Biography

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Dr. Brion's current research interest is focused on improving nutrition and growth in very preterm and very low birth weight infants. He has obtained funding from Children’s Medical Center Foundation at Dallas and from the Gerber Foundation. His research and quality improvement projects address the relationship between neonatal nutrition, growth, neurodevelopment and signs suggestive of metabolic syndrome in high-risk preterm infants. Specifically, valid serial length measurements in preterm infants were shown to permit characterization of growth patterns. Adjustable feedings plus accurate serial length measurements decreased weight-length disproportion at discharge in very preterm infants. In preterm infants fed human milk, milk fortification can be adjusted by 1) optimization, based on growth rate and serum analyses, or 2) individualization, based on daily human milk nutrient analysis. Randomized allocation to adjusting macronutrients based on breast milk analysis in preterm neonates did not improve weight gain, linear growth or weight/length disproportion at 36 weeks postmentrual age or discharge. Long-term follow-up of these infants is now in process to assess the development of signs of metabolic syndrome and neurodevelopment. The next step in quality improvement aims at decreasing the frequency of growth failure and necrotizing enterocolitis.

Dr. Brion has published more than 70 original research manuscripts. During his training in pediatrics and in neonatology, he participated and conducted studies on growth, nutrition and assessment of renal function in neonates and children. As Faculty at the Albert Einstein College of Medicine in New York (AECOM), he was funded for years by the NIH, American Heart Association, Genentech Foundation, and Pharmacia for basic sciences research in developmental nephrology, specifically renal acid secretion, carbonic anhydrase, pathophysiological effects of acidosis and growth.

Dr. Brion’s academic focus later changed to clinical research assessing neonatal mortality and morbidity and evidence-based medicine. He is a member of the Neonatal Cochrane Collaboration Group. He has authored several Cochrane reviews and has participated in 3 randomized controlled trials (RCTs) in preterm infants. Dr. Brion has served on the IRB at AECOM. He has participated in several multi-center research studies. Since 2009, he has been the University of Texas Southwestern (UTSW) Alternate PI for the NICHD Eunice Kennedy Shriver Cooperative Multicenter Neonatal Research Network (NRN). Dr. Brion serves on the subcommittee on protection of human subjects of the NRN, is co-investigator in 3 protocols in the pipeline, and has reviewed 4 manuscripts. He has co-authored manuscripts published by the NRN: one pilot randomized trial on vitamin E, and one study that showed changes in practice after a randomized trial and one randomized trial on inositol. 

Dr. Brion was Director of the Fellowship Training Program in Neonatal-Perinatal Medicine at AECOM in 1997-2006 and Director of the Fellowship Training Program in Neonatal-Perinatal Medicine at UTSW in 2007-2019. He has been research mentor for more than 25 trainees. He is one of 3 neonatologists who teach an evidence-based medicine course twice a month for Fellows in Neonatal-Perinatal Medicine at UTSW. This course includes an evidence-based decision making series.

In 2013 Dr. Brion took the Clinical Safety and Efficacy Course at UTSW. He supervises a team of research nurses who maintain the Divisional extensive neonatal intensive care unit (NICU) clinical databases at Parkland and Children’s Medical Center and databases for the Vermont Oxford Neonatal Network (VON) and Children’s Hospital Network Database (CHND). He compiles and presents an Annual Report of mortality and morbidity of neonates admitted to Parkland NICU and compares them to those of the NICHD NRN, VON and national data. He has used the databases for quality improvement and for research, including preliminary data for the proposed research.

 

Education

Medical School
Universite Libre de Bruxelles (1976)
Residency
Hopital Universitaire Saint-Pierre (1979), Pediatrics
Residency
Institut Edith Cavell (1981), Pediatrics
Fellowship
Hospital for Sick Children (1982), Neonatal-perinatal Medicine
Fellowship
Institut Edith Cavell (1982), Neonatal-perinatal Medicine
Fellowship
Cliniques Universitaires (1983), Neonatal-perinatal Medicine
Fellowship
Albert Einstein College of Medicine/Montefiore Medical Center (1985), Neonatal-perinatal Medicine
Residency
Montefiore Medical Center/ Albert Einstein College of Medicine (1986), Pediatrics

Research Interest

  • Evidence-based medicine
  • Interventions to reduce mortality and morbidity in neonates
  • Neonatal nutrition and growth

