David Wang, M.D., Ph.D.

Assistant Professor

Department: Internal Medicine

Biography

Dr. Wang received his B.A. degree from Asbury College and his M.D. degree from Vanderbilt University.  During medical school, he spent a year at the National Cancer Institute as an HHMI-NIH Research Scholar working in the laboratory of Dr. Robert Lechleider and Dr. Anita Roberts where he investigated TGF-beta and BMP signal transduction.  Dr. Wang then completed residency training on the Osler Medical Service of the Johns Hopkins Hospital and fellowship training in medical oncology at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins.  At the conclusion of his postdoctoral training in the laboratory of Dr. D. Neil Watkins, he received his Ph.D. degree in Cellular and Molecular Medicine from the Johns Hopkins University.  His dissertation research examined the role of Hedgehog signaling in Barrett’s esophagus and esophageal adenocarcinoma.  Dr. Wang’s laboratory is focused on understanding the role of aberrant developmental pathway signaling in esophageal cancer and precursor lesions.  In his clinic, Dr. Wang sees patients with esophageal cancer, gastric cancer, and other gastrointestinal malignancies. 

Education

Medical School Vanderbilt University (1999), Mohs Surgery
Internship Johns Hopkins Hospital (2000), Internal Medicine
Residency Johns Hopkins Hospital (2002), Internal Medicine
Fellowship Johns Hopkins Hospital (2004), Medical Oncology
Fellowship Johns Hopkins Hospital (2009), Oncology
Graduate School Johns Hopkins School of Medicine (2009)

Research Interests

  • Barrett's esophagus
  • Esophageal cancer
  • Gastric cancer
  • Hedgehog signaling
  • Molecularly targeted therapy

Publications

Featured Publications Legend

Featured Publications

Biology of Barrett’s esophagus and esophageal adenocarcinoma.

DH Wang, RF Souza Gastrointestinal Endoscopy Clinics of North America January 2011 21 (1) 25-38

Cancer-related inflammation and Barrett’s carcinogenesis: Interleukin-6 and STAT3 mediate apoptotic resistance in transformed Barrett’s cells.

HY Zhang, Q Zhang, X Zhang, C Yu, X Huo, E Cheng, DH Wang, SJ Spechler, RF Souza American Journal of Physiology. Gastrointestinal and Liver Physiology. 2011 (In press)

Epigenetic inactivation of the canonical Wnt antagonist Sry-box containing gene 17 in colorectal cancer.

W Zhang, SC Glockner, M Guo, EO Machida, DH Wang, H Easwaran, L Van Neste, JG Herman, KE Schuebel, DN Watkins, N Ahuja, SB Baylin Cancer Research April 2008 68 (8) 2764-72

The Smad4 activation domain (SAD) is a proline-rich, p300-dependent transcriptional activation domain.

MP de Caestecker, T Yahata, D Wang, WT Parks, S Huang, CS Hill, T Shioda, AB Roberts, RJ Lechleider The Journal of Biological Chemistry January 2000 275 (3) 2115-22

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Honors/Awards

  • NCI
    National Research Service Award (2006)
  • American Society of Clinical Oncology
    Young Investigator Award (2005)
  • The Endocrine Society
    Medical Student Achievement Award (1999)
  • Howard Hughes Medical Institute
    Continued Fellowship for Medical Studies (1998)

Professional Associations/Affiliations

  • American Association for Cancer Research
  • American Gastroenterological Association
  • American Society of Clinical Oncology