Dr. Caroline Smith joined UT Southwestern as an Instructor in the Department of Pediatrics in the Division of Hematology and Oncology in 2023. Dr. Smith earned her undergraduate degree in Human Biology with a minor in American Studies at Stanford University. She completed her medical degree at UT Southwestern and her residency training in Pediatrics at Boston Children’s Hospital and Boston Medical Center in the Boston Combined Residency Program (BCRP). Ultimately, she returned to UT Southwestern / Children’s Medical Center Dallas for her fellowship training in Pediatric Hematology and Oncology.  


Dr. Smith’s clinical and research interests include leukemia and lymphoma, in particular, studying the role of novel targeted cancer therapeutics in patients with relapsed or refractory leukemia. Dr. Smith conducts her research in the Alec Zhang Lab under the co-mentorship of Dr. Samuel John, studying the role of the tumor microenvironment and a novel CAR-T cell therapy in infant leukemia and other leukemias with KMT2A rearrangements.     


Medical School
UT Southwestern Medical School (2017)
Boston Children's Hospital (2020), Pediatrics
UT Southwestern Medical Center (2023), Pediatric Hematology/oncology

Research Interest

  • Acute Lymphoblastic Leukemia (ALL)
  • Acute Myeloid Leukemia (AML)
  • Cellular & Targeted Therapies
  • Infant Leukemia
  • Lymphoma
  • Relapsed and Refractory Leukemia


Featured Publications LegendFeatured Publications

Metachronous diagnosis of synovial sarcoma and papillary thyroid carcinoma in a child.
Yang AT, Smith C, Callan A, Liu C, Stewart R, Sengupta A, Leavey PJ, Pediatr Blood Cancer 2021 Aug e29310
A familial syndrome of pulmonary nontuberculous mycobacteria infections.
Leung JM, Fowler C, Smith C, Adjemian J, Frein C, Claypool RJ, Holland SM, Prevots RD, Olivier K, Am J Respir Crit Care Med 2013 Dec 188 11 1373-6
Abnormal nasal nitric oxide production, ciliary beat frequency, and Toll-like receptor response in pulmonary nontuberculous mycobacterial disease epithelium.
Fowler CJ, Olivier KN, Leung JM, Smith CC, Huth AG, Root H, Kuhns DB, Logun C, Zelazny A, Frein CA, Daub J, Haney C, Shelhamer JH, Bryant CE, Holland SM, Am J Respir Crit Care Med 2013 Jun 187 12 1374-81

Honors & Awards

  • Alpha Omega Alpha (AOA)
  • Kurt Ian Wey Senior Pediatrics Award
    Top medical student entering pediatrics (2017)

Professional Associations/Affiliations

  • Alpha Omega Alpha (AOA) (2017)
  • American Academy of Pediatrics (AAP) (2017)
  • American Society of Clinical Oncology (ASCO) (2020)
  • American Society of Hematology (ASH) (2020)
  • American Society of Pediatric Hematology/Oncology (ASPHO) (2020)
  • Children's Oncology Group (COG) (2020)