Biography

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Dr. Luc P Brion has published more than 170 manuscripts and 12 chapters and presented more than 110 abstracts. During his training in pediatrics and in neonatology, he participated and conducted studies on growth, nutrition and assessment of renal function in neonates and children. As Faculty at the Albert Einstein College of Medicine in New York (AECOM), he was funded for years by the NIH, American Heart Association, Genentech Foundation, and Pharmacia for basic sciences research in developmental nephrology, specifically renal acid secretion, carbonic anhydrase, pathophysiological effects of acidosis and growth. Dr. Brion has served on the IRB at AECOM. Dr. Brion was Director of the Fellowship Training Program in Neonatal-Perinatal Medicine at AECOM in 1997-2006. 

Dr. Brion was Director of the Fellowship Training Program in Neonatal-Perinatal Medicine at UTSW in 2007-2019. He has been research mentor for more than 30 trainees. He is a member of the Neonatal Review Group of the Cochrane Collaboration. He has participated in 5 randomized controlled trials (RCTs) in preterm infants and several multi-center research studies. Since 2009, he has been the University of Texas Southwestern (UTSW) Alternate PI for the NICHD Eunice Kennedy Shriver Cooperative Multicenter Neonatal Research Network (NRN). Dr. Brion serves on the subcommittee on protection of human subjects of the NRN. 

Dr. Brion's current research interest includes (1) improving nutrition and growth in very preterm and very low birth weight infants to optimize neurodevelopment and to reduce signs suggestive of metabolic syndrome in high-risk preterm infants and (2) using evidence-based medicine to improve morbidity and morbidity in neonates. He has obtained funding from Children’s Medical Center Foundation at Dallas and from the Gerber Foundation.

In preterm infants fed human milk, milk fortification can be adjusted by 1) optimization, based on growth rate and serum analyses, or 2) individualization, based on daily human milk nutrient analysis. Randomized allocation to adjusting macronutrients based on breast milk analysis in preterm neonates did not improve weight gain, linear growth or weight/length disproportion at 36 weeks postmentrual age or discharge. Long-term follow-up of these infants is now in process to assess the development of signs of metabolic syndrome and neurodevelopment. 

Valid serial length measurements in preterm infants were shown to permit characterization of growth patterns. A quality improvement project using adjustable feedings plus accurate serial length measurements was successful in reducing excessive weight gain and weight length disproportion at discharge without affecting linear growth, head growth or neurodevelopment. Among extremely low gestational age neonates (ELGANs) a serum Zinc concentration was obtained in 52 with insufficient linear growth (17%). Zinc deficiency was diagnosed in 33% small for GA (SGA) compared to 13% non-SGA infants (P=0.01). Zinc supplementation for >2 weeks improved head growth to discharge or 50 weeks postmenstrual age in infants with Zinc deficiency. 

A quality improvement project is in progress at Parkland Hospital, aiming at reducing necrotizing enterocolitis stage II or greater (Bell classification) among high-risk neonates, i.e., those born with gestational age < 33 weeks and those with birthweight < 1500 grams.

In 2013 Dr. Brion took the Clinical Safety and Efficacy Course at UTSW. He supervises a team of research nurses who maintain the Divisional extensive neonatal intensive care unit (NICU) clinical databases at Parkland and Children’s Medical Center and databases for the Vermont Oxford Neonatal Network (VON) and Children’s Hospital Network Database (CHND). He compiles and presents an Annual Report of mortality and morbidity of neonates admitted to Parkland NICU and compares them to those of the NICHD NRN, VON and national data. He has used the databases for quality improvement and for research.

Education

Medical School
Universite Libre de Bruxelles (1976)
Residency
Hopital Universitaire Saint-Pierre (1979), Pediatrics
Residency
Institut Edith Cavell (1981), Pediatrics
Fellowship
Hospital for Sick Children (1982), Neonatal-perinatal Medicine
Fellowship
Institut Edith Cavell (1982), Neonatal-perinatal Medicine
Fellowship
Cliniques Universitaires (1983), Neonatal-perinatal Medicine
Fellowship
Albert Einstein College of Medicine/Montefiore Medical Center (1985), Neonatal-perinatal Medicine
Residency
Montefiore Medical Center/ Albert Einstein College of Medicine (1986), Pediatrics

Research Interest

  • Neonatal mortality/morbidity
  • Neonatal nutrition and gorwth
  • Renal disease

