Biography

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Juan M. Pascual, MD, PhD is the inaugural holder of The Once Upon a Time Foundation Professorship in Pediatric Neurologic Diseases and the holder of the Ed and Sue Rose Distinguished Professorship in Neurology.

Dr. Pascual provides both pediatric and adult neurology care. Adults should contact the Neurology Clinic at James. W. Aston Ambulatory Care Center at 214-645-8800 to make an appointment. For pediatric appointments, please contact Children’s Medical Center using the online scheduling form, or by calling 214-456-2768.

Dr. Pascual is a tenured Professor in four Departments at The University of Texas Southwestern Medical Center at Dallas: Neurology and Neurotherapeutics, Physiology, Pediatrics and the Eugene McDermott Center for Human Growth & Development / Center for Human Genetics, and is Director of the Rare Brain Disorders Program (Clinic and Laboratory). He is also a member of the Division of Pediatric Neurology, of the graduate Ph.D. programs in Neuroscience and Integrative Biology, and of the postgraduate clinical training programs in Neurology, Pediatric Neurology, Pediatrics and Medical Genetics. He also teaches at the UT Southwestern Medical School.

In addition, Dr. Pascual is an adjunct professor in the Department of Biological Sciences at the School of Natural Sciences and Mathematics, The University of Texas at Dallas.

Dr. Pascual directs a highly collaborative research laboratory and is credentialed campus-wide at Children's Medical Center Dallas, UT Southwestern University Hospitals and Clinics and Parkland Memorial Hospital, where he consults on inpatients and outpatients with particularly complex or severe diseases. Much of his research is funded by the National Institutes of Health.

His laboratory research interests span virtually the entire field of neuroscience, including medical neuroscience, from molecular structure and function (including drug action), neural physiology and metabolism at the cellular, circuit and whole-brain level and neurogenetics, all of which is complemented with neurological patient care and clinical trials. Laboratory research greatly influences his clinical activities and patient observations guide his laboratory research direction.

Dr. Pascual received his M.D. degree with unique distinction from the Universidad de Granada, Spain, one of the oldest universities in the world, founded in 1349 by Yusuf I, Sultan of Granada and one of the builders of the Alhambra. He received his Ph.D. degree in Molecular Physiology and Biophysics from Baylor College of Medicine in Houston, Texas, under Arthur M. Brown, MD, PhD, McCollum Professor and Chair. His postdoctoral research was conducted under Arthur Karlin, PhD, Higgins Professor and Director of the Center for Molecular Recognition, College of Physicians and Surgeons of Columbia University and, later, at the Colleen Giblin Research Laboratories for Pediatric Neurology at the same institution under a Neurological Sciences Academic Development Award from the National Institute of Neurological Disorders and Stroke. He also received residency training in Pediatrics at Washington University School of Medicine - St. Louis Children’s Hospital and in Neurology and Pediatric Neurology at the Neurological Institute of New York - Columbia University Medical Center. He received certification in Neurology with Special Qualification in Child Neurology from the American Board of Psychiatry and Neurology.

As one of few actively practising pediatric neurologists in the nation who is also a laboratory scientist, Dr. Pascual is interested in the molecular mechanisms that cause inherited metabolic and excitability disorders using electrophysiology and nuclear magnetic resonance (MRI) both in human subjects and in models of human diseases. His laboratory is located in the newest biomedical research building (NL) at UT Southwestern and is an integral part of the Department of Neurology and Neurotherapeutics. The laboratory is home to scientists from very broad backgrounds and levels of training and expertise who have joined efforts to endow both pediatric neurology and human developmental neuroscience with a strong scientific basis.

As a clinician, Dr. Pascual specializes in genetic and metabolic diseases of the nervous and neuromuscular systems of infants, children and adults with a particular emphasis on complex diagnostic problems, second opinions for patients visiting from the rest of the U.S. and abroad, and in clinical trials. Dr. Pascual has special clinical research expertise in rare diseases, glucose metabolism, mitochondrial, degenerative, and multi-organ disorders. 

Dr. Pascual has co-authored over two dozen scientific, medical and philosophical textbooks. He is the editor, together with Dr. Roger Rosenberg of Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease (5th edition, 1464 pages, Academic Press, 2015; two-volume 6th edition in press). His textbook Progressive Brain Disorders in Childhood (Cambridge University Press) was published in 2017. He is working on a new book, provisionally entitled Sense & Nonsense in Medical Neuroscience: Inference & Fallacy, to be published by Cambridge University Press.

