John Mansour, M.D., treats patients with malignancies of the stomach, pancreas, liver, bile duct, and other abdominal organs, as well as the diverse population of sarcoma patients.

A Cleveland native, Dr. Mansour earned his medical degree at Case Western Reserve University, and he completed a residency in surgery at the University of Wisconsin Hospital and Clinics. He then received advanced training in surgical oncology and upper GI and hepatopancreatobiliary malignancy through a fellowship at Memorial Sloan Kettering Cancer Center.

Board-certified in surgery by the American College of Surgeons, he joined UT Southwestern in 2007. 

Dr. Mansour has been a guest lecturer at international, national, regional, and local medical conferences. His research has been published in numerous medical journals, including the Annals of Surgical Oncology and Journal of the American College of Surgeons. He is an ad hoc reviewer for the Journal of Surgical Oncology, Annals of Surgery, HPB Journal, Archives of Surgery, and Journal of the American College of Surgeons.

Dr. Mansour was selected by his national peers to serve on the American Board of Surgery with the Complex General Surgical Oncology Board where he focuses on the standards and expectations for formal certification of surgeons specializing in Surgical Oncology.

He is a member of the Americas Hepato-Pancreato-Biliary Association, the Society of Surgical Oncology, the American Society of Clinical Oncology, and the Association for Academic Surgery.

Dr. Mansour has been included in D Magazine's Best Doctors list for over 10 years running.


Medical School
Case Western Reserve University School of Medicine (1999)
University of Wisconsin Hospital and Clinics (2005), Surgery
Memorial Sloan Kettering Cancer Institute (2007), Surgical Oncology

Research Interest

  • Individualized cancer care
  • Multimodality treatment of gastrointestinal, pancreatic, and hepatic malignancy
  • Safety and Quality in Surgical Care


Featured Publications LegendFeatured Publications

Pathologic response to preoperative therapy: does it mean what we think it means
Mansour JC, Schwarz RE Annals of Surgical Oncology March 2009 16(6) 1465-79
Molecular Mechanisms for Individualized Cancer Care
Mansour, JC and Schwarz RE Journal of the American College of Surgeons August 2008 207(2) 250-8
Does graded histologic response after neoadjuvant treatment predict survival for completely resected gastric cancer?
Mansour JC, Tang L, Shah M, Bentrem D, Klimstra D, Gonen M, Brennan M, Coit D Annals of Surgical Oncology October 2007 October-Epub
Timing of the liver resection for patients with synchronous metastases: practical and outcome considerations
Mansour JC, Fong Y Annals of Surgical Oncoloy June 2007
The utility of F-18 fluorodeoxyglucose whole body PET imaging for determining malignancy in cystic lesions of the pancreas
Mansour JC, Pandit-Taskar N, Schwartz L, D?Angelica M, Fong Y, Larson SM, Brennan MF, Allen, PJ Journal of Gastrointestinal Surgery 2006 10(10) 1354-60

Honors & Awards

  • Alpha Omega Alpha Association
    National Medical Honor Society recognizing educational achievement, teaching, humanism, and professionalism (2018-2018)
  • Gold Humanism Honor Society
    National organization recognizes faculty who are exemplars of compassionate patient care and who serve as role models, mentors, and leaders in medicine. (2018-2018)
  • Patricia and William L. Watson Jr., Award for Excellence in Clinical
    The institutions highest honor for clinical excellence (2017-2018)
  • D Magazine Best Doctor
  • Multiple Medical Student and Resident Teacher Award

Professional Associations/Affiliations

  • American Board of Surgery, Complex General Surgical Oncology Board (1999)
  • American College of Surgeons
  • American Society of Clinical Oncology
  • Association for Academic Surgery
  • Society of Surgical Oncology