Dr. Wang grew up in Houston and received his B.S. from Stanford University. He then enrolled in the Tri-Institutional M.D./Ph.D. Program in New York. He completed his graduate work with Titia de Lange at The Rockefeller University where he studied the role of telomeres in the growth of both normal and transformed cells.
After receiving his M.D. from Cornell in 2006, he returned to Texas to complete his internship in internal medicine and residency in dermatology at UT Southwestern. He received support from the UTSW Physician Scientist Training Program and the Dermatology Foundation to do a research fellowship with Beth Levine.
His research focuses on pathways central to both the development of normal skin and non-melanoma skin cancer tumorigenesis. Specific areas of interest include autophagy and glucose transport. Research in the laboratory is supported by a K08 grant from the NIH/NCI and a Career Award for Medical Scientists from the Burroughs Wellcome Fund.
Dr. Wang practices general dermatology and has an interest in immunosuppressed patients with skin cancers or viral infections, including emerging polyomaviruses.
- Graduate School
- Rockefeller University (2005)
- Medical School
- Weill Cornell Medical College (2006)
- UT Southwestern Medical Center (2007), Internal Medicine
- UT Southwestern Medical Center (2010), Dermatology
- Glucose Transport and Metabolism
- Merkel Cell Carcinoma
- Skin Cancer
- Differential glucose requirement in skin homeostasis and injury identifies a therapeutic target for psoriasis.
- Zhang Z, Zi Z, Lee EE, Zhao J, Contreras DC, South AP, Abel ED, Chong BF, Vandergriff T, Hosler GA, Scherer PE, Mettlen M, Rathmell JC, DeBerardinis RJ, Wang RC Nat. Med. 2018 Apr
- Human polyomavirus 6 and 7 are associated with pruritic and dyskeratotic dermatoses.
- Nguyen KD, Lee EE, Yue Y, Stork J, Pock L, North JP, Vandergriff T, Cockerell C, Hosler GA, Pastrana DV, Buck CB, Wang RC J. Am. Acad. Dermatol. 2016 Dec
- A Protein Kinase C Phosphorylation Motif in GLUT1 Affects Glucose Transport and is Mutated in GLUT1 Deficiency Syndrome.
- Lee EE, Ma J, Sacharidou A, Mi W, Salato VK, Nguyen N, Jiang Y, Pascual JM, North PE, Shaul PW, Mettlen M, Wang RC Mol. Cell 2015 May
- A Primary Melanoma and its Asynchronous Metastasis Highlight the Role of BRAF, CDKN2A, and TERT.
- Hosler GA, Davoli T, Mender I, Litzner B, Choi J, Kapur P, Shay JW, Wang RC J. Cutan. Pathol. 2014 Nov
- Akt-mediated regulation of autophagy and tumorigenesis through Beclin 1 phosphorylation.
- Wang RC, Wei Y, An Z, Zou Z, Xiao G, Bhagat G, White M, Reichelt J, Levine B Science 2012 Nov 338 6109 956-9
- Viral-associated trichodysplasia spinulosa: a case with electron microscopic and molecular detection of the trichodysplasia spinulosa-associated human polyomavirus.
- Matthews MR, Wang RC, Reddick RL, Saldivar VA, Browning JC J. Cutan. Pathol. 2011 May 38 5 420-31
- Homologous recombination generates T-loop-sized deletions at human telomeres.
- Wang RC, Smogorzewska A, de Lange T Cell 2004 Oct 119 3 355-68
- A case of disseminated follicular spicules in human immunodeficiency virus-associated follicular syndrome in the absence of the seven known human polyomaviruses, suggesting that this disorder is distinct from trichodysplasia spinulosa.
- Maddy AJ, Lee EE, Maderal AD, Wang RC, Tosti A, Cho-Vega JH Br. J. Dermatol. 2018 Mar
- Glucose Uptake in Heterologous Expression Systems.
- Lee EE, Wang RC Methods Mol. Biol. 2018 1713 57-67
- Mitochondrial dysregulation and glycolytic insufficiency functionally impair CD8 T cells infiltrating human renal cell carcinoma.
- Siska PJ, Beckermann KE, Mason FM, Andrejeva G, Greenplate AR, Sendor AB, Chiang YJ, Corona AL, Gemta LF, Vincent BG, Wang RC, Kim B, Hong J, Chen CL, Bullock TN, Irish JM, Rathmell WK, Rathmell JC JCI Insight 2017 Jun 2 12
Honors & Awards
- Burroughs Wellcome Fund Career Award for Medical Scientists
- The Dermatology Foundation Physician Scientist Career Development Award
- Stanford University President’s Scholar
- American Academy of Dermatology (2011)
- Society of Investigative Dermatology (2007)