Nicholas Conrad, Ph.D.

Graduate School

Johns Hopkins University (2002), Biochemistry

• Intron Retention
• KSHV gene expression
• RNA decay
• RNA methylation

Featured Publications

SAM homeostasis is regulated by CFI_m-mediated splicing of MAT2A.

Scarborough AM, Flaherty JN, Hunter OV, Liu K, Kumar A, Xing C, Tu BP, Conrad NK, Elife 2021 May 10

Kaposi's Sarcoma-Associated Herpesvirus Fine-Tunes the Temporal Expression of Late Genes by Manipulating a Host RNA Quality Control Pathway.

Ruiz JC, Devlin AM, Kim J, Conrad NK, J Virol 2020 07 94 14

Kaposi's sarcoma-associated herpesvirus ORF57 protein protects viral transcripts from specific nuclear RNA decay pathways by preventing hMTR4 recruitment.

Ruiz JC, Hunter OV, Conrad NK, PLoS Pathog. 2019 02 15 2 e1007596

Balance between MAT2A intron detention and splicing is determined co-transcriptionally.

Pendleton KE, Park SK, Hunter OV, Bresson SM, Conrad NK RNA 2018 Mar

A Conserved Splicing Silencer Dynamically Regulates O-GlcNAc Transferase Intron Retention and O-GlcNAc Homeostasis.

Park SK, Zhou X, Pendleton KE, Hunter OV, Kohler JJ, O'Donnell KA, Conrad NK Cell Rep 2017 Aug 20 5 1088-1099

The U6 snRNA m(6)A Methyltransferase METTL16 Regulates SAM Synthetase Intron Retention.

Pendleton KE, Chen B, Liu K, Hunter OV, Xie Y, Tu BP, Conrad NK Cell 2017 May 169 5 824-835.e14

Canonical Poly(A) Polymerase Activity Promotes the Decay of a Wide Variety of Mammalian Nuclear RNAs.

Bresson SM, Hunter OV, Hunter AC, Conrad NK PLoS Genet. 2015 Oct 11 10 e1005610

New insights into the expression and functions of the Kaposi's sarcoma-associated herpesvirus long noncoding PAN RNA.

Conrad NK Virus Res. 2015 Jun

HITS-CLIP analysis uncovers a link between the Kaposi's sarcoma-associated herpesvirus ORF57 protein and host pre-mRNA metabolism.

Sei E, Wang T, Hunter OV, Xie Y, Conrad NK PLoS Pathog. 2015 Feb 11 2 e1004652

Depletion of REF/Aly alters gene expression and reduces RNA polymerase II occupancy.

Stubbs SH, Conrad NK Nucleic Acids Res. 2015 Jan 43 1 504-19