Publications

Featured Publications LegendFeatured Publications

Surgery-Associated Infections among Infants Born Prematurely.
Shane AL, Hansen NI, Moallem M, Wyckoff MH, Sánchez PJ, Stoll BJ, J Pediatr 2021 Aug
Venovenous versus venoarterial extracorporeal membrane oxygenation among infants with hypoxic-ischemic encephalopathy: is there a difference in outcome?
Agarwal P, Natarajan G, Sullivan K, Rao R, Rintoul N, Zaniletti I, Keene S, Mietzsch U, Massaro AN, Billimoria Z, Dirnberger D, Hamrick S, Seabrook RB, Weems MF, Cleary JP, Gray BW, DiGeronimo R, J Perinatol 2021 May
Correction: Role of zinc in neonatal growth and brain growth: review and scoping review.
Brion LP, Heyne R, Lair CS, Pediatr Res 2021 Mar
Neurodevelopmental outcome of preterm infants enrolled in myo-inositol randomized controlled trial.
Adams-Chapman I, Watterberg KL, Nolen TL, Hirsch S, Cole CA, Cotten CM, Oh W, Poindexter BB, Zaterka-Baxter KM, Das A, Lacy CB, Scorsone AM, Duncan AF, DeMauro SB, Goldstein RF, Colaizy TT, Wilson-Costello DE, Purdy IB, Hintz SR, Heyne RJ, Myers GJ, Fuller J, Merhar S, Harmon HM, Peralta-Carcelen M, Kilbride HW, Maitre NL, Vohr BR, Natarajan G, Mintz-Hittner H, Quinn GE, Wallace DK, Olson RJ, Orge FH, Tsui I, Gaynon M, Hutchinson AK, He YG, Winter TW, Yang MB, Haider KM, Cogen MS, Hug D, Bremer DL, Donahue JP, Lucas WR, Phelps DL, Higgins RD, J Perinatol 2021 Mar
Umbilical Cord Milking versus Delayed Cord Clamping and Associations with In-Hospital Outcomes among Extremely Premature Infants.
Kumbhat N, Eggleston B, Davis AS, DeMauro SB, Van Meurs KP, Foglia EE, Lakshminrusimha S, Walsh MC, Watterberg KL, Wyckoff MH, Das A, Handley SC, J Pediatr 2021 Jan
Transient hypoglycemia and test performance in at-risk newborns.
ElHassan NO, Shaefer EW, Gonzalez B, Nienaber T, Brion LP, Kaiser JR. Am J Perinatology 2021
Association of High Screen-Time Use With School-age Cognitive, Executive Function, and Behavior Outcomes in Extremely Preterm Children
Vohr BR, McGowan EC, Bann C, Das A, Higgins R, Hintz S; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. (Brion et al) JAMA Pediatr . 2021 Online ahead of print. PMID: 34251406
Association of antenatal steroids with neonatal mortality and morbidity in preterm infants born to mothers with diabetes mellitus and hypertension.
Weydig HM, Rosenfeld CR, Jaleel MA, Burchfield PJ, Frost MS, Brion LP. J Perinatol 2021 May 25 doi: 10.1038/s41372-021-01090-x. Online ahead of print. PMID: 34035455
Quality Improvement Project Designed to Reduce Disproportionate Growth in Extremely Low Gestational Age Neonates: Cognitive Neurodevelopmental Outcome at 18-41 Months
Jordan Reis, Kristine Tolentino-Plata, Roy Heyne, Larry Brown, Charles Rosenfeld, Maria Caraig, Patti Burchfield, and Luc Brion J Perinatol 2021
Re: Zinc Levels inre: Neonatal Life Influence Long-Term Neurodevelopment.
Brion LP, Heyne R, Lair CS. J Perinatol 2021

Books

Featured Books Legend Featured Books

Clinical significance of developmental renal physiology. In RA Polin, WW Fox; Fetal and Neonatal Physiology

Brion LP, Satlin LM (1998). Philadelphia, PA, Philadelphia, PA: Saunders.

Kidney and Urinary Tract. In Fanaroff AA, Martin RJ, eds. Neonatal-Perinatal Medicine.

Brion LP, Bernstein J, Spitzer A. (1997). St. Louis, MO: Mosby.

Renal disease. In MacDonald MG, Mullett MD, Seshia MMK. Avery's Neonatology: Pathophysiology and Management of the Newborn.

Nafday S, Brion LP, Benchimol C, Satlin LM, Flynn J, Edelmann CM Jr. (2004). Philadelphia, PA: JB Lippincott Company.

Renal disease. In MacDonald MG, Mullett MD, Seshia MMK, eds. Avery's Neonatology: Pathophysiology and Management of the Newborn

Nafday SM, Woda CB, Saland JM, Flynn JT, Askenzi D, Benchimol C, Brion LP. (2015). Philadelphia, PA: JB Lippincott Company.

Neonatal Jaundice. In Campbell DE, ed. Neonatology for Primary Care.

Kapadia VS, Brion LP. (2014). Elk Grove Village, IL: American Academy of Pediatrics.

Neonatal jaundice in the term and near term infant. In TK McInerny, HM Adam, DE Campbell, DM Kamat, KJ Kelleher, eds. American Academy of Pediatrics Textbook of Pediatric Care.

Brion LP. (2009). Elk Grove Village, IL: American Academy of Pediatrics.

Renal Disease. In MacDonald MG, ed. Neonatology: Pathophysiology and Management of the Newborn.

