Featured Publications
Foxo1 is required in mouse spermatogonial stem cells for their maintenance and the initiation of spermatogenesis.
Goertz MJ, Wu Z, Gallardo TD, Hamra FK, Castrillon DH J. Clin. Invest. 2011 Sep 121 9 3456-66
Lkb1 inactivation is sufficient to drive endometrial cancers that are aggressive yet highly responsive to mTOR inhibitor monotherapy.
Contreras CM, Akbay EA, Gallardo TD, Haynie JM, Sharma S, Tagao O, Bardeesy N, Takahashi M, Settleman J, Wong KK, Castrillon DH Dis Model Mech 2010 Mar-Apr 3 3-4 181-93
Somatic LKB1 mutations promote cervical cancer progression.
Wingo SN, Gallardo TD, Akbay EA, Liang MC, Contreras CM, Boren T, Shimamura T, Miller DS, Sharpless NE, Bardeesy N, Kwiatkowski DJ, Schorge JO, Wong KK, Castrillon DH PLoS ONE 2009 4 4 e5137
Foxo3 is a PI3K-dependent molecular switch controlling the initiation of oocyte growth.
John GB, Gallardo TD, Shirley LJ, Castrillon DH Dev. Biol. 2008 Sep 321 1 197-204
FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis.
Paik JH, Kollipara R, Chu G, Ji H, Xiao Y, Ding Z, Miao L, Tothova Z, Horner JW, Carrasco DR, Jiang S, Gilliland DG, Chin L, Wong WH, Castrillon DH, DePinho RA Cell 2007 Jan 128 2 309-23
Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a.
Castrillon DH, Miao L, Kollipara R, Horner JW, DePinho RA Science 2003 Jul 301 5630 215-8
