Dr. Zhang joined UT Southwestern as an assistant professor in September, 2007. He previously was a postdoctoral fellow at the University of Texas M.D. Anderson Cancer Center.
Dr. Zhang’s research interest in statistical methodology lies in two main areas: Bayesian hierarchical modeling and clinical trial design. He has published multiple papers on the application of Bayesian hierarchical models to disease mapping, joint modeling of longitudinal and survival outcomes, item-response theory for grant review, functional enrichment analysis to detect important pathways, and multi-level modeling to detect factors that impact cancer screening, etc. Another area of his research interest is design methodology for clinical trials to account for various pragmatic issues such as correlated outcomes (clustered and longitudinal), missing data, small sample sizes, historical control, random variability in cluster size, and cost constraints, etc. He has published multiple high quality papers in this area and in 2015 he co-authored a book titled “Sample Size Calculations on Clustered and Longitudinal Outcomes in Clinical Research” (Chapman & Hall, New York). Dr. Zhang has been successful in securing extramural grants as the PI to support his independent research program: an NIH R03 grant to conduct secondary data analysis on VA HIV registry in 2012; an NSF grant to build risk prediction model based on electronic health record data in 2013; and a PCORI methodology development grant to address pragmatic design issues in stepped-wedge cluster randomized trials in 2017.
- Graduate School
- Xiamen University - China , Econometrics
- Graduate School
- University of Missouri-Columbi (2005), Statistics
- Bayesian statistical methods
- Clinical trial design
- Missing data methods
- Multi-level models
- Autoantibodies and Disease Activity in Patients With Discoid Lupus Erythematosus.
- Kim A, O'Brien J, Tseng LC, Zhang S, Chong BF JAMA Dermatol 2014 Apr
- A Bayesian extension of the hypergeometric test for functional enrichment analysis.
- Cao J, Zhang S, Biometrics 2014 Mar 70 1 84-94
- Calculating sample size in trials using historical controls.
- Zhang S, Cao J, Ahn C Clin Trials 2010 Aug 7 4 343-53
- A Bayesian semiparametric survival model with longitudinal markers.
- Zhang S, Müller P, Do KA Biometrics 2010 Jun 66 2 435-43
- GO-Bayes: Gene Ontology-based overrepresentation analysis using a Bayesian approach.
- Zhang S, Cao J, Kong YM, Scheuermann RH Bioinformatics 2010 Apr 26 7 905-11
- Effects of correlation and missing data on sample size estimation in longitudinal clinical trials.
- Zhang S, Ahn C Pharm Stat 2010 Jan-Mar 9 1 2-9
- Association of Clinician Behaviors and Weight Change in School-Aged Children.
- Turer CB, Barlow SE, Sarwer DB, Adamson B, Sanders J, Ahn C, Zhang S, Flores G, Skinner CS, Am J Prev Med 2019 Sep 57 3 384-393
- Pediatric heterozygous familial hypercholesterolemia patients have locally increased aortic pulse wave velocity and wall thickness at the aortic root.
- Tran A, Burkhardt B, Tandon A, Blumenschein S, van Engelen A, Cecelja M, Zhang S, Uribe S, Mura J, Greil G, Hussain T, Int J Cardiovasc Imaging 2019 Jun
- Clinical and Sociobehavioral Prediction Model of 30-Day Hospital Readmissions Among People With HIV and Substance Use Disorder: Beyond Electronic Health Record Data.
- Nijhawan AE, Metsch LR, Zhang S, Feaster DJ, Gooden L, Jain MK, Walker R, Huffaker S, Mugavero MJ, Jacobs P, Armstrong WS, Daar ES, Sullivan M, Del Rio C, Halm EA J. Acquir. Immune Defic. Syndr. 2019 Mar 80 3 330-341
- Identifying Additional Risk Factors for Thrombosis and Pregnancy Morbidities Among Antiphospholipid Antibodies Carriers.
- Zuo Y, Fan J, Sarode R, Zhang S, Makris UE, Karp DR, Shen YM Clin. Appl. Thromb. Hemost. 2018 Sep 24 6 980-985
Sample Size Calculations for Clustered and Longitudinal Outcomes in Clinical Research
Chul Ahn, Moonseoung Heo, Song Zhang (2015). New York, Chapman and Hall/CRC
Optimal Biological Dose for Molecularly Targeted Therapies. In Wiley StatsRef: Statistics Reference Online
Chul Ahn, Seung-Ho Kang, Yang Xie, Song Zhang (2016). Hoboken, New Jersey., John Wiley & Sons
Honors & Awards
- Early Career Researcher and Postgraduate travel awards
International Society for Bayesian Analysis (2008)
- Graduate Professional Council Travel Scholarship
University of Missouri-Columbia (2004)
- Outstanding Performance in Doctoral Exams
Department of Statistics, University of Missouri-Columbia (2003)
- Excellent Student Award
Xiamen University, China (1999)
- Third Prize
College Student Science and Technology Thesis Competition, Fujian, China (1998)
- Eastern North American Region (ENAR) of the International Biometric Society (IBS)
- Institute of Mathematical Statistics
- The American Statistical Association