Luc “Luc P Brion” Brion, M.D. Professor Emeritus School Medical School Department Pediatrics Graduate Programs Organic Chemistry You have reached the Academic Profile. For more information on the doctor and patient care, please visit the clinical profile. Biography Download Curriculum Vitae Dr. Luc P Brion has published more than 170 manuscripts and 12 chapters and presented more than 110 abstracts. During his training in pediatrics and in neonatology, he participated and conducted studies on growth, nutrition and assessment of renal function in neonates and children. As Faculty at the Albert Einstein College of Medicine in New York (AECOM), he was funded for years by the NIH, American Heart Association, Genentech Foundation, and Pharmacia for basic sciences research in developmental nephrology, specifically renal acid secretion, carbonic anhydrase, pathophysiological effects of acidosis and growth. Dr. Brion has served on the IRB at AECOM. Dr. Brion was Director of the Fellowship Training Program in Neonatal-Perinatal Medicine at AECOM in 1997-2006. Dr. Brion was Director of the Fellowship Training Program in Neonatal-Perinatal Medicine at UTSW in 2007-2019. He has been research mentor for more than 30 trainees. He is a member of the Neonatal Review Group of the Cochrane Collaboration. He has participated in 5 randomized controlled trials (RCTs) in preterm infants and several multi-center research studies. From 2009 until 2023 he was the University of Texas Southwestern (UTSW) Alternate PI for the NICHD Eunice Kennedy Shriver Cooperative Multicenter Neonatal Research Network (NRN). Dr. Brion served on the subcommittee on protection of human subjects of the NRN. Dr. Brion's current research interest includes (1) improving nutrition and growth in very preterm and very low birth weight infants to optimize neurodevelopment and to reduce signs suggestive of metabolic syndrome in high-risk preterm infants and (2) using evidence-based medicine to improve morbidity and morbidity in neonates. In preterm infants fed human milk, milk fortification can be adjusted by 1) optimization, based on growth rate and serum analyses, or 2) individualization, based on daily human milk nutrient analysis. Randomized allocation to adjusting macronutrients based on breast milk analysis in preterm neonates did not improve weight gain, linear growth or weight/length disproportion at 36 weeks postmentrual age or discharge. Follow-up at 18-38 months showed that the type of feeding supplementation had no effect on Bayley scores. At 3 years of age, infants in the experimental arm (individualized fortification) had central obesity and higher serum leptin:adiponectin ratio and central obesity compared with controls. Notably, serum leptin:adiponectin ratio was strongly correlated with weight gain and anthropometric measurements suggesting central obesity. Valid serial length measurements in preterm infants were shown to permit characterization of growth patterns. A quality improvement project using adjustable feedings plus accurate serial length measurements was successful in reducing excessive weight gain and weight length disproportion at discharge without affecting linear growth, head growth or neurodevelopment. Among extremely low gestational age neonates (ELGANs) a serum Zinc concentration was obtained in 52 with insufficient linear growth (17%). Zinc supplementation for >2 weeks improved head growth to discharge or 50 weeks postmenstrual age in infants with Zinc deficiency. Additional studies are in