Biography

Download Curriculum Vitae

Dr. Williams received his A.S. degree from Collin County Community College in 1997.  Dr. Williams subsequently received his B.S. degree in the study of Biology from the University of Texas at Dallas in 1999. In 2006, he completed his Ph.D. in Neuroscience from Tulane University in New Orleans, where he worked with Dr. Bret N. Smith (currently at the University of Kentucky). He joined the Division of Hypothalamic Research in the Department of Internal Medicine here at UT Southwestern, following completion of his postdoctoral studies with Dr. Joel K. Elmquist.  His lab uses mouse genetics, electrophysiology, and systems neuroscience approaches to study the cellular mechanisms within the brain which may underlie the coordinated control of food intake, body weight, and glucose homeostasis.

Education

Undergraduate
University of Texas at Dallas (1999), Biology
Graduate School
Tulane University of Louisiana (2006), Cognition and Neuroscience

Research Interest

  • Central Autonomic Control
  • Diabetes and Glucose Homeostasis
  • Electrophysiology
  • Neurophysiology
  • Obesity and Body Weight Homeostasis
  • Synaptic Transmission

Publications

Featured Publications LegendFeatured Publications

High-fat feeding promotes obesity via insulin receptor/PI3K-dependent inhibition of SF-1 VMH neurons.
Klöckener T, Hess S, Belgardt BF, Paeger L, Verhagen LA, Husch A, Sohn JW, Hampel B, Dhillon H, Zigman JM, Lowell BB, Williams KW, Elmquist JK, Horvath TL, Kloppenburg P, Brüning JC Nat. Neurosci. 2011 14 7 911-8
5-HT2CRs expressed by pro-opiomelanocortin neurons regulate insulin sensitivity in liver.
Xu Y, Berglund ED, Sohn JW, Holland WL, Chuang JC, Fukuda M, Rossi J, Williams KW, Jones JE, Zigman JM, Lowell BB, Scherer PE, Elmquist JK Nat. Neurosci. 2010 Dec 13 12 1457-9
Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility
Hill JW, Elias CF, Fukuda M, Williams KW, Berglund ED, Holland WL, Cho YR, Chuang JC, Xu Y, Choi M, Lauzon D, Lee CE, Coppari R, Richardson JA, Zigman JM, Chua S, Scherer PE, Lowell BB, Bruning JC, Elmquist JK. Cell Metab April 2010 11(4) 286-97
Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility.
Hill JW, Elias CF, Fukuda M, Williams KW, Berglund ED, Holland WL, Cho YR, Chuang JC, Xu Y, Choi M, Lauzon D, Lee CE, Coppari R, Richardson JA, Zigman JM, Chua S, Scherer PE, Lowell BB, Brüning JC, Elmquist JK Cell Metab. 2010 Apr 11 4 286-97
Segregation of acute leptin and insulin effects in distinct populations of arcuate proopiomelanocortin neurons.
Williams KW, Margatho LO, Lee CE, Choi M, Lee S, Scott MM, Elias CF, Elmquist JK J. Neurosci. 2010 Feb 30 7 2472-9
Morphological and electrophysiological features of motor neurons and putative interneurons in the dorsal vagal complex of rats and mice.
Gao H, Glatzer NR, Williams KW, Derbenev AV, Liu D, Smith BN Brain Res. 2009 Sep 1291 40-52
From observation to experimentation: leptin action in the mediobasal hypothalamus.
Williams KW, Scott MM, Elmquist JK Am. J. Clin. Nutr. 2009 Mar 89 3 985S-990S
5-HT2CRs expressed by pro-opiomelanocortin neurons regulate energy homeostasis
Xu Y, Jones JE, Kohno D, Williams KW, Lee CE, Choi MJ, Anderson JG, Heisler LK, Zigman JM, Lowell BB, Elmquist JK Neuron November 2008 60(4) 582-9
5-HT2CRs expressed by pro-opiomelanocortin neurons regulate energy homeostasis.
Xu Y, Jones JE, Kohno D, Williams KW, Lee CE, Choi MJ, Anderson JG, Heisler LK, Zigman JM, Lowell BB, Elmquist JK Neuron 2008 Nov 60 4 582-9
Brain SIRT1: anatomical distribution and regulation by energy availability
Ramadori G, Lee CE, Bookout AL, Lee S, Williams KW, Anderson J, Elmquist JK, Coppari R. J Neurosci October 2008 28(40) 9989-96

Honors & Awards

  • Mentored Research Scientist Development Award
    NIH-NIDDK (087780) (2010)
  • Post-Doctoral Ruth L. Kirschstein National Research Service Award
    NIH-NIDDK (DK077487) (2006)
  • Senior Vice President's award for excellence in research and presentation by a graduate student
    Tulane University - research days (2004)
  • B.S. awarded with cum laude
    The University of Texas at Dallas (1999)
  • A.S. awarded with magna cum laude
    Collin County Community College (1997)
  • UTD Redman scholars program recipient
    Redman Foundation Scholarship (1997)

Professional Associations/Affiliations

  • The Endocrine Society (2011)
  • The Society for Neuroscience (2002)