Download Curriculum Vitae

Ralph DeBerardinis earned a B.S. in biology from St. Joseph’s University and M.D. and Ph.D. degrees from the University of Pennsylvania. Dr. DeBerardinis was the first trainee in the combined residency program in pediatrics and medical genetics at The Children’s Hospital of Philadelphia (CHOP) and received several awards for teaching and clinical care. He ultimately achieved board certification in pediatrics, medical genetics and clinical biochemical genetics.

Dr. DeBerardinis performed postdoctoral research in Craig Thompson’s laboratory in the Penn Cancer Center from 2004 to 2007. He joined the faculty of the University of Texas Southwestern Medical Center in 2008 and joined the Children’s Medical Center Research Institute at UT Southwestern (CRI) shortly after its founding in 2012. Dr. DeBerardinis serves as chief of Pediatric Genetics and Metabolism at UT Southwestern and director of the Genetic and Metabolic Disease Program in the CRI. Dr. DeBerardinis became a Howard Hughes Medical Institute (HHMI) Investigator in 2018.

The DeBerardinis laboratory is interested in the role of altered metabolic states in human diseases, particularly pediatric inborn errors of metabolism and cancer. This research is tightly integrated with clinical activities in medical genetics, oncology and radiology, providing seamless opportunities to examine the relevance of findings in patients.

DeBerardinis Laboratory


Medical School
University of Pennsylvania School of Medicine (2000)
Children's Hospital of Philadelphia (2005), Pediatrics & Medical Genetics

Research Interest

  • Cancer
  • Genetic disorders in children
  • Inborn errors of metabolism
  • Metabolism


Featured Publications LegendFeatured Publications

Isotope Tracing of Human Clear Cell Renal Cell Carcinomas Demonstrates Suppressed Glucose Oxidation In Vivo.
Courtney KD, Bezwada D, Mashimo T, Pichumani K, Vemireddy V, Funk AM, Wimberly J, McNeil SS, Kapur P, Lotan Y, Margulis V, Cadeddu JA, Pedrosa I, DeBerardinis RJ, Malloy CR, Bachoo RM, Maher EA Cell Metab. 2018 Aug
Inosine Monophosphate Dehydrogenase Dependence in a Subset of Small Cell Lung Cancers.
Huang F, Ni M, Chalishazar MD, Huffman KE, Kim J, Cai L, Shi X, Cai F, Zacharias LG, Ireland AS, Li K, Gu W, Kaushik AK, Liu X, Gazdar AF, Oliver TG, Minna JD, Hu Z, DeBerardinis RJ Cell Metab. 2018 Jun
Loss of a Negative Regulator of mTORC1 Induces Aerobic Glycolysis and Altered Fiber Composition in Skeletal Muscle.
Dutchak PA, Estill-Terpack SJ, Plec AA, Zhao X, Yang C, Chen J, Ko B, Deberardinis RJ, Yu Y, Tu BP Cell Rep 2018 May 23 7 1907-1914

Honors & Awards

  • Best Pediatric Specialists/Doctors in Dallas
    D Magazine (2016) (2018)
  • Howard Hughes Medical Institute Investigator
  • Howard Hughes Medical Institute Faculty Scholar
  • NCI Outstanding Investigator
  • Robert L. Moody, Sr. Faculty Scholar
  • Damon Runyon Cancer Research Foundation Clinical Investigator Award
  • President’s Research Council Distinguished Young Researcher Award
  • Soc. for Inherited Metabolic Disorders Neil Buist Award
  • Sowell Family Scholar in Medical Research
  • William K. Bowes, Jr. Award in Medical Genetics
  • CHOP Pediatric Scholars Program & Faculty Honor Roll
  • American Society for Clinical Investigation

Professional Associations/Affiliations

  • Investigator, Howard Hughes Medical Institute (2018)
  • American Society for Clinical Investigation (2013)
  • American Academy of Pediatrics
  • American Association for Cancer Research
  • American Society of Human Genetics
  • Society for Inherited Metabolic Disorders
  • Society for Pediatrics Research