Shaheen Khan, Ph.D.

EDUCATION

Undergraduate

St. Xavier's College, Mumbai, India (1999), Lifesciences/Biochemistry

Graduate School

Texas A&M University (2005), Genetics

• Autoimmunity
• Cancer Immunotherapy
• Single Cell Genomics

Featured Publications

Autoimmunity, Checkpoint Inhibitor Therapy and Immune-related Adverse Events: A Review.

Khan S, Gerber DE, Semin. Cancer Biol. 2019 Jul

Immune dysregulation in cancer patients developing immune-related adverse events.

Khan S, Khan SA, Luo X, Fattah FJ, Saltarski J, Gloria-McCutchen Y, Lu R, Xie Y, Li Q, Wakeland E, Gerber DE Br. J. Cancer 2018 Oct

Melanoma models for the next generation of therapies.

Patton EE, Mueller KL, Adams DJ, Anandasabapathy N, Aplin AE, Bertolotto C, Bosenberg M, Ceol CJ, Burd CE, Chi P, Herlyn M, Holmen SL, Karreth FA, Kaufman CK, Khan S, Kobold S, Leucci E, Levy C, Lombard DB, Lund AW, Marie KL, Marine JC, Marais R, McMahon M, Robles-Espinoza CD, Ronai ZA, Samuels Y, Soengas MS, Villanueva J, Weeraratna AT, White RM, Yeh I, Zhu J, Zon LI, Hurlbert MS, Merlino G, Cancer Cell 2021 Feb

Investigational Biomarkers for Checkpoint Inhibitor Immune-Related Adverse Event Prediction and Diagnosis.

von Itzstein MS, Khan S, Gerber DE, Clin. Chem. 2020 Jun 66 6 779-793

Statin Intolerance, anti-HMGCR Antibodies, and Immune Checkpoint Inhibitor-Associated Myositis: A "Two-Hit" Autoimmune Toxicity or Clinical Predisposition?

von Itzstein MS, Khan S, Popat V, Lu R, Khan SA, Fattah FJ, Park JY, Bermas BL, Karp DR, Ahmed M, Saltarski JM, Gloria-McCutchen Y, Xie Y, Li QZ, Wakeland EK, Gerber DE, Oncologist 2020 May

Late-Onset Immunotherapy Toxicity and Delayed Autoantibody Changes: Checkpoint Inhibitor-Induced Raynaud's-Like Phenomenon.

Khan S, von Itzstein MS, Lu R, Bermas BL, Karp DR, Khan SA, Fattah FJ, Park JY, Saltarski JM, Gloria-McCutchen Y, Xie Y, Li QZ, Wakeland EK, Gerber DE, Oncologist 2020 Mar

FOXN1 compound heterozygous mutations cause selective thymic hypoplasia in humans.

Du Q, Huynh LK, Coskun F, Molina E, King MA, Raj P, Khan S, Dozmorov I, Seroogy CM, Wysocki CA, Padron GT, Yates TR, Markert ML, de la Morena MT, van Oers NS, J. Clin. Invest. 2019 Sep

MIR205HG Is a Long Noncoding RNA that Regulates Growth Hormone and Prolactin Production in the Anterior Pituitary.

Du Q, Hoover AR, Dozmorov I, Raj P, Khan S, Molina E, Chang TC, de la Morena MT, Cleaver OB, Mendell JT, van Oers NSC, Dev. Cell 2019 Apr

Single-Cell RNA-Sequencing of Peripheral Blood Mononuclear Cells with ddSEQ.

Khan S, Kaihara KA, Methods Mol. Biol. 2019 1979 155-176

DNA polymerase-a regulates the activation of type I interferons through cytosolic RNA:DNA synthesis.

Starokadomskyy P, Gemelli T, Rios JJ, Xing C, Wang RC, Li H, Pokatayev V, Dozmorov I, Khan S, Miyata N, Fraile G, Raj P, Xu Z, Xu Z, Ma L, Lin Z, Wang H, Yang Y, Ben-Amitai D, Orenstein N, Mussaffi H, Baselga E, Tadini G, Grunebaum E, Sarajlija A, Krzewski K, Wakeland EK, Yan N, de la Morena MT, Zinn AR, Burstein E Nat. Immunol. 2016 Mar

 Featured Books

: Chemical-induced estrogenecity.. In Veterinary Toxicology: Basic and Clinical Principles by Ramesh C. Gupta.

Stephen H. Safe, Shaheen Khan, Fei Wu, and Xiangrong Li. (2007).

Single-cell RNA-sequencing of Peripheral Blood Mononuclear Cells with ddSEQ. In Single Cell Methods: Sequencing and Proteomics by Valentina Proserpio

Shaheen Khan and Kelly A Kaihara (2019). Springer Protocols

• The MRA-SITC Young Investigator Award in Immune-related Adverse Events
  (2019)
• The George T. EDDS Award for Outstanding Graduate Student, Texas A&M University, College Station. TX
  (2005)
• Department of Defense Predoctoral traineeship grant
  Breast Cancer Research Grant (2002-2005)
• Scholarship for Academic Excellence
  (1992)

• American Association for Cancer Research (2004)
• The American Association of Immunologists (2017)
• The American Society of Human Genetics (2010)
• The Society for Immunotherapy of Cancer (2019)