Publications

Featured Publications LegendFeatured Publications

Markers of Successful Extubation in Extremely Preterm Infants, and Morbidity After Failed Extubation.
Chawla S, Natarajan G, Shankaran S, Carper B, Brion LP, Keszler M, Carlo WA, Ambalavanan N, Gantz MG, Das A, Finer N, Goldberg RN, Cotten CM, Higgins RD J. Pediatr. 2017 Jun
Association between Use of Prophylactic Indomethacin and the Risk for Bronchopulmonary Dysplasia in Extremely Preterm Infants.
Jensen EA, Dysart KC, Gantz MG, Carper B, Higgins RD, Keszler M, Laughon MM, Poindexter BB, Stoll BJ, Walsh MC, Schmidt B J. Pediatr. 2017 Feb
Survival and Neurodevelopmental Outcomes among Periviable Infants.
Younge N, Goldstein RF, Bann CM, Hintz SR, Patel RM, Smith PB, Bell EF, Rysavy MA, Duncan AF, Vohr BR, Das A, Goldberg RN, Higgins RD, Cotten CM N. Engl. J. Med. 2017 02 376 7 617-628
Severe intraventricular hemorrhage and withdrawal of support in preterm infants.
Sheehan JW, Pritchard M, Heyne RJ, Brown LS, Jaleel MA, Engle WD, Burchfield PJ, Brion LP J Perinatol 2016 Dec
Growth Outcomes of Preterm Infants Exposed to Different Oxygen Saturation Target Ranges from Birth.
Navarrete CT, Wrage LA, Carlo WA, Walsh MC, Rich W, Gantz MG, Das A, Schibler K, Newman NS, Piazza AJ, Poindexter BB, Shankaran S, Sánchez PJ, Morris BH, Frantz ID, Van Meurs KP, Cotten CM, Ehrenkranz RA, Bell EF, Watterberg KL, Higgins RD, Duara S J. Pediatr. 2016 Jun
Intercenter Cost Variation for Perinatal Hypoxic-Ischemic Encephalopathy in the Era of Therapeutic Hypothermia.
Massaro AN, Murthy K, Zaniletti I, Cook N, DiGeronimo R, Dizon ML, Hamrick SE, McKay VJ, Natarajan G, Rao R, Richardson T, Smith D, Mathur AM J. Pediatr. 2016 Mar
Chorioamnionitis and Culture-Confirmed, Early-Onset Neonatal Infections.
Wortham JM, Hansen NI, Schrag SJ, Hale E, Van Meurs K, Sánchez PJ, Cantey JB, Faix R, Poindexter B, Goldberg R, Bizzarro M, Frantz I, Das A, Benitz WE, Shane AL, Higgins R, Stoll BJ Pediatrics 2015 Dec
Index of Suspicion in the Nursery: Progressive lethargy in a four-day-old term infant
Weydig HM, Veltkamp D, Kakkilaya V, Stumpf K, Waber LJ, Brion LP NeoReviews 2015 Nov 16 11
The association of congenital heart disease with necrotizing enterocolitis in preterm infants: a birth cohort study.
Motta C, Scott W, Mahony L, Koch J, Wyckoff M, Reisch J, Burchfield PJ, Brion LP J Perinatol 2015 Aug
Index of suspicion. Hyperbilirubinemia without jaundice in a neonate
Sen SK, Mayor R, Engle WD, Blumenschein SD, Brion LP. NeoReviews 2015 Aug 16 8

Books

Featured Books Legend Featured Books

Clinical significance of developmental renal physiology. In Fetal and Neonatal Physiology

Brion LP, Satlin LM (1998). Philadelphia, PA: Saunders.

Kidney and Urinary Tract. In Fanaroff AA, Martin RJ, eds. Neonatal-Perinatal Medicine.

Brion LP, Bernstein J, Spitzer A. (1997). St. Louis, MO: Mosby.

Renal disease. In MacDonald MG, Mullett MD, Seshia MMK. Avery's Neonatology: Pathophysiology and Management of the Newborn.

Nafday S, Brion LP, Benchimol C, Satlin LM, Flynn J, Edelmann CM Jr. (2004). Philadelphia, PA: JB Lippincott Company.

Renal disease. In MacDonald MG, Mullett MD, Seshia MMK, eds. Avery's Neonatology: Pathophysiology and Management of the Newborn

Nafday SM, Woda CB, Saland JM, Flynn JT, Askenzi D, Benchimol C, Brion LP. (2015). Philadelphia, PA: JB Lippincott Company.

Neonatal Jaundice. In Campbell DE, ed. Neonatology for Primary Care.

Kapadia VS, Brion LP. (2015). Elk Grove Village, IL: American Academy of Pediatrics.

Neonatal jaundice in the term and near term infant. In TK McInerny, HM Adam, DE Campbell, DM Kamat, KJ Kelleher, eds. American Academy of Pediatrics Textbook of Pediatric Care.

