Biography

Dr. Zhang joined UT Southwestern as an assistant professor in September, 2007. He previously was a postdoctoral fellow at the University of Texas M.D. Anderson Cancer Center.

Dr. Zhang’s research interest in statistical methodology lies in two main areas: Bayesian hierarchical modeling and clinical trial design. He has published multiple papers on the application of Bayesian hierarchical models to disease mapping, joint modeling of longitudinal and survival outcomes, item-response theory for grant review, functional enrichment analysis to detect important pathways, and multi-level modeling to detect factors that impact cancer screening, etc. Another area of his research interest is design methodology for clinical trials to account for various pragmatic issues such as correlated outcomes (clustered and longitudinal), missing data, small sample sizes, historical control, random variability in cluster size, and cost constraints, etc. He has published multiple high quality papers in this area and in 2015 he co-authored a book titled “Sample Size Calculations on Clustered and Longitudinal Outcomes in Clinical Research” (Chapman & Hall, New York). Dr. Zhang has been successful in securing extramural grants as the PI to support his independent research program: an NIH R03 grant to conduct secondary data analysis on VA HIV registry in 2012; an NSF grant to build risk prediction model based on electronic health record data in 2013; and a PCORI methodology development grant to address pragmatic design issues in stepped-wedge cluster randomized trials in 2017.

Education

Graduate School
Xiamen University - China , Econometrics
Graduate School
University of Missouri-Columbi (2005), Statistics

Research Interest

  • Bayesian statistical methods
  • Bioinformatics
  • Clinical trial design
  • Missing data methods
  • Multi-level models

Publications

Featured Publications LegendFeatured Publications

Electronic medical record-based multicondition models to predict the risk of 30 day readmission or death among adult medicine patients: validation and comparison to existing models.
Amarasingham R, Velasco F, Xie B, Clark C, Ma Y, Zhang S, Bhat D, Lucena B, Huesch M, Halm EA BMC Med Inform Decis Mak 2015 15 39
In vivo detection of citrate in brain tumors by (1) H magnetic resonance spectroscopy at 3T.
Choi C, Ganji SK, Madan A, Hulsey KM, An Z, Zhang S, Pinho MC, DeBerardinis RJ, Bachoo RM, Maher EA Magn Reson Med 2014 Aug 72 2 316-23
Molecular markers of carcinogenesis for risk stratification of individuals with colorectal polyps: a case-control study.
Gupta S, Sun H, Yi S, Storm J, Xiao G, Balasubramanian BA, Zhang S, Ashfaq R, Rockey D Cancer Prev Res (Phila) 2014 Aug
Applicability of apparent diffusion coefficient ratios in preoperative diagnosis of common pediatric cerebellar tumors across two institutions.
Koral K, Alford R, Choudhury N, Mossa-Basha M, Gargan L, Gimi B, Gao A, Zhang S, Bowers DC, Koral KM, Izbudak I Neuroradiology 2014 Jun
CD4 counts and mortality in virologically suppressed US veterans.
Drechsler H, Zhang S, Holodniy M, Bedimo R J Int Assoc Provid AIDS Care 2014 Mar-Apr 13 2 120-6
A GEE Approach to Determine Sample Size for Pre- and Post-Intervention Experiments with Dropout.
Zhang S, Cao J, Ahn C Comput Stat Data Anal 2014 Jan 69
The RADAR Study: Week 48 Safety and Efficacy of RAltegravir Combined with Boosted DARunavir Compared to Tenofovir/Emtricitabine Combined with Boosted Darunavir in Antiretroviral-Naive Patients. Impact on Bone Health.
Bedimo RJ, Drechsler H, Jain M, Cutrell J, Zhang S, Li X, Farukhi I, Castanon R, Tebas P, Maalouf NM PLoS ONE 2014 9 8 e106221
The LKB1 tumor suppressor as a biomarker in mouse and human tissues.
Nakada Y, Stewart TG, Peña CG, Zhang S, Zhao N, Bardeesy N, Sharpless NE, Wong KK, Hayes DN, Castrillon DH PLoS ONE 2013 8 9 e73449
Long-term benefit of hepatitis C therapy in a safety net hospital system: a cross-sectional study with median 5-year follow-up.
Singal AG, Dharia TD, Malet PF, Alqahtani S, Zhang S, Cuthbert JA BMJ Open 2013 3 9 e003231
Seizure Localization Using Broadband EEG: Comparison of Conventional Frequency Activity, High-Frequency Oscillations, and Infraslow Activity.
Modur PN, Vitaz TW, Zhang S J Clin Neurophysiol 2012 Aug 29 4 309-19

Books

Featured Books Legend Featured Books

Honors & Awards

  • Early Career Researcher and Postgraduate travel awards
    International Society for Bayesian Analysis (2008)
  • Graduate Professional Council Travel Scholarship
    University of Missouri-Columbia (2004)
  • Outstanding Performance in Doctoral Exams
    Department of Statistics, University of Missouri-Columbia (2003)
  • Excellent Student Award
    Xiamen University, China (1999)
  • Third Prize
    College Student Science and Technology Thesis Competition, Fujian, China (1998)

Professional Associations/Affiliations

  • Eastern North American Region (ENAR) of the International Biometric Society (IBS)
  • Institute of Mathematical Statistics
  • The American Statistical Association