Download Curriculum Vitae

Ralph DeBerardinis earned a B.S. in biology from St. Joseph’s University and M.D. and Ph.D. degrees from the University of Pennsylvania. Dr. DeBerardinis was the first trainee in the combined residency program in pediatrics and medical genetics at The Children’s Hospital of Philadelphia (CHOP) and received several awards for teaching and clinical care. He ultimately achieved board certification in pediatrics, medical genetics and clinical biochemical genetics.

Dr. DeBerardinis performed postdoctoral research in Craig Thompson’s laboratory in the Penn Cancer Center from 2004 to 2007. He joined the faculty of the University of Texas Southwestern Medical Center in 2008 and joined the Children’s Medical Center Research Institute at UT Southwestern (CRI) shortly after its founding in 2012. Dr. DeBerardinis serves as chief of Pediatric Genetics and Metabolism at UT Southwestern and director of the Genetic and Metabolic Disease Program in the CRI. Dr. DeBerardinis became a Howard Hughes Medical Institute (HHMI) Investigator in 2018.

The DeBerardinis laboratory is interested in the role of altered metabolic states in human diseases, particularly pediatric inborn errors of metabolism and cancer. This research is tightly integrated with clinical activities in medical genetics, oncology and radiology, providing seamless opportunities to examine the relevance of findings in patients.

DeBerardinis Laboratory


Medical School
University of Pennsylvania School of Medicine (2000)
Children's Hospital of Philadelphia (2005), Pediatrics & Medical Genetics

Research Interest

  • Cancer
  • Genetic disorders in children
  • Inborn errors of metabolism
  • Metabolism


Featured Publications LegendFeatured Publications

Genomic regression analysis of coordinated expression.
Cai L, Li Q, Du Y, Yun J, Xie Y, DeBerardinis RJ, Xiao G Nat Commun 2017 Dec 8 1 2187
The abundance of metabolites related to protein methylation correlates with the metastatic capacity of human melanoma xenografts.
Shi X, Tasdogan A, Huang F, Hu Z, Morrison SJ, DeBerardinis RJ Sci Adv 2017 Nov 3 11 eaao5268
Metabolic Strategies of Melanoma Cells: Mechanisms, Interactions with the Tumor Microenvironment, and Therapeutic Implications.
Fischer GM, Vashisht Gopal YN, McQuade JL, Peng W, DeBerardinis RJ, Davies MA Pigment Cell Melanoma Res 2017 Oct

Honors & Awards

  • Howard Hughes Medical Institute Faculty Scholar
  • NCI Outstanding Investigator
  • Robert L. Moody, Sr. Faculty Scholar
  • Damon Runyon Cancer Research Foundation Clinical Investigator Award
  • President’s Research Council Distinguished Young Researcher Award
  • Soc. for Inherited Metabolic Disorders Neil Buist Award
  • Sowell Family Scholar in Medical Research
  • William K. Bowes, Jr. Award in Medical Genetics
  • CHOP Pediatric Scholars Program & Faculty Honor Roll
  • American Society for Clinical Investigation

Professional Associations/Affiliations

  • Investigator, Howard Hughes Medical Institute (2018)
  • American Society for Clinical Investigation (2013)
  • American Academy of Pediatrics
  • American Association for Cancer Research
  • American Society of Human Genetics
  • Society for Inherited Metabolic Disorders
  • Society for Pediatrics Research