Brion LP, Satlin LM, Edelmann CM Jr. (1999). Philadelphia, PA: JB Lippincott Company.

Neonatal jaundice.. In Campbell DE. Neonatology for Primary Care

Johnson KA, Maple BB, Brion LP. (2019, in press). Elk Grove Village, IL, American Academy of Pediatrics

Renal disease.. In MacDonald MG, Mullett MD, Seshia MMK. Avery's Neonatology: Pathophysiology and Management of the Newborn.

Nafday SM, Woda CB, Saland JM, Flynn JT, Askenazi D, Benchimol C, Brion (2021). Philadelphia., JB Lippincott Company,

Neonatal Jaundice. In Campbell DE, ed: Neonatology for Primary Care

Johnson KA, Maple BB, Brion LP (2020). Elk Groove Village, IL, American Academy of Pediatrics

Neonatal jaundice. In McInerny T, Adam HM, Campbell DE, Foy JM, Kamat, DM, and DeWitt TG, eds. AAP Textbook of Pediatric Care

Kapadia VS, Brion LP (2015). Elk Grove Village, IL, McInerny T, Adam HM, Campbell DE, Foy JM, Kamat, DM, and DeWitt TG. American Academy of Pediatrics.

The use of plasma creatinine concentration for estimating glomerular filtration rate in infants, children and adolescents.. In Pediatric Clinics of North America

Schwartz GJ, Brion LP, Spitzer A. (1986). Phildelphia, PA, Elsevier

Carbonic anhydrases in the nervous system. In WR Chegwidden, ND Carter, YH Edwards. The carbonic anhydrases: New Horizons.

Cammer WB, Brion LP (2000). Basel, Switzerland, Birkhäuser Verlag

Honors & Awards

  • Provider of the Month, Children’s Medical Center of Dallas, NICU, May 2019
    (2019)
  • Elected to American Pediatric Society
    (2015)
  • ‘Individualizing and Optimizing Nutrition to Prevent Metabolic Syndrome and To Improve Neurodevelopment in Preterm and Small for Gestational Age Infants’
    Gerber Foundation, National Grant (2015-2019)
  • ‘Optimizing Individual Nutrition in Preterm Very Low Birth Weight Infants’
    Children’s Medical Center Clinical Advisory Committee (CCRAC) – Senior Investigator Research Award New Direction (2015-2017)
  • Site Alternate PI, UTSW, Dallas
    National Institute of Child Health and Human Development Eunice Kennedy Shriver Cooperative Multicenter Neonatal Research Network: (2011-2021)
  • Recognition by program directors for special contribution
    COGME, Albert Einstein College of Medicine, Bronx, NY (2006)
  • Listed in Top Doctors
    American Registry (2004-2005)
  • Best Doctors in America
    (2003-2014)
  • America's Registry of Outstanding Professionals
    (2002-2003)
  • Listed
    America’s Registry of Outstanding Professionals (2002-2003)
  • Listed in “Guide to America’s Pediatricians”
    Consumer’s Research Council of America (2002-2003)
  • Listed
    Strathmore’s Who’s Who (2001-2003)
  • New York Metro Area Top Doctors
    Castle Connolly Medical Ltd (2001-2005)
  • Listed in 3rd & 4th Eds, How to Find the Best Doctors: New York Metro Area
    Castle Connolly Guide (1998-1999)
  • Listed in ‘The Best Doctors in New York,’ Neonatal-Perinatal Medicine,
    New York Magazine (1998-2002)
  • Grant-in-Aid: ‘Regulation of renal membrane-bound carbonic anhydrase in response to acidosis’
    American Heart Association (1997-1999)
  • ‘Hormonal and cellular mechanisms of failure to thrive in acidotic mice’
    Pharmacia Inc (1997-1999)
  • Hormonal mechanisms of growth failure in chronic acidosis
    Pharmacia (1996-1997)
  • ‘Hormonal mechanisms of growth failure in chronic acidosis’
    Genentech Foundation for Growth and Development (1996-1998)
  • Interdivisional Research Award (IRA), ‘Role of somatotropin in growth retardation associated with chronic metabolic acidosis’
    Department of Pediatrics, Montefiore Medical Center (1995-1997)
  • “Molecular regulation of carbonic anhydrase IV isozymes’
    Department of Pediatrics Internal Grant, Montefiore Medical Center (1995-1997)
  • Biomedical Research Grants & Crisis Support Grant
    Albert Einstein College of Medicine (1990-1996)
  • Clinical Investigator Award: 'Regulation and development of renal acid-base transport'
    NIDDK (1990-1995)
  • Scholarship Award in Pediatrics
    Université Libre de Bruxelles, Brussels, Belgium (1976-1977)
  • Prix Fleurice Mercier
    Université Libre de Bruxelles (1970-1971)

Professional Associations/Affiliations

  • American Pediatric Society (2014)
  • Cochrane Collaboration (1999)
  • Society of Pediatric Research (1992)
  • American Academy of Pediatrics (1987)
  • American Medical Association