Dr. Williams received his A.S. degree from Collin County Community College in 1997. Dr. Williams subsequently received his B.S. degree in the study of Biology from the University of Texas at Dallas in 1999. In 2006, he completed his Ph.D. in Neuroscience from Tulane University in New Orleans, where he worked with Dr. Bret N. Smith (currently at the University of Kentucky). He joined the Division of Hypothalamic Research in the Department of Internal Medicine here at UT Southwestern, following completion of his postdoctoral studies with Dr. Joel K. Elmquist. His lab uses mouse genetics, electrophysiology, and systems neuroscience approaches to study the cellular mechanisms within the brain which may underlie the coordinated control of food intake, body weight, and glucose homeostasis.
- Central Autonomic Control
- Diabetes and Glucose Homeostasis
- Obesity and Body Weight Homeostasis
- Synaptic Transmission
- Cellular and synaptic reorganization of arcuate NPY/AgRP and POMC neurons after exercise.
- He Z, Gao Y, Alhadeff AL, Castorena CM, Huang Y, Lieu L, Afrin S, Sun J, Betley JN, Guo H, Williams KW Mol Metab 2018 Sep
- Neural Control of Energy Balance: Translating Circuits to Therapies.
- Gautron L, Elmquist JK, Williams KW Cell 2015 Mar 161 1 133-145
- Xbp1s in Pomc Neurons Connects ER Stress with Energy Balance and Glucose Homeostasis.
- Williams KW, Liu T, Kong X, Fukuda M, Deng Y, Berglund ED, Deng Z, Gao Y, Liu T, Sohn JW, Jia L, Fujikawa T, Kohno D, Scott MM, Lee S, Lee CE, Sun K, Chang Y, Scherer PE, Elmquist JK Cell Metab. 2014 Jul
- Melanocortin 4 receptors reciprocally regulate sympathetic and parasympathetic preganglionic neurons.
- Sohn JW, Harris LE, Berglund ED, Liu T, Vong L, Lowell BB, Balthasar N, Williams KW, Elmquist JK Cell 2013 Jan 152 3 612-9
- From neuroanatomy to behavior: central integration of peripheral signals regulating feeding behavior.
- Williams KW, Elmquist JK Nat. Neurosci. 2012 Oct 15 10 1350-5
- Serotonin 2C receptor activates a distinct population of arcuate pro-opiomelanocortin neurons via TRPC channels.
- Sohn JW, Xu Y, Jones JE, Wickman K, Williams KW, Elmquist JK Neuron 2011 Aug 71 3 488-97
- Segregation of acute leptin and insulin effects in distinct populations of arcuate proopiomelanocortin neurons
- Williams KW, Margatho LO, Lee CE, Choi M, Lee S, Scott MM, Elias CF, Elmquist JK J Neurosci February 2010 30(7) 2472-9
- Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice
- Hill JW, Williams KW, Ye C, Luo J, Balthasar N, Coppari R, Cowley MA, Cantley LC, Lowell BB, Elmquist JK. J Clin Invest May 2008 118(5) 1796-805
- Acute effects of zinc and insulin on arcuate anorexigenic proopiomelanocortin neurons.
- He Z, Gao Y, Lieu L, Afrin S, Guo H, Williams KW Br. J. Pharmacol. 2018 Dec
- Phosphoinositide 3-Kinase Is Integral for the Acute Activity of Leptin and Insulin in Male Arcuate NPY/AgRP Neurons.
- Huang Y, He Z, Gao Y, Lieu L, Yao T, Sun J, Liu T, Javadi C, Box M, Afrin S, Guo H, Williams KW J Endocr Soc 2018 Jun 2 6 518-532
Honors & Awards
- Mentored Research Scientist Development Award
NIH-NIDDK (087780) (2010)
- Post-Doctoral Ruth L. Kirschstein National Research Service Award
NIH-NIDDK (DK077487) (2006)
- Senior Vice President's award for excellence in research and presentation by a graduate student
Tulane University - research days (2004)
- B.S. awarded with cum laude
The University of Texas at Dallas (1999)
- A.S. awarded with magna cum laude
Collin County Community College (1997)
- UTD Redman scholars program recipient
Redman Foundation Scholarship (1997)
- The Endocrine Society (2011)
- The Society for Neuroscience (2002)