An avid reader and speaker, Dr. Pascual is also interested in the philosophy of mind. He is particularly concerned with the proper study of the human condition. Thus, he is a critic of errors commonly made by cognitive neuroscientists, which Dr. Peter Hacker has made patent. As a research and clinical neurogeneticist, he has also grown disillusioned with the current simplistic overreliance on genes as an explanation of biology or disease, just as Dr. Denis Noble has argued. Dr. Pascual is a member of the North Texas Bioethics Network.

Dr. Pascual has no interest in - nor is he sponsored by - any for-profit entities that conduct medical research or lobby for financial gain.

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Clinical research studies

Publications listed in PubMed (National Library of Medicine)

Education

Medical School
Universidad de Granada (1990)
Graduate School
Baylor College of Medicine (1995)
Internship
Washington University. St. Louis (1999), Pediatrics
Residency
Columbia Presbyterian Medical Center (2002), Pediatric Neurology

Research Interest

  • 2-hit, multiple-gene and explanatory validity of complex causation models
  • Brain metabolism
  • Clinical trials for neurological and genetic disorders
  • Complex, rare and undiagnosed diseases
  • Final common pathways shared by diseases of neural development
  • Functional brain imaging
  • Human brain development
  • Mitochondrial disorders
  • Neural excitability: synaptic transmission
  • Neurodegenerative diseases of children
  • Neurogenetics
  • Sentience, autonomy and sources of truth
  • Whole exome and genome analyses in neurological disorders

Publications

Featured Publications LegendFeatured Publications

Natural history of MELAS associated with mitochondrial DNA m.3243A>G genotype.
Kaufmann P, Engelstad K, Wei Y, Kulikova R, Oskoui M, Sproule DM, Battista V, Koenigsberger DY, Pascual JM, Shanske S, Sano M, Mao X, Hirano M, Shungu DC, Dimauro S, De Vivo DC Neurology 2011 Nov 77 22 1965-71
Animal models of the human mind: Is there anything it is like to be autistic?
Pascual JM Neuroscience letters 2011 Oct
High-resolution detection of (13)C multiplets from the conscious mouse brain by ex vivo NMR spectroscopy.
Marin-Valencia I, Good LB, Ma Q, Jeffrey FM, Malloy CR, Pascual JM Journal of neuroscience methods 2011 Sep
Cerebral folate deficiency syndromes in childhood: clinical, analytical, and etiologic aspects.
Pérez-Dueñas B, Ormazábal A, Toma C, Torrico B, Cormand B, Serrano M, Sierra C, De Grandis E, Marfa MP, García-Cazorla A, Campistol J, Pascual JM, Artuch R Arch. Neurol. 2011 May 68 5 615-21
Measurement of glycine in the human brain in vivo by (1) H-MRS at 3 T: application in brain tumors.
Choi C, Ganji SK, Deberardinis RJ, Dimitrov IE, Pascual JM, Bachoo R, Mickey BE, Malloy CR, Maher EA Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2011 Mar 609-18
Synaptic transporters are deceived if they think themselves free.
Pascual JM Neurosci. Lett. 2011 Jan 487 1 1-2
Pyruvate carboxylase deficiency: mechanisms, mimics and anaplerosis.
Marin-Valencia I, Roe CR, Pascual JM Mol. Genet. Metab. 2010 Sep 101 1 9-17
Diagnosis and management of Duchenne muscular dystrophy, part 2: implementation of multidisciplinary care.
Bushby K, Finkel R, Birnkrant DJ, Case LE, Clemens PR, Cripe L, Kaul A, Kinnett K, McDonald C, Pandya S, Poysky J, Shapiro F, Tomezsko J, Constantin C Lancet Neurol 2010 Feb 9 2
Diagnosis and management of Duchenne muscular dystrophy, part 1: diagnosis, and pharmacological and psychosocial management.
Bushby K, Finkel R, Birnkrant DJ, Case LE, Clemens PR, Cripe L, Kaul A, Kinnett K, McDonald C, Pandya S, Poysky J, Shapiro F, Tomezsko J, Constantin C Lancet Neurol 2010 Jan 9 1
Childhood chorea with cerebral hypotrophy: a treatable GLUT1 energy failure syndrome.
Pérez-Dueñas B, Prior C, Ma Q, Fernández-Alvarez E, Setoain X, Artuch R, Pascual JM Arch. Neurol. 2009 Nov 66 11 1410-4

