Biography

I started my neuroscience training by recording in vivo sympathetic nerve discharge activities in rats. My early publications during my PhD were to address “the effects of cannabinoids on the central regulation of cardiovascular function”. I received a scholarship from the British Council and joined a research team of excellent electrophysiologists at Neuroscience Institute in Dundee, Scotland. There I worked in the labs of Dr Andy Irving and Dr Jeremy Lambert. During that time, I was investigating the role of satiety hormone leptin on hippocampal learning and memory and trying to elucidate the mechanisms of barbiturates on thalamo-cortical functions such as sleep and general anesthesia. As a postdoc I focused on in vitro slice electrophysiology and studied hippocampal synaptic plasticity and GABAergic currents. Currently I’m working at the Translational Neurodegeneration Research Center and we are studying the effects of ApoE and its receptors in the pathogenesis of Neurodegenerative Disease including aging, Alzheimer`s Disease, autism and epilepsy.

Education

Medical School
Hacettepe University (1996), Medicine
Graduate School
Hacettepe University (2003), Pharmacology

Research Interest

  • ALZHEIMER`S DISEASE
  • APOE RECEPTORS
  • ELECTROPHYSIOLOGY
  • NEUROSCIENCE
  • REELIN

Publications

Featured Publications LegendFeatured Publications

Leptin induces a novel form of NMDA receptor-dependent long-term depression.
Durakoglugil M, Irving AJ, Harvey J, J. Neurochem. 2005 Oct 95 2 396-405
Transient intrauterine hypotension causes apoptosis in fetal rat brain and affects learning.
Tombakoglu M, Durakoglugil M, Kale G, Orer HS, Bulun A, Anlar B, Pediatr. Res. 2003 Jun 53 6 977-82
Contralateral genitofemoral sympathetic nerve discharge increases following ipsilateral testicular torsion.
Otçu S, Durakogugil M, Orer HS, Tanyel FC, Urol. Res. 2002 Oct 30 5 324-8