Richard Wang, M.D., Ph.D.

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Dr. Wang grew up in Houston and received his B.S. from Stanford University. He then enrolled in the Tri-Institutional M.D./Ph.D. Program in New York. He completed his graduate work with Titia de Lange at The Rockefeller University where he studied the role of telomeres in the growth of both normal and transformed cells.

After receiving his M.D. from Cornell in 2006, he returned to Texas to complete his internship in internal medicine and residency in dermatology at UT Southwestern. He received support from the UTSW Physician Scientist Training Program and the Dermatology Foundation to do a research fellowship with Beth Levine.

His research focuses on pathways central to both the development of normal skin and non-melanoma skin cancer tumorigenesis. Specific areas of interest include glucose transport/metabolism and DNA tumor viruses. Research in the laboratory is supported by a R01 grant from the NIH/NIAMS and the American Cancer Society.

Dr. Wang practices general dermatology and has an interest in immunosuppressed patients with skin cancers or viral infections.

Graduate School

Rockefeller University (2005)

Other Post Graduate Training

Rockefeller University (2005)

Medical School

Weill Cornell Medical College (2006)

Internship

UT Southwestern Medical Center (2007), Internal Medicine

Residency

UT Southwestern Medical Center (2010), Dermatology

• Glucose Transport and Metabolism
• Merkel Cell Carcinoma
• Papillomaviruses and Polyomaviruses
• Skin Cancer

Featured Publications

Transforming activity of an oncoprotein-encoding circular RNA from human papillomavirus.

Zhao J, Lee EE, Kim J, Yang R, Chamseddin B, Ni C, Gusho E, Xie Y, Chiang CM, Buszczak M, Zhan X, Laimins L, Wang RC, Nat Commun 2019 05 10 1 2300

Differential glucose requirement in skin homeostasis and injury identifies a therapeutic target for psoriasis.

Zhang Z, Zi Z, Lee EE, Zhao J, Contreras DC, South AP, Abel ED, Chong BF, Vandergriff T, Hosler GA, Scherer PE, Mettlen M, Rathmell JC, DeBerardinis RJ, Wang RC Nat. Med. 2018 Apr

Somatic mutations in telomerase promoter counterbalance germline loss-of-function mutations.

Maryoung L, Yue Y, Young A, Newton CA, Barba C, van Oers NS, Wang RC, Garcia CK J. Clin. Invest. 2017 Mar 127 3 982-986

Human polyomavirus 6 and 7 are associated with pruritic and dyskeratotic dermatoses.

Nguyen KD, Lee EE, Yue Y, Stork J, Pock L, North JP, Vandergriff T, Cockerell C, Hosler GA, Pastrana DV, Buck CB, Wang RC J. Am. Acad. Dermatol. 2016 Dec

Glutathione Depletion, Pentose Phosphate Pathway Activation, and Hemolysis in Erythrocytes Protecting Cancer Cells from Vitamin C Induced Oxidative Stress.

Zhang ZZ, Lee EE, Sudderth J, Yue Y, Zia A, Glass D, DeBerardinis RJ, Wang RC J. Biol. Chem. 2016 Sep

A Protein Kinase C Phosphorylation Motif in GLUT1 Affects Glucose Transport and is Mutated in GLUT1 Deficiency Syndrome.

Lee EE, Ma J, Sacharidou A, Mi W, Salato VK, Nguyen N, Jiang Y, Pascual JM, North PE, Shaul PW, Mettlen M, Wang RC Mol. Cell 2015 May

Akt-mediated regulation of autophagy and tumorigenesis through Beclin 1 phosphorylation.

Wang RC, Wei Y, An Z, Zou Z, Xiao G, Bhagat G, White M, Reichelt J, Levine B Science 2012 Nov 338 6109 956-9

Homologous recombination generates T-loop-sized deletions at human telomeres.

Wang RC, Smogorzewska A, de Lange T Cell 2004 Oct 119 3 355-68

Trichodysplasia spinulosa in a child: Identification of trichodysplasia spinulosa-associated polyomavirus in skin, serum, and urine.

Chamseddin BH, Tran BAPD, Lee EE, Pastrana DV, Buck CB, Wang RC, Kirkorian AY, Pediatr Dermatol 2019 Jun

The Biology and Clinical Features of Cutaneous Polyomaviruses.

Nguyen KD, Chamseddin BH, Cockerell CJ, Wang RC J. Invest. Dermatol. 2019 Feb 139 2 285-292

• Burroughs Wellcome Fund Career Award for Medical Scientists
  (2012)
• The Dermatology Foundation Physician Scientist Career Development Award
  (2011)
• Stanford University President’s Scholar
  (1998)

• American Academy of Dermatology (2011)
• Society of Investigative Dermatology (2007)