Dr. Zhang joined UT Southwestern as an assistant professor in September, 2007. He previously was a postdoctoral fellow at the University of Texas M.D. Anderson Cancer Center.

Dr. Zhang’s research interest in statistical methodology lies in two main areas: Bayesian hierarchical modeling and clinical trial design. He has published multiple papers on the application of Bayesian hierarchical models to disease mapping, joint modeling of longitudinal and survival outcomes, item-response theory for grant review, functional enrichment analysis to detect important pathways, and multi-level modeling to detect factors that impact cancer screening, etc. Another area of his research interest is design methodology for clinical trials to account for various pragmatic issues such as correlated outcomes (clustered and longitudinal), missing data, small sample sizes, historical control, random variability in cluster size, and cost constraints, etc. He has published multiple high quality papers in this area and in 2015 he co-authored a book titled “Sample Size Calculations on Clustered and Longitudinal Outcomes in Clinical Research” (Chapman & Hall, New York). Dr. Zhang has been successful in securing extramural grants as the PI to support his independent research program: an NIH R03 grant to conduct secondary data analysis on VA HIV registry in 2012; an NSF grant to build risk prediction model based on electronic health record data in 2013; and a PCORI methodology development grant to address pragmatic design issues in stepped-wedge cluster randomized trials in 2017.


Graduate School
Xiamen University - China , Econometrics
Graduate School
University of Missouri-Columbi (2005), Statistics

Research Interest

  • Bayesian statistical methods
  • Bioinformatics
  • Clinical trial design
  • Missing data methods
  • Multi-level models


Featured Publications LegendFeatured Publications

Chronologic comparison of root dentin moisture in extracted human teeth stored in formalin, sodium azide, and distilled water.
Komabayashi T, Ahn C, Zhang S, Zhu Q, Spångberg LS Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009 Jul 108 1 e50-4
Root dentin body moisture changes caused by ascorbic acid.
Komabayashi T, Ahn C, Zhang S, Zhu Q, Spångberg LS J Dent 2009 Jun 37 6 475-9
Immunologic, clinical, and radiologic status 14 months after cessation of natalizumab therapy.
Stüve O, Cravens PD, Frohman EM, Phillips JT, Remington GM, von Geldern G, Cepok S, Singh MP, Tervaert JW, De Baets M, MacManus D, Miller DH, Radü EW, Cameron EM, Monson NL, Zhang S, Kim R, Hemmer B, Racke MK Neurology 2009 Feb 72 5 396-401
A close examination of double filtering with fold change and T test in microarray analysis.
Zhang S, Cao J BMC Bioinformatics 2009 10 402
A Bayesian Discovery Procedure
M. Guindani, P. Muller, S. Zhang Journal of the Royal Statistical Society, Series B (statistical methodology) 2009
Bayesian optimal discovery procedure for simultaneous significance testing.
Cao J, Xie XJ, Zhang S, Whitehurst A, White MA BMC Bioinformatics 2009 10 5
A Spatially-adjusted Bayesian Additive Regression Tree Model to Merge Two Datasets
S. Zhang, YCT. Shih and P. Muller Bayesian Analysis 2007 2(3) 611-634
A Bayesian semi-parametric model for colorectal cancer incidences.
Zhang S, Sun D, He CZ, Schootman M Stat Med 2006 Jan 25 2 285-309


Featured Books Legend Featured Books

Honors & Awards

  • Early Career Researcher and Postgraduate travel awards
    International Society for Bayesian Analysis (2008)
  • Graduate Professional Council Travel Scholarship
    University of Missouri-Columbia (2004)
  • Outstanding Performance in Doctoral Exams
    Department of Statistics, University of Missouri-Columbia (2003)
  • Excellent Student Award
    Xiamen University, China (1999)
  • Third Prize
    College Student Science and Technology Thesis Competition, Fujian, China (1998)

Professional Associations/Affiliations

  • Eastern North American Region (ENAR) of the International Biometric Society (IBS)
  • Institute of Mathematical Statistics
  • The American Statistical Association