Education
Undergraduate
Wuhan University (1995), Biology
Graduate School
Albert Einstein College of Med (2003), Cell Biology

Research Interest
  • Signal transduction
  • Structural biology

Publications

Featured Publications LegendFeatured Publications

Secondary PDZ domain-binding site on class B plexins enhances the affinity for PDZ-RhoGEF.
Pascoe HG, Gutowski S, Chen H, Brautigam CA, Chen Z, Sternweis PC, Zhang X Proc. Natl. Acad. Sci. U.S.A. 2015 Dec 112 48 14852-7
Structural basis for activation and non-canonical catalysis of the Rap GTPase activating protein domain of plexin
Wang Y, Pascoe HG, Brautigam CA, He H, Zhang X. eLife 2013 2 e01279
Plexins Are GTPase-Activating Proteins for Rap and Are Activated by Induced Dimerization.
Wang Y, He H, Srivastava N, Vikarunnessa S, Chen YB, Jiang J, Cowan CW, Zhang X Sci Signal 2012 5 207 ra6
Crystal structure of the plexin A3 intracellular region reveals an autoinhibited conformation through active site sequestration.
He H, Yang T, Terman JR, Zhang X Proc. Natl. Acad. Sci. U.S.A. 2009 Sep 106 37 15610-5
Class A Plexins Are Organized as Preformed Inactive Dimers on the Cell Surface.
Marita M, Wang Y, Kaliszewski MJ, Skinner KC, Comar WD, Shi X, Dasari P, Zhang X, Smith AW Biophys. J. 2015 Nov 109 9 1937-45
Structural basis for the prion-like MAVS filaments in antiviral innate immunity.
Xu H, He X, Zheng H, Huang LJ, Hou F, Yu Z, de la Cruz MJ, Borkowski B, Zhang X, Chen ZJ, Jiang QX Elife 2014 3 e01489
Identification of beryllium-dependent peptides recognized by CD4+ T cells in chronic beryllium disease.
Falta MT, Pinilla C, Mack DG, Tinega AN, Crawford F, Giulianotti M, Santos R, Clayton GM, Wang Y, Zhang X, Maier LA, Marrack P, Kappler JW, Fontenot AP J. Exp. Med. 2013 Jun
Structural Basis for Autoinhibition of the Guanine Nucleotide Exchange Factor FARP2.
He X, Kuo YC, Rosche TJ, Zhang X Structure 2013 Mar 21 3 355-64
Oncogenic mutations counteract intrinsic disorder in the EGFR kinase and promote receptor dimerization.
Shan Y, Eastwood MP, Zhang X, Kim ET, Arkhipov A, Dror RO, Jumper J, Kuriyan J, Shaw DE Cell 2012 May 149 4 860-70
Catalytic control in the EGF receptor and its connection to general kinase regulatory mechanisms.
Jura N, Zhang X, Endres NF, Seeliger MA, Schindler T, Kuriyan J Mol. Cell 2011 Apr 42 1 9-22

Honors & Awards
  • Virginia Murchison Linthicum Scholar in Medical Research
    UT Southwestern Medical Center (2007)
  • Julius Marmur Research Award
    Albert Einstein School of Medicine (2002)