process to assess linear growth, ventricular size and neurodevelopment. A quality improvement project is in progress at Parkland Hospital, aiming at reducing necrotizing enterocolitis stage II or greater (Bell classification) among high-risk neonates, i.e., those born with gestational age < 33 weeks and those with birthweight < 1500 grams. Another project is designed to assess risk for either death or developing necrotizing enterocolitis stage III. In 2013 Dr. Brion took the Clinical Safety and Efficacy Course at UTSW. He supervises a team of research nurses who maintain the Divisional extensive neonatal intensive care unit (NICU) clinical databases at Parkland and Children’s Medical Center and databases for the Vermont Oxford Neonatal Network (VON) and Children’s Hospital Network Database (CHND). He compiled and presented an Annual Report of mortality and morbidity of neonates admitted to Parkland NICU and compared them to those of the NICHD NRN, VON and national data. He has used the databases for quality improvement and for research. Dr. Brion retired on April 10, 2023 and is now professor emeritus. Education Medical School Universite Libre de Bruxelles (1976) Residency Hopital Universitaire Saint-Pierre (1979), Pediatrics Residency Institut Edith Cavell (1981), Pediatrics Fellowship Hospital for Sick Children (1982), Neonatal-perinatal Medicine Fellowship Institut Edith Cavell (1982), Neonatal-perinatal Medicine Fellowship Cliniques Universitaires (1983), Neonatal-perinatal Medicine Fellowship Albert Einstein College of Medicine/Montefiore Medical Center (1985), Neonatal-perinatal Medicine Residency Montefiore Medical Center/ Albert Einstein College of Medicine (1986), Pediatrics Research Interest Necrotizing enterocolitis Neonatal mortality/morbidity Neonatal nutrition and gorwth Renal disease Publications Featured Publications Multivariate Analysis of Factors Associated with Feeding Mother's Own Milk at Discharge in Preterm Infants: A Retrospective Cohort Study. Reis JD, Sánchez-Rosado M, Mathai D, Kiefaber I, Brown LS, Lair CS, Nelson DB, Burchfield P, Brion LP, Am J Perinatol 2024 Jul Maternal and neonatal outcomes associated with illness severity of maternal COVID-19. Sisman J, Adhikari EH, Black LF, Weiss A, Brown LS, Brion LP, J Neonatal Perinatal Med 2024 May Social Determinants of Health and Redirection of Care for Infants Born Extremely Preterm. Brumbaugh JE, Bann CM, Bell EF, Travers CP, Vohr BR, McGowan EC, Harmon HM, Carlo WA, Hintz SR, Duncan AF, JAMA Pediatr 2024 Mar Social distancing and extremely preterm births in the initial COVID-19 pandemic period. Shukla VV, Carper BA, Ambalavanan N, Rysavy MA, Bell EF, Das A, Patel RM, D'Angio CT, Watterberg KL, Cotten CM, Merhar SL, Wyckoff MH, Sánchez PJ, Kumbhat N, Carlo WA, J Perinatol 2024 Feb Association of maternal pre-pregnancy or first trimester body mass index with neurodevelopmental impairment or death in extremely low gestational age neonates. Chawla S, Laptook AR, Smith EA, Tan S, Natarajan G, Wyckoff MH, Greenberg RG, Ambalavanan N, Bell EF, Van Meurs KP, Hintz SR, Vohr BR, Werner EF, Das A, Shankaran S, J Perinatol 2024 Feb Neurodevelopmental Outcomes of Extremely Preterm Infants Fed Donor Milk or Preterm Infant Formula: A Randomized Clinical Trial. Colaizy TT, Poindexter BB, McDonald SA, Bell EF, Carlo WA, Carlson SJ, DeMauro SB, Kennedy KA, Nelin LD, Sánchez PJ, Vohr BR, Johnson KJ, Herron DE, Das A, Crawford MM, Walsh MC, Higgins RD, Stoll BJ, Ambalavanan N, Wyckoff MH, D'Angio CT, Bugg GW, Ohls