Dr. Grundy's major research area is in cholesterol and lipoprotein metabolism. He has published over 400 original papers, and numerous solicited articles and chapters. Notable research accomplishments include the development of methods for measuring cholesterol balance and biliary lipid secretion in humans, identifying the metabolic causes of cholesterol gallstones, defining effects of saturated and unsaturated fats, especially monounsaturated fatty acids, on cholesterol and lipoprotein metabolism, uncovering genetic defects underlying hypercholesterolemia and other forms of dyslipidemia, identifying metabolic defects in hypercholesterolemia, hypertriglyceridemia, hypoalphalipoproteinemia, and defining mechanisms of action of several lipid-lowering drugs, notably fibrates and HMG CoA reductase inhibitors (statins).


Medical School
Baylor College of Medicine (1960)
Graduate School
Rockefeller University (1968)

Clinical Interest

  • Internal Medicine
  • Research Interest

    • Cholesterol Metabolism
    • Dietary Fats
    • Drugs Affecting Lipoprotein Metabolism
    • Human Genetics
    • Metabolic Syndrome

    Honors & Awards

    • American Heart Association
      Gold Heart Award (2010)
    • American Heart Association
      Discovery Award (2000)
    • American Society of Clinical Nutrition
      The E.V. McCollum Award (1998)
    • Baylor College of Medicine
      Distinguished Alumnus (1998)
    • American Heart Association
      Distinguished Achievement Award (1997)
    • University of Finland
      Honorary Doctorate (1995)

    Professional Associations/Affiliations

    • American Association of Physicians
    • American Institute of Nutrition
    • American Society for Clinical Investigation
    • National Academies Institute of Medicine