Medical School
University of Tennessee Health Science Center (1999)
Washington University in St. Louis School of Medicine (2002), Internal Medicine
Washington University School of Medicine (2006), Pulmonary Diseases & Critical Care Medicine
Graduate School
Washington University School of Medicine (2009)

Specialty Areas

Clinical Interest

  • Hereditary Hemorrhagic Telangiectasia (HHT)
  • Research Interest

    • Airway inflammation in COPD and asthma
    • Alternative macrophage activation
    • Immune mechanisms of acute and chronic lung injury
    • Role of infection in the development of chronic inflammation lung disease


    Featured Publications LegendFeatured Publications

    Macrophage chitinase 1 stratifies chronic obstructive lung disease
    Agapov E, Battaile JT, Tidwell R, Hachem R, Patterson GA, Pierce RA, Atkinson JA, Holtzman MH American Journal Respir Cell Mol Biol. June 2009
    Elastin expression in very severe human COPD
    Deslee G, Woods JC, Moore CM, Liu L, Conradi SH, Milne M, Gierada DS, Pierce J, Patterson A, Lewit RA, Battaile JT, Holtzman MJ, Hogg JC, Pierce RA Eur Respir J. April 2009
    Oxidative damage to nucleic acids in severe emphysema
    Deslee G, Woods JC, Moore C, Conradi SH, Gierada DS, Atkinson JJ, Battaile JT, Liu L, Patterson A, Adair-Kirk TL, Holtzman MJ, Pierce RA Chest April 2009 135(4): 965-74
    Immune pathways for translating viral infection into chronic airways disease
    Holtzman MJ, Byers DE, Benoit LA, Battaile JT, You Y, Agapov E, Park C, Grayson MH, Kim EY, Patel AC Adv Immunol 2009 102:245-76
    Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease
    Kim EY, Battaile JT, Patel AC, Agapov E, Grayson MH, Benoit LA, Byers DE, Alevy Y, Tucker J, Swanson S, Tidwell R, Tyner JW, Morton JD, Castro M, Polineni D, Patterson GA, Schwendener RA, Allard JD, Peltz G, Holtzman MJ Nat Med. June 2008 14(6): 633-40

    Honors & Awards

    • Multidisciplinary Clinical Research Career Development Award
    • Knowlton Award for Clinical Excellence
    • Clinicopathologic Conference
      Elected by fellow residents as discussant for year-end conference (2002)

    Professional Associations/Affiliations

    • American College of Chest Physicians
    • American Medical Association
    • American Thoracic Society