Cheng-Ming Chiang, Ph.D.

Cheng-Ming Chiang was born in Taipei, Taiwan, in 1961. He received his B.S. from the Department of Agricultural Chemistry, National Taiwan University in 1984, and his Ph.D. from the Department of Biochemistry, University of Rochester in 1991. His doctoral dissertation was supervised by Professors Louise Chow and Thomas Broker. After finishing his postdoctoral training with Professor Robert Roeder at Rockefeller University, he took a faculty position in the Department of Biochemistry at University of Illinois, Urbana-Champaign in 1995. In 2000, he moved to Department of Biochemistry at Case Western Reserve University as tenured Associate Professor. Dr. Chiang accepted a Professorship at UT Southwestern and relocated his laboratory to UTSW in July 2007.

Dr. Chiang is a 1996 Pew Scholar and has been an editorial board member of the Journal of Biological Chemistry and Faculty of 1000 since 2003. He has been a regular member for American Cancer Society Genetic/DNA Mechanisms in Cancer, National Institutes of Health Virology B, and Human Frontier Science Program study sections. His research interests span transcription, chromatin, gene regulation, post-translational modification, molecular virology (particularly human papillomavirus), cancer biology, and therapeutic compound development.

Undergraduate

Unlisted - International Colle , Chemistry

Graduate School

University of Rochester , Biochemistry

• Brd4 in Epigenetic Control and Cancer Therapeutics
• Chromatin Transcription and Posttranslational Modification
• Gene Regulation in Human Papillomaviruses (HPVs)
• Human General Transcription Factors and Cofactors in Eukaryotic Transcription
• p53 Tumor Suppressor Function and Regulation
• Therapeutics targeting Phospho-BRD4

Featured Publications

Targeted mRNA demethylation using an engineered dCas13b-ALKBH5 fusion protein.

Li J, Chen Z, Chen F, Xie G, Ling Y, Peng Y, Lin Y, Luo N, Chiang CM, Wang H, Nucleic Acids Res. 2020 Jun 48 10 5684-5694

KAP1 Is a Chromatin Reader that Couples Steps of RNA Polymerase II Transcription to Sustain Oncogenic Programs.

Bacon CW, Challa A, Hyder U, Shukla A, Borkar AN, Bayo J, Liu J, Wu SY, Chiang CM, Kutateladze TG, D'Orso I, Mol. Cell 2020 May

Opposing Functions of BRD4 Isoforms in Breast Cancer.

Wu SY, Lee CF, Lai HT, Yu CT, Lee JE, Zuo H, Tsai SY, Tsai MJ, Ge K, Wan Y, Chiang CM, Mol. Cell 2020 May

PCAF-mediated acetylation of ISX recruits BRD4 to promote epithelial-mesenchymal transition.

Wang LT, Liu KY, Jeng WY, Chiang CM, Chai CY, Chiou SS, Huang MS, Yokoyama KK, Wang SN, Huang SK, Hsu SH, EMBO Rep. 2020 Jan e48795

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

Kim JJ, Lee SY, Gong F, Battenhouse AM, Boutz DR, Bashyal A, Refvik ST, Chiang CM, Xhemalce B, Paull TT, Brodbelt JS, Marcotte EM, Miller KM, Genes Dev. 2019 Nov

Time series modeling of cell cycle exit identifies Brd4 dependent regulation of cerebellar neurogenesis.

Penas C, Maloof ME, Stathias V, Long J, Tan SK, Mier J, Fang Y, Valdes C, Rodriguez-Blanco J, Chiang CM, Robbins DJ, Liebl DJ, Lee JK, Hatten ME, Clarke J, Ayad NG, Nat Commun 2019 Jul 10 1 3028

Inhibition of BRD4 suppresses the malignancy of breast cancer cells via regulation of Snail.

Lu L, Chen Z, Lin X, Tian L, Su Q, An P, Li W, Wu Y, Du J, Shan H, Chiang CM, Wang H, Cell Death Differ. 2019 May

Transforming activity of an oncoprotein-encoding circular RNA from human papillomavirus.

Zhao J, Lee EE, Kim J, Yang R, Chamseddin B, Ni C, Gusho E, Xie Y, Chiang CM, Buszczak M, Zhan X, Laimins L, Wang RC, Nat Commun 2019 05 10 1 2300

SUMO suppresses and MYC amplifies transcription globally by regulating CDK9 sumoylation.

Yu F, Shi G, Cheng S, Chen J, Wu SY, Wang Z, Xia N, Zhai Y, Wang Z, Peng Y, Wang D, Du JX, Liao L, Duan SZ, Shi T, Cheng J, Chiang CM, Li J, Wong J Cell Res. 2018 Mar

BRD4 Promotes DNA Repair and Mediates the Formation of TMPRSS2-ERG Gene Rearrangements in Prostate Cancer.

Li X, Baek G, Ramanand SG, Sharp A, Gao Y, Yuan W, Welti J, Rodrigues DN, Dolling D, Figueiredo I, Sumanasuriya S, Crespo M, Aslam A, Li R, Yin Y, Mukherjee B, Kanchwala M, Hughes AM, Halsey WS, Chiang CM, Xing C, Raj GV, Burma S, de Bono J, Mani RS Cell Rep 2018 Jan 22 3 796-808

 Featured Books

Identification of alternatively spliced mRNAs and localization of 5' ends by polymerase chain reaction amplification. In Methods in Molecular Biology (Vol. 16): PCR Protocols: Current Methods and Applications

Chiang, C.-M., L.T. Chow, and T.R. Broker (1993). Humana Inc.

Expression and purification of epitope-tagged multisubunit protein complexes from mammalian cells. In Current Protocols in Molecular Biology

Wu, S.-Y. and C.-M. Chiang (2001).

Update to: Establishment of Stable Cell Lines Expressing Potentially toxic Proteins by tetracycline-Regulated and Epitope-Tagging Methods. In Cloning and Expression Vectors for Protein Studies

Hou, S.Y., S.-Y. Wu, and C.-M. Chiang (2001). Eaton Book Publishing

The general transcription machinery and preinitiation complex formation. In Gene Expression and Regulation

Hou, S.Y. and C.-M. Chiang (2006). Higher Education Press (Beijing) & Springer

General Cofactors: TFIID, Mediator and USA. In Gene Expression and Regulation

Thomas, M.C. and C.-M. Chiang (2006). Higher Education Press (Beijing) & Springer

• F1000 “Faculty Member of the Year” Award in Cell Biology
  F1000Prime (2019)
• F1000 “Faculty Member of the Year” Award in Cell Biology
  F1000Prime (2018)
• F1000 “Faculty Member of the Year” Award in Cell Biology
  F1000Prime (2017)
• Mt. Sinai Health Care Foundation Scholar
  Case Western Reserve University (2000)
• Pew Scholar in the Biomedical Sciences
  Pew Charitable Trust (1996)
• Postdoctoral Fellow
  Helen Hay Whitney Foundation (1993)
• Postdoctoral Fellow
  Aaron Diamond Foundation (1993)
• The Wallace O. Fenn Award
  University of Rochester (1991)
• The Walter Bloor Award
  University of Rochester (1991)

• Case Western Reserve University, Cleveland, Ohio (2000-2007)
• Rockefeller University, New York, New York (1992-1995)
• University of Illinois at Urbana-Champaign, Urbana, Illinois (1995-2000)
• University of Rochester, Rochester, New York (1987-1991)
• University of Texas Southwestern Medical Center, Dallas, Texas (2007)