Shwu-Yuan Wu, Ph.D.

Graduate School

Yang-Ming Medical College - Ch (1986), Biochemistry

Graduate School

University of Rochester (1993), Biochemistry

• Chromatin and Epigenetics
• Human Papillomaviruses
• p53 Tumor Supressor Protein
• Post-Translational Modifications
• Transcription and Gene Regulation

Featured Publications

Brd4 links chromatin targeting to HPV transcriptional silencing

Wu, S.-Y., A.Y. Lee, S.Y. Hou, J.K. Kemper, H. Erdjument-Bromage, P. Tempst, and C.-M. Chiang Genes Dev. 2006 20 2383-2396

Human Mediator enhances activator-facilitated recruitment of RNA polymerase II and promoter recognition by TATA-binding protein (TBP) independently of TBP-associated factors

Wu, S.-Y., T. Zhou, and C.-M. Chiang Mol. Cell. Biol. 2003 23 6229-6242

TATA-binding protein-associated factors enhance the recruitment of RNA polymerase II by transcriptional activators

Wu, S.-Y. and C.-M. Chiang J. Biol. Chem. 2001 276 34235-34243

Isolation of mouse TFIID and functional characterization of TBP and TFIID in mediating estrogen receptor and chromatin transcription

Wu, S.-Y., M.C. Thomas, S.Y. Hou, V. Likhite, and C.-M. Chiang J. Biol. Chem. 1999 274 23480-23490

TAFII-independent activation mediated by human TBP in the presence of the positive cofactor PC4

Wu, S.-Y., E. Kershnar, and C.-M. Chiang EMBO J. 1998 17 4478-4490

The double bromodomain-containing chromatin adaptor Brd4 and transcriptional regulation

Wu, S.-Y. and C.-M. Chiang J. Biol. Chem. 2007 282 13141-13145

CTCF interacts with and recruits the largest subunit of RNA polymerase II to CTCF target sites genome-wide

Chernukhin, I., S. Shamsuddin, S.Y. Kang, R. Bergstrom, Y.-W. Kwon, W. Yu, J. Whitehead, R. Mukhopadhyay, F. Docquier, D. Farrar, I. Morrison, M. Vigneron, S.-Y. Wu, C.-M. Chiang, D. Loukinov, V. Lobanenkov, and E. Klenova Mol. Cell. Biol. 2007 27 1631-1648

Recruitment of TFIIH to the HIV LTR is a rate-limiting step in the emergency of HIV from latency

Kim, Y.K., C.F. Bourgeois, R. Pearson, M. Tyagi, M.J. West, J. Wong, S.-Y. Wu, C.-M. Chiang, and J. Karn EMBO J. 2006 25 3596-3604

Dynamic localization of the human papillomavirus type 11 origin binding protein E2 through mitosis while in association with the spindle apparatus

Dao, L.D., A. Duffy, B.A. Van Tine, S.-Y. Wu, C.-M. Chiang, T.R. Broker, and L.T. Chow J. Virol. 2006 80 4792-4800

SREBP-1c and Sp1 interact to regulate transcription of the gene for phosphoenolpyruvate carboxykinase (GTP) in the liver

Chakravarty, K., S.-Y. Wu, C.-M. Chiang, D. Samols, and R.W. Hanson J. Biol. Chem. 2004 279 15385-15395

• Postdoctoral Fellow
  Aaron Diamond Foundation (1995)
• Elon Huntington Hooker Graduate Fellowship
  University of Rochester (1993)