Dr. Zhang joined UT Southwestern as an assistant professor in September, 2007. He previously was a postdoctoral fellow at the University of Texas M.D. Anderson Cancer Center.
Dr. Zhang’s research interest in statistical methodology lies in two main areas: Bayesian hierarchical modeling and clinical trial design. He has published multiple papers on the application of Bayesian hierarchical models to disease mapping, joint modeling of longitudinal and survival outcomes, item-response theory for grant review, functional enrichment analysis to detect important pathways, and multi-level modeling to detect factors that impact cancer screening, etc. Another area of his research interest is design methodology for clinical trials to account for various pragmatic issues such as correlated outcomes (clustered and longitudinal), missing data, small sample sizes, historical control, random variability in cluster size, and cost constraints, etc. He has published multiple high quality papers in this area and in 2015 he co-authored a book titled “Sample Size Calculations on Clustered and Longitudinal Outcomes in Clinical Research” (Chapman & Hall, New York). Dr. Zhang has been successful in securing extramural grants as the PI to support his independent research program: an NIH R03 grant to conduct secondary data analysis on VA HIV registry in 2012; an NSF grant to build risk prediction model based on electronic health record data in 2013; and a PCORI methodology development grant to address pragmatic design issues in stepped-wedge cluster randomized trials in 2017.
- Graduate School
- Xiamen University - China , Econometrics
- Graduate School
- University of Missouri-Columbi (2005), Statistics
- Bayesian statistical methods
- Clinical trial design
- Missing data methods
- Multi-level models
- Sample Size Calculation for Clinical Trials with Correlated Count Measurements Based on the Negative Binomial Distribution
- D. Li, S. Zhang, J. Cao Statistics in Medicine 2019 Accepted
- Power Analysis for Cluster Randomized Trials with Multiple Binary Co-Primary Endpoints
- DT Li, J. Cao, S. Zhang Biometrics 2019 accepted
- Paired versus two-group experimental design for rheological studies of vocal fold tissues.
- Xu CC, Li D, Mau T, McPherson E, Du M, Zhang S, J Biomech 2019 01 83 150-156
- An investigation of left-right vocal fold symmetry in rheological and histological properties.
- Xu CC, Gao A, Zhang S Laryngoscope 2018 Aug
- Effect of Low-Dose Ferrous Sulfate vs Iron Polysaccharide Complex on Hemoglobin Concentration in Young Children With Nutritional Iron-Deficiency Anemia: A Randomized Clinical Trial.
- Powers JM, Buchanan GR, Adix L, Zhang S, Gao A, McCavit TL JAMA 2017 06 317 22 2297-2304
- Inference and sample size calculation for clinical trials with incomplete observations of paired binary outcomes.
- Zhang S, Cao J, Ahn C Stat Med 2016 Nov
- Prospective Longitudinal Analysis of 2-Hydroxyglutarate Magnetic Resonance Spectroscopy Identifies Broad Clinical Utility for the Management of Patients With IDH-Mutant Glioma.
- Choi C, Raisanen JM, Ganji SK, Zhang S, McNeil SS, An Z, Madan A, Hatanpaa KJ, Vemireddy V, Sheppard CA, Oliver D, Hulsey KM, Tiwari V, Mashimo T, Battiste J, Barnett S, Madden CJ, Patel TR, Pan E, Malloy CR, Mickey BE, Bachoo RM, Maher EA J. Clin. Oncol. 2016 Nov 34 33 4030-4039
- Sample size calculation for before-after experiments with partially overlapping cohorts.
- Zhang S, Cao J, Ahn C Contemp Clin Trials 2015 Sep
- Multiple comparison procedures.
- Cao J, Zhang S JAMA 2014 Aug 312 5 543-4
- Physicians, Clinics, and Neighborhoods: Multiple Levels of Influence on Colorectal Cancer Screening.
- Pruitt SL, Leonard T, Zhang S, Schootman M, Halm EA, Gupta S Cancer Epidemiol. Biomarkers Prev. 2014 Apr
Sample Size Calculations for Clustered and Longitudinal Outcomes in Clinical Research
Chul Ahn, Moonseoung Heo, Song Zhang (2015). New York, Chapman and Hall/CRC
Optimal Biological Dose for Molecularly Targeted Therapies. In Wiley StatsRef: Statistics Reference Online
Chul Ahn, Seung-Ho Kang, Yang Xie, Song Zhang (2016). Hoboken, New Jersey., John Wiley & Sons
Honors & Awards
- Early Career Researcher and Postgraduate travel awards
International Society for Bayesian Analysis (2008)
- Graduate Professional Council Travel Scholarship
University of Missouri-Columbia (2004)
- Outstanding Performance in Doctoral Exams
Department of Statistics, University of Missouri-Columbia (2003)
- Excellent Student Award
Xiamen University, China (1999)
- Third Prize
College Student Science and Technology Thesis Competition, Fujian, China (1998)
- Eastern North American Region (ENAR) of the International Biometric Society (IBS)
- Institute of Mathematical Statistics
- The American Statistical Association