Books

Featured Books Legend Featured Books

Floppy infant syndrome. In Merritt's Neurology, 11th and 12th edition

Pascual JM, De Vivo DC (2009). Lippincott, Williams & Wilkins

Pediatric neurology. In On Call Neurology, 2nd and 3rd edition

Pascual JM (2007). W.B. Saunders

Glucose transporter type 1 deficiency syndrome. In Merritt's Neurology, 11th and 12th edition

De Vivo DC, Pascual JM, Wang D (2009). Lippincott, Williams & Wilkins

Disorders of glucose transport. In The Molecular and Genetic Basis of Neurologic and Psychiatric Disease, 3rd and 4th editions

De Vivo DC, Wang D, Pascual JM (2008). LWW

Developmental Neurology: a molecular perspective. In Molecular Neurology, 1st edition

Pascual JM (2007). Academic Press

Metabolic diseases of the nervous system. In Molecular Neurology, 1st edition

Pascual JM (2007). Academic Press

Genetic disorders of neuromuscular development. In Molecular Neurology, 1st edition

Pascual JM (2007). Academic Press

Encephalopathies. In Neurology and Clinical Neuroscience, 1st edition

Pascual JM (2007). Mosby Elsevier

Glucose transporter 1 deficiency syndrome. In National Organization for Rare Disorders' Guide to Rare Disorders

Pascual JM, K. Engelstad, D. Wang, D. C. De Vivo (2002). Lippincott, Williams, and Wilkins

Kernicterus. In Encyclopedia of the Neurological Sciences, 2nd edition

Pascual JM (2014). San Diego, Academic Press

The Can't and Don't of Psychopathy: Neuroimaging Technologies, Psychopaths and Criminal Responsibility. In Neuroethics: Issues at the Intersection of Neuroscience and Society

Jotterand F, Pascual JM, Sadler, JZ (In press). Cambridge University Press

Disorders of Muscle Excitability. In Basic Neurochemistry, 7th and 8th edition

Pascual JM (2011). Elsevier

Disorders of the Krebs cycle and of pyruvate metabolism and transport. In Rudolph's Pediatrics, 22nd edition

Pascual JM, DiMauro S (2011). McGraw-Hill

Pyruvate dehydrogenase, pyruvate carboxylase, Krebs cycle and mitochondrial transport disorders. In Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease, Fifth Edition

Tondo, M; Marin-Valencia, I; Ma, Q; Pascual, JM (2015). San Diego, Academic Press

Menkes disease and other ATP7A disorders. In Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease, Fifth Edition

Pascual, JM; Menkes, JH (2015). San Diego, Academic Press

Wolman disease. In Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease, Fifth Edition

Marin-Valencia, I; Pascual, JM (2015). San Diego, Academic Press

Glucose transporter type I haploinsufficiency. In Movement Disorders, 2nd edition: Genetics and Models

Pascual JM (2014). San Diego, Academic Press

Glucose transporter type I deficiency and other glucose flux disorders. In Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease, Fifth Edition

Pascual, JM; Wang, D; De Vivo, DC (2015). San Diego, Academic Press

Honors & Awards

  • Miembro de honor
    Academia Malagueña de Ciencias (2015)
  • 100% Patient satisfaction
    Division of Pediatric Neurology, Children's Medical Center Dallas (2013)
  • Elected full member
    Académie Européenne des Sciences, des Arts et des Lettres (2013)
  • Research Mentor Award
    Children's Medical Center Dallas (2012)
  • Elected corresponding member
    Académie Européenne des Sciences, des Arts et des Lettres (2010)
  • Miembro correspondiente
    Real Academia de Bellas Artes de San Telmo (2010)
  • Young Investigator Award
    Neurobiology of Disease in Children (2009)
  • Miembro correspondiente
    Real Academia Española (2004)
  • Miembro de número
    Academia Norteamericana de la Lengua Española (2004)

Professional Associations/Affiliations

  • Children's Medical Center Dallas (2007)
  • Parkland Memorial Hospital (2007)
  • UT Southwestern Medical Center Hospitals and Clinics (2007)