RK, Reynolds AM, Sokol GM, Laptook AR, Olsen SL, White JR, Jadcherla SR, Bajaj M, Parimi PS, Schmidt B, Laughon MM, Barks J, Fisher KA, Hibbs AM, Peralta-Carcelen M, Cook N, Heyne RJ, Cavanaugh B, Adams-Chapman I, Fuller J, Hartley-McAndrew ME, Harmon HM, Duncan AF, Hines AC, Kilbride HW, Richards LA, Maitre NL, Natarajan G, Trembath AN, Carlson MD, Malcolm WF, Wilson-Costello DE, JAMA 2024 Feb 331 7 582-591 Optimal Delivery Management for the Prevention of Early Neonatal SARS-CoV-2 Infection: Systematic review and Meta-analysis. Chan C, Kong JY, Sultana R, Mundra V, Babata K, Mazzarella K, Adhikari EH, Yeo KT, Hascoet JM, Brion L, Am J Perinatol 2024 Jan Development of a prediction model for surgery or early mortality at the time of initial assessment for necrotizing enterocolitis. Nayak SP, Sanchez-Rosado M, Reis JD, Brown LS, Mangona KL, Sharma P, Nelson DB, Wyckoff MH, Pandya S, Mir IN, Brion L, Am J Perinatol 2024 Jan Maternal body mass index and necrotizing enterocolitis: A case-control study. Stumpf K, Sharma P, Brown LS, Brion LP, Mirpuri J, PLoS One 2024 19 1 e0296644 Impact of fetal inflammatory response on the severity of necrotizing enterocolitis in preterm infants. Mir IN, Sánchez-Rosado M, Reis J, Uddin N, Brown LS, Mangona KL, Nelson D, Wyckoff M, Nayak SP, Brion L, Pediatr Res 2023 Dec Results 1-10 of 216 1 2 3 4 5 Next Last Books Featured Books Renal Disease. In Neonatology: Pathophysiology and Management of the Newborn. JB Lippincott Company, Philadelphia. Fourth Edition, MacDonald MG (1994). Philadelphia, JB Lippincott Company Clinical significance of developmental renal physiology. In RA Polin, WW Fox; Fetal and Neonatal Physiology Brion LP, Satlin LM (1998). Philadelphia, PA, Philadelphia, PA: Saunders. Kidney and Urinary Tract. In Fanaroff AA, Martin RJ, eds. Neonatal-Perinatal Medicine. Brion LP, Bernstein J, Spitzer A. (1997). St. Louis, MO: Mosby. Renal disease. In MacDonald MG, Mullett MD, Seshia MMK. Avery's Neonatology: Pathophysiology and Management of the Newborn.. 6th edition Nafday S, Brion LP, Benchimol C, Satlin LM, Flynn J, Edelmann CM Jr. (2005). Philadelphia, PA: JB Lippincott Company. Renal disease. In MacDonald MG, Mullett MD, Seshia MMK, eds. Avery's Neonatology: Pathophysiology and Management of the Newborn. 7th edition Nafday SM, Woda CB, Saland JM, Flynn JT, Askenzi D, Benchimol C, Brion LP. (2016). Philadelphia, PA: JB Lippincott Company. Neonatal Jaundice. In Campbell DE, ed. Neonatology for Primary Care. Kapadia VS, Brion LP. (2014). Elk Grove Village, IL: American Academy of Pediatrics. Neonatal jaundice in the term and near term infant. In TK McInerny, HM Adam, DE Campbell, DM Kamat, KJ Kelleher, eds. American Academy of Pediatrics Textbook of Pediatric Care. Brion LP. (2008). Elk Grove Village, IL: American Academy of Pediatrics. Renal Disease. In MacDonald MG, ed. Neonatology: Pathophysiology and Management of the Newborn.. 5th edition Brion LP, Satlin LM, Edelmann CM Jr. (1999). Philadelphia, PA: JB Lippincott Company. Neonatal jaundice.. In Campbell DE. Neonatology for Primary Care Johnson KA, Maple BB, Brion LP. (2020). Elk Grove Village, IL, American Academy of Pediatrics Renal disease.. In MacDonald MG, Mullett MD, Seshia MMK. Avery's Neonatology: Pathophysiology and Management of the Newborn. Nafday SM, Woda CB, Saland JM, Flynn JT, Askenazi D, Benchimol C, Brion (2021). Philadelphia., JB Lippincott Company, Neonatal jaundice. In McInerny T, Adam HM, Campbell DE, Foy JM, Kamat, DM, and DeWitt TG, eds. AAP Textbook of