Cheng-Ming Chiang was born in Taipei, Taiwan, in 1961. He received his B.S. from the Department of Agricultural Chemistry, National Taiwan University, in 1984, and his Ph.D. from the Department of Biochemistry, University of Rochester, in 1991. His doctoral dissertation was supervised by Professors Louise Chow and Thomas Broker. After finishing his postdoctoral training with Professor Robert Roeder at Rockefeller University, he took a faculty position in the Department of Biochemistry at University of Illinois, Urbana-Champaign in 1995. In 2000, he moved to Department of Biochemistry at Case Western Reserve University as tenured Associate Professor.
Dr. Chiang accepted a Professorship at UT Southwestern and relocated his laboratory to UT Southwestern in July 2007.
Dr. Chiang is a 1996 Pew Scholar and has been an editorial board member of the Journal of Biological Chemistry and Faculty of 1000 since 2003. He has been a regular member for American Cancer Society Genetic/DNA Mechanisms in Cancer, National Institutes of Health Virology B, and Human Frontier Science Program study sections. His research interests span transcription, chromatin, gene regulation, and virology.
- Brd4 in Epigenetic Control and Cancer Therapeutics
- Chromatin Transcription and Posttranslational Modification
- Gene Regulation in Human Papillomaviruses (HPVs)
- Human General Transcription Factors and Cofactors in Eukaryotic Transcription
- p53 Tumor Suppressor Function and Regulation
- Involvement of Brd4 in different steps of the papillomavirus life cycle.
- Iftner T, Haedicke-Jarboui J, Wu SY, Chiang CM Virus Res. 2016 Dec
- BRD4 Phosphorylation Regulates HPV E2-Mediated Viral Transcription, Origin Replication, and Cellular MMP-9 Expression.
- Wu SY, Nin DS, Lee AY, Simanski S, Kodadek T, Chiang CM Cell Rep 2016 Aug 16 6 1733-48
- Phospho-BRD4: transcription plasticity and drug targeting.
- Chiang CM Drug Discov Today Technol 2016 Mar 19 17-22
- Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer.
- Shu S, Lin CY, He HH, Witwicki RM, Tabassum DP, Roberts JM, Janiszewska M, Huh SJ, Liang Y, Ryan J, Doherty E, Mohammed H, Guo H, Stover DG, Ekram MB, Peluffo G, Brown J, D'Santos C, Krop IE, Dillon D, McKeown M, Ott C, Qi J, Ni M, Rao PK, Duarte M, Wu SY, Chiang CM, Anders L, Young RA, Winer EP, Letai A, Barry WT, Carroll JS, Long HW, Brown M, Liu XS, Meyer CA, Bradner JE, Polyak K Nature 2016 Jan 529 7586 413-7
- Papillomavirus-Associated Tumor Formation Critically Depends on c-Fos Expression Induced by Viral Protein E2 and Bromodomain Protein Brd4.
- Delcuratolo M, Fertey J, Schneider M, Schuetz J, Leiprecht N, Hudjetz B, Brodbeck S, Corall S, Dreer M, Schwab RM, Grimm M, Wu SY, Stubenrauch F, Chiang CM, Iftner T PLoS Pathog. 2016 Jan 12 1 e1005366
- Critical role of RanBP2-mediated SUMOylation of Small Heterodimer Partner in maintaining bile acid homeostasis.
- Kim DH, Kwon S, Byun S, Xiao Z, Park S, Wu SY, Chiang CM, Kemper B, Kemper JK Nat Commun 2016 7 12179
- Regulation of mammalian transcription and splicing by Nuclear RNAi.
- Kalantari R, Chiang CM, Corey DR Nucleic Acids Res. 2015 Nov
- Bromodomain Protein BRD4 Is Required for Estrogen Receptor-Dependent Enhancer Activation and Gene Transcription.
- Nagarajan S, Hossan T, Alawi M, Najafova Z, Indenbirken D, Bedi U, Taipaleenmäki H, Ben-Batalla I, Scheller M, Loges S, Knapp S, Hesse E, Chiang CM, Grundhoff A, Johnsen SA Cell Rep 2014 Jul 8 2 460-9
- Nonequivalent Response to Bromodomain-Targeting BET Inhibitors in Oligodendrocyte Cell Fate Decision.
- Chiang CM Chem. Biol. 2014 Jul 21 7 804-6
- Brd4 is displaced from HPV replication factories as they expand and amplify viral DNA.
- Sakakibara N, Chen D, Jang MK, Kang DW, Luecke HF, Wu SY, Chiang CM, McBride AA PLoS Pathog. 2013 Nov 9 11 e1003777
Identification of alternatively spliced mRNAs and localization of 5' ends by polymerase chain reaction amplification. In Methods in Molecular Biology (Vol. 16): PCR Protocols: Current Methods and Applications
Chiang, C.-M., L.T. Chow, and T.R. Broker (1993). Humana Inc.
Expression and purification of epitope-tagged multisubunit protein complexes from mammalian cells. In Current Protocols in Molecular Biology
Wu, S.-Y. and C.-M. Chiang (2001).
Update to: Establishment of Stable Cell Lines Expressing Potentially toxic Proteins by tetracycline-Regulated and Epitope-Tagging Methods. In Cloning and Expression Vectors for Protein Studies
Hou, S.Y., S.-Y. Wu, and C.-M. Chiang (2001). Eaton Book Publishing
The general transcription machinery and preinitiation complex formation. In Gene Expression and Regulation
Hou, S.Y. and C.-M. Chiang (2006). Higher Education Press (Beijing) & Springer
General Cofactors: TFIID, Mediator and USA. In Gene Expression and Regulation
Thomas, M.C. and C.-M. Chiang (2006). Higher Education Press (Beijing) & Springer
Honors & Awards
- Mt. Sinai Health Care Foundation Scholar
Case Western Reserve University (2000)
- Pew Scholar in the Biomedical Sciences
Pew Charitable Trust (1996)
- Postdoctoral Fellow
Helen Hay Whitney Foundation (1993)
- Postdoctoral Fellow
Aaron Diamond Foundation (1993)
- The Wallace O. Fenn Award
University of Rochester (1991)
- The Walter Bloor Award
University of Rochester (1991)
- University of Texas Southwestern Medical Center, Dallas, Texas (2007)
- Case Western Reserve University, Cleveland, Ohio (2000-2007)
- University of Illinois at Urbana-Champaign, Urbana, Illinois (1995-2000)
- Rockefeller University, New York, New York (1992-1995)
- University of Rochester, Rochester, New York (1987-1991)