dr. Dakanali’s research interests involve the design and synthesis of novel radiotracers for the diagnosis of liver and lung fibrosis and cancer.

Research Interest

  • Design and synthesis of novel radiotracers for the diagnosis of liver and lung fibrosis and cancer
  • FDA regulations of PET drugs
  • Preparation of IND, eIND or RDRC applications for use of PET drugs

Publications

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Enantiopure bifunctional chelators for copper radiopharmaceuticals--does chirality matter in radiotracer design?
Singh AN, Dakanali M, Hao G, Ramezani S, Kumar A, Sun X Eur J Med Chem 2014 Jun 80 308-15
An unusual Michael-induced skeletal rearrangement of a bicyclo[3.3.1]nonane framework of phloroglucinols to a novel bioactive bicyclo[3.3.0]octane.
Vidali VP, Mitsopoulou KP, Dakanali M, Demadis KD, Odysseos AD, Christou YA, Couladouros EA Org. Lett. 2013 Nov 15 21 5404-7
A-ring oxygenation modulates the chemistry and bioactivity of caged Garcinia xanthones.
Elbel KM, Guizzunti G, Theodoraki MA, Xu J, Batova A, Dakanali M, Theodorakis EA Org. Biomol. Chem. 2013 May 11 20 3341-8
Aminonaphthalene 2-cyanoacrylate (ANCA) probes fluorescently discriminate between amyloid-ß and prion plaques in brain.
Cao K, Farahi M, Dakanali M, Chang WM, Sigurdson CJ, Theodorakis EA, Yang J J. Am. Chem. Soc. 2012 Oct 134 42 17338-41
Self-calibrating viscosity probes: design and subcellular localization.
Dakanali M, Do TH, Horn A, Chongchivivat A, Jarusreni T, Lichlyter D, Guizzunti G, Haidekker MA, Theodorakis EA Bioorg. Med. Chem. 2012 Jul 20 14 4443-50
Subcellular localization and activity of gambogic acid.
Guizzunti G, Batova A, Chantarasriwong O, Dakanali M, Theodorakis EA Chembiochem 2012 May 13 8 1191-8
Intrinsic and extrinsic temperature-dependency of viscosity-sensitive fluorescent molecular rotors.
Howell S, Dakanali M, Theodorakis EA, Haidekker MA J Fluoresc 2012 Jan 22 1 457-65
Intramolecular Cyclization Strategies Toward the Synthesis of Zoanthamine Alkaloids.
Fischer D, Nguyen TX, Trzoss L, Dakanali M, Theodorakis EA Tetrahedron Lett. 2011 Sep 52 38 4920-4923
Enantioselective synthesis of the ABC ring motif of norzoanthamine based on asymmetric Robinson annulation reactions.
Nguyen TX, Dakanali M, Trzoss L, Theodorakis EA Org. Lett. 2011 Jul 13 13 3308-11
Detection of liposome membrane viscosity perturbations with ratiometric molecular rotors.
Nipper ME, Dakanali M, Theodorakis E, Haidekker MA Biochimie 2011 Jun 93 6 988-94

Books

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