Pediatric Care Kapadia VS, Brion LP (2015). Elk Grove Village, IL, McInerny T, Adam HM, Campbell DE, Foy JM, Kamat, DM, and DeWitt TG. American Academy of Pediatrics. The use of plasma creatinine concentration for estimating glomerular filtration rate in infants, children and adolescents.. In Pediatric Clinics of North America Schwartz GJ, Brion LP, Spitzer A. (1986). Phildelphia, PA, Elsevier Carbonic anhydrases in the nervous system. In WR Chegwidden, ND Carter, YH Edwards. The carbonic anhydrases: New Horizons. Cammer WB, Brion LP (2000). Basel, Switzerland, Birkhäuser Verlag Honors & Awards Provider of the Month, Childrens Medical Center of Dallas, NICU, May 2019 (2019) Elected to American Pediatric Society (2015) Individualizing and Optimizing Nutrition to Prevent Metabolic Syndrome and To Improve Neurodevelopment in Preterm and Small for Gestational Age InfantsGerber Foundation, National Grant (2015-2019) Optimizing Individual Nutrition in Preterm Very Low Birth Weight InfantsChildrens Medical Center Clinical Advisory Committee (CCRAC) Senior Investigator Research Award New Direction (2015-2017) Site Alternate PI, UTSW, DallasNational Institute of Child Health and Human Development Eunice Kennedy Shriver Cooperative Multicenter Neonatal Research Network: (2011-2021) Recognition by program directors for special contributionCOGME, Albert Einstein College of Medicine, Bronx, NY (2006) Listed in Top DoctorsAmerican Registry (2004-2005) Best Doctors in America (2003-2014) America's Registry of Outstanding Professionals (2002-2003) ListedAmericas Registry of Outstanding Professionals (2002-2003) Listed in Guide to Americas PediatriciansConsumers Research Council of America (2002-2003) ListedStrathmores Whos Who (2001-2003) New York Metro Area Top DoctorsCastle Connolly Medical Ltd (2001-2005) Listed in 3rd & 4th Eds, How to Find the Best Doctors: New York Metro AreaCastle Connolly Guide (1998-1999) Listed in The Best Doctors in New York, Neonatal-Perinatal Medicine,New York Magazine (1998-2002) Grant-in-Aid: Regulation of renal membrane-bound carbonic anhydrase in response to acidosisAmerican Heart Association (1997-1999) Hormonal and cellular mechanisms of failure to thrive in acidotic micePharmacia Inc (1997-1999) Hormonal mechanisms of growth failure in chronic acidosisPharmacia (1996-1997) Hormonal mechanisms of growth failure in chronic acidosisGenentech Foundation for Growth and Development (1996-1998) Interdivisional Research Award (IRA), Role of somatotropin in growth retardation associated with chronic metabolic acidosisDepartment of Pediatrics, Montefiore Medical Center (1995-1997) Molecular regulation of carbonic anhydrase IV isozymesDepartment of Pediatrics Internal Grant, Montefiore Medical Center (1995-1997) Biomedical Research Grants & Crisis Support GrantAlbert Einstein College of Medicine (1990-1996) Clinical Investigator Award: 'Regulation and development of renal acid-base transport'NIDDK (1990-1995) Scholarship Award in PediatricsUniversité Libre de Bruxelles, Brussels, Belgium (1976-1977) Special Bachelor's Degree in PediatricsUniversité Libre de Bruxelles, Brussels, Belgium (1976-1981) Special Bachelor's Degree in PediatricsUniversité Libre de Bruxelles, Brussels, Belgium (1976-1981) Prix Fleurice MercierUniversité Libre de Bruxelles (1970-1971) Professional Associations/Affiliations American Academy of Pediatrics (1987) American Medical Association American Pediatric Society (2014) Cochrane Collaboration (1999) Society of Pediatric Research (1992)