Brion LP. (2009). Elk Grove Village, IL: American Academy of Pediatrics.

Renal Disease. In MacDonald MG, ed. Neonatology: Pathophysiology and Management of the Newborn.

Brion LP, Satlin LM, Edelmann CM Jr. (1999). Philadelphia, PA: JB Lippincott Company.

Neonatal jaundice.. In Campbell DE. Neonatology for Primary Care

Johnson KA, Maple BB, Brion LP. (2019, in press). Elk Grove Village, IL, American Academy of Pediatrics

Neonatal Jaundice. In Neonatology for Primary Care

Johnson KA, Maple BB, Brion LP (2020). Elk Groove Village, IL, American Academy of Pediatrics

Renal disease. In Avery's Neonatology: Pathophysiology and Managementof the Newborn, 8th Edition

Luc P Brion (2020). Philadelphia, JB Lippincott Company

The use of plasma creatinine concentration for estimating glomerular filtration rate in infants, children and adolescents.. In Pediatric Clinics of North America

Schwartz GJ, Brion LP, Spitzer A. (1986). Phildelphia, PA, Elsevier

Carbonic anhydrases in the nervous system. In WR Chegwidden, ND Carter, YH Edwards. The carbonic anhydrases: New Horizons.

Cammer WB, Brion LP (2000). Basel, Switzerland, Birkhäuser Verlag

Honors & Awards

  • Elected to American Pediatric Society
    (2015)
  • ‘Individualizing and Optimizing Nutrition to Prevent Metabolic Syndrome and To Improve Neurodevelopment in Preterm and Small for Gestational Age Infants’
    Gerber Foundation, National Grant (2015-2019)
  • ‘Optimizing Individual Nutrition in Preterm Very Low Birth Weight Infants’
    Children’s Medical Center Clinical Advisory Committee (CCRAC) – Senior Investigator Research Award New Direction (2015-2017)
  • Site Alternate PI, UTSW, Dallas
    National Institute of Child Health and Human Development Eunice Kennedy Shriver Cooperative Multicenter Neonatal Research Network: (2011-2021)
  • Recognition by program directors for special contribution
    COGME, Albert Einstein College of Medicine, Bronx, NY (2006)
  • Listed in Top Doctors
    American Registry (2004-2005)
  • Best Doctors in America
    (2003-2014)
  • America's Registry of Outstanding Professionals
    (2002-2003)
  • Listed
    America’s Registry of Outstanding Professionals (2002-2003)
  • Listed in “Guide to America’s Pediatricians”
    Consumer’s Research Council of America (2002-2003)
  • Listed
    Strathmore’s Who’s Who (2001-2003)
  • New York Metro Area Top Doctors
    Castle Connolly Medical Ltd (2001-2005)
  • Listed in 3rd & 4th Eds, How to Find the Best Doctors: New York Metro Area
    Castle Connolly Guide (1998-1999)
  • Listed in ‘The Best Doctors in New York,’ Neonatal-Perinatal Medicine,
    New York Magazine (1998-2002)
  • Grant-in-Aid: ‘Regulation of renal membrane-bound carbonic anhydrase in response to acidosis’
    American Heart Association (1997-1999)
  • ‘Hormonal and cellular mechanisms of failure to thrive in acidotic mice’
    Pharmacia Inc (1997-1999)
  • Hormonal mechanisms of growth failure in chronic acidosis
    Pharmacia (1996-1997)
  • ‘Hormonal mechanisms of growth failure in chronic acidosis’
    Genentech Foundation for Growth and Development (1996-1998)
  • Interdivisional Research Award (IRA), ‘Role of somatotropin in growth retardation associated with chronic metabolic acidosis’
    Department of Pediatrics, Montefiore Medical Center (1995-1997)
  • “Molecular regulation of carbonic anhydrase IV isozymes’
    Department of Pediatrics Internal Grant, Montefiore Medical Center (1995-1997)
  • Biomedical Research Grants & Crisis Support Grant
    Albert Einstein College of Medicine (1990-1996)
  • Clinical Investigator Award: 'Regulation and development of renal acid-base transport'
    NIDDK (1990-1995)
  • Scholarship Award in Pediatrics
    Université Libre de Bruxelles, Brussels, Belgium (1976-1977)
  • Prix Fleurice Mercier
    Université Libre de Bruxelles (1970-1971)

Professional Associations/Affiliations

  • American Pediatric Society (2014)
  • American Academy of Pediatrics
  • American Medical Association
  • Society of Pediatric Research