Yucel Akgul, M.D., Ph.D. Assistant Professor School Medical School Department Plastic Surgery Biography Yucel Akgul received an MD from the Cumhuriyet University School of Medicine in 1998 and a PhD in Physiology from the West Virginia University in 2007. He was a postdoctoral fellow from 2008-2014 with Dr. Mala Mahendroo at the UT Southwestern Medical Center. He joined the faculty at UT Southwestern in 2016. The goal of his lab is to understand molecular mechanism of extracellular matrix (ECM) remodeling in wound healing to develop therapies and diagnostic tools against delayed and abnormal wound healing. Delayed and abnormal wound healing is a serious health problem for millions of patients suffering each year from non- healing skin ulcers, or from excessive scarring after trauma. Education Medical School (1998), Medicine Graduate School West Virginia University (2007), Physiology Research Interest Extracellular matrix (ECM) remodeling in wound healing Publications Featured Publications Hyaluronan in cervical epithelia protects against infection-mediated preterm birth. Akgul Y, Word RA, Ensign LM, Yamaguchi Y, Lydon J, Hanes J, Mahendroo M J. Clin. Invest. 2014 Dec 124 12 5481-9 The molecular mechanisms of cervical ripening differ between term and preterm birth. Holt R, Timmons BC, Akgul Y, Akins ML, Mahendroo M Endocrinology 2011 Mar 152 3 1036-46 Fetal fibronectin signaling induces matrix metalloproteases and cyclooxygenase-2 (COX-2) in amnion cells and preterm birth in mice. Mogami H, Kishore AH, Shi H, Keller PW, Akgul Y, Word RA J. Biol. Chem. 2013 Jan 288 3 1953-66 Dynamic changes in cervical glycosaminoglycan composition during normal pregnancy and preterm birth. Akgul Y, Holt R, Mummert M, Word A, Mahendroo M Endocrinology 2012 Jul 153 7 3493-503 Changes of large molecular weight hyaluronan and versican in the mouse pubic symphysis through pregnancy. Rosa RG, Akgul Y, Joazeiro PP, Mahendroo M Biol. Reprod. 2012 Feb 86 2 44 Antioxidant protects against increases in low molecular weight hyaluronan and inflammation in asphyxiated newborn pigs resuscitated with 100% oxygen. Østerholt HC, Dannevig I, Wyckoff MH, Liao J, Akgul Y, Ramgopal M, Mija DS, Cheong N, Longoria C, Mahendroo M, Nakstad B, Saugstad OD, Savani RC PLoS ONE 2012 7 6 e38839 The methoxychlor metabolite, HPTE, inhibits rat luteal cell progesterone production. Akgul Y, Derk RC, Meighan T, Rao KM, Murono EP Reprod. Toxicol. 2011 Jul 32 1 77-84 Ex vivo assessment of mouse cervical remodeling through pregnancy via 23Na MRS. Xu X, Akgul Y, Mahendroo M, Jerschow A NMR Biomed 2010 Oct 23 8 907-12 The methoxychlor metabolite, HPTE, directly inhibits the catalytic activity of cholesterol side-chain cleavage (P450scc) in cultured rat ovarian cells. Akgul Y, Derk RC, Meighan T, Rao KM, Murono EP Reprod. Toxicol. 2008 Jan 25 1 67-75 In vivo exposure of young adult male rats to methoxychlor reduces serum testosterone levels and ex vivo Leydig cell testosterone formation and cholesterol side-chain cleavage activity. Murono EP, Derk RC, Akgul Y Reprod. Toxicol. 2006 Feb 21 2 148-53 Results 1-10 of 10 1 Books Featured Books Cervical Changes Accompanying Birth. In The Guide to Investigation of Mouse Pregnancy Yucel Akgul, Mala Mahendroo (2014). Academic Press, Elsevier Assessment of Changes in the Peripartum Cervix. In The Guide to Investigation of Mouse Pregnancy Yucel Akgul, Mala Mahendroo (2014). Academic Press, Elsevier
