Univ of Science & Tech China , Molecular & Cell Biology
Graduate School
Chinese Academy of Sciences-Sh (1995), Biotechnology
Graduate School
Univ of Illinois @ Urbana-Cham (1999), Biochemistry

Research Interest

  • Angiopoietin-like proteins and receptors
  • Cancer, immune checkpoints, stem cells
  • Roles of ITIM-receptors in cancer and immunity


Featured Publications LegendFeatured Publications

Hypoxia and Metabolic Properties of Hematopoietic Stem Cells. Antioxidants & Redox Signaling
Zhang CC, Sadek H. Antioxidants & Redox Signaling. 2014 12 20 epub
Profilin-1 is essential for retention and metabolism of mouse hematopoietic stem cells in bone marrow.
Zheng J, Lu Z, Kocabas F, Bottcher RT, Costell M, Kang X, Liu X, DeBerardinis RJ, Wang Q, Chen G, Sadek H*, Zhang CC*. Blood 2014 123 992-1001
Novel signaling axis in CML-initiating cells.
Zhang CC Blood 2014 16 123
A motif in LILRB2 critical for Angptl2 binding and activation
Deng M*, Lu Z*, Zheng J, Wan X, Chen X, Hirayasu K, Sun H, Lam Y, Chen L, Wang Q, Song C, Huang N, Gao GF, Jiang Y, Arase H, Zhang CC. Blood 2014 epub
Meis1 regulates the metabolic phenotype and oxidative defense of hematopoietic stem cells.
Kocabas F, Zheng J, Thet S, Copeland NG, Jenkins NA, DeBerardinis RJ, Zhang CC*, Sadek HA*. Blood 2012 25 120 4963-72
Angiopoietin-like protein 3 supports the activity of mouse hematopoietic stem cells in the bone marrow niche
Zheng J, Huynh H, Umikawa M, Silvany R, Zhang CC Blood 2011 117 470-479
IGF Binding Protein 2 Supports the Survival and Cycling of Hematopoietic Stem Cells
Huynh H, Zheng J, Umikawa M, Zhang C, Silvany R, Iizuka S, Holzenberger M, Zhang W, Zhang CC Blood 2011 118
IGFBP2 secreted by a tumorigenic cell line supports ex vivo expansion of mouse hematopoietic stem cells
Huynh H, Iizuka S, Kaba M, Kirak O, Zheng J, Lodish HF, Zhang CC Stem Cells 2008 26 1628-1635

Honors & Awards

  • Hortense L. and Morton H. Sanger Professorship in Oncology
  • Leukemia & Lymphoma Society Scholar Award
  • Royan International Research Award
  • Gabrielle’s Angel Foundation for Cancer Research Fellow
  • Basil O’Connor Scholar, March of Dimes Foundation
  • American Society of Hematology Junior Faculty Scholar
  • Howard Temin KO1 Award, National Cancer Institute
  • Michael L. Rosenberg Scholar in Biomedical Research, UT Southwestern Medical Center

Professional Associations/Affiliations

  • American Society for Cell Biology
  • American Society of Hematology
  • International Society for Stem Cell Research