Rashmin Savani was born in Masaka, Uganda, received his primary education there,and then completed schooling at King Edward VII School in Sheffield, England (1977). He obtained his medical degree from the University of Sheffield (1982). He undertook internships in Internal Medicine, General Surgery and Obstetrics & Gynecology from 1982 to 1984. He was a pediatric resident at Duke University Medical Center (1984-1987) and a fellow in Neonatology (1987-1989) and in Pulmonary Biology (1989-1991) at Cincinnati Children’s Medical Center. He then moved to the University of Manitoba and Winnipeg Children’s Hospital where he was an Assistant Professor of Pediatrics in the Section of Neonatology (1991-1996). He undertook further postgraduate training in Cell & Molecular Biology at the Manitoba Institute of Cell Biology (1991-1994) after which he had an independent laboratory at the Institute. He was recruited to the University of Pennsylvania and Children’s Hospital of Philadelphia (1996-2006) and rose to the rank of Associate Professor with Tenure in 2002. His research focus has been on lung injury and development, including inflammation and angiogenesis. He has maintained continuous extramural funding since 1998. Dr. Savani moved from CHOP/PENN in 2006 to become Professor of Pediatrics. He was awarded the William Buchanan Chair in Pediatrics in 2006 and is currently Division Director of Neonatal-Perinatal Medicine and Associate Director of Pulmonary & Vascular Biology in the Department of Pediatrics.
- Medical School
- The University of Sheffield Medical School (1982)
- Royal Hallamshire Hospital (1983), Internal Medicine
- Northern General Hospital (1983), General Surgery
- Peterborough District Hospital (1984), Obstetrics & Gynecology
- Duke University Medical Center (1987), Pediatrics
- Cincinnati Children's Hospital Medical Center (1991), Neonatal-perinatal Medicine
- University of Manitoba (1994), Cell Biology
- Apical oxidative hyaluronan degradation stimulates airway ciliary beating via RHAMM and RON.
- Manzanares D, Monzon ME, Savani RC, Salathe M Am. J. Respir. Cell Mol. Biol. 2007 Aug 37 2 160-8
- SP-D-deficient mice are resistant to hyperoxia.
- Jain D, Atochina-Vasserman E, Kadire H, Tomer Y, Inch A, Scott P, Savani RC, Gow AJ, Beers MF Am. J. Physiol. Lung Cell Mol. Physiol. 2007 Apr 292 4 L861-71
- Inflammatory markers and mediators in tracheal fluid of premature infants treated with inhaled nitric oxide.
- Truog WE, Ballard PL, Norberg M, Golombek S, Savani RC, Merrill JD, Parton LA, Cnaan A, Luan X, Ballard RA Pediatrics 2007 Apr 119 4 670-8
- Role of endogenous TGF-beta in glucocorticoid-induced lung type II cell differentiation.
- McDevitt TM, Gonzales LW, Savani RC, Ballard PL Am. J. Physiol. Lung Cell Mol. Physiol. 2007 Jan 292 1 L249-57
- Hyaluronan-mediated angiogenesis in vascular disease: uncovering RHAMM and CD44 receptor signaling pathways.
- Slevin M, Krupinski J, Gaffney J, Matou S, West D, Delisser H, Savani RC, Kumar S Matrix Biol. 2007 Jan 26 1 58-68
- Involvement of endothelial CD44 during in vivo angiogenesis.
- Cao G, Savani RC, Fehrenbach M, Lyons C, Zhang L, Coukos G, Delisser HM Am. J. Pathol. 2006 Jul 169 1 325-36
- Loss of PECAM-1 function impairs alveolarization.
- DeLisser HM, Helmke BP, Cao G, Egan PM, Taichman D, Fehrenbach M, Zaman A, Cui Z, Mohan GS, Baldwin HS, Davies PF, Savani RC J. Biol. Chem. 2006 Mar 281 13 8724-31
- Surfactant composition and function in a primate model of infant chronic lung disease: effects of inhaled nitric oxide.
- Ballard PL, Gonzales LW, Godinez RI, Godinez MH, Savani RC, McCurnin DC, Gibson LL, Yoder BA, Kerecman JD, Grubb PH, Shaul PW Pediatr. Res. 2006 Jan 59 1 157-62
- Hormonal regulation of alveolarization: structure-function correlation.
- Garber SJ, Zhang H, Foley JP, Zhao H, Butler SJ, Godinez RI, Godinez MH, Gow AJ, Savani RC Respir. Res. 2006 7 47
- Expression and role of the hyaluronan receptor RHAMM in inflammation after bleomycin injury.
- Zaman A, Cui Z, Foley JP, Zhao H, Grimm PC, Delisser HM, Savani RC Am. J. Respir. Cell Mol. Biol. 2005 Nov 33 5 447-54
Modulators of inflammation in Bronchopulmonary Dysplasia. In Seminars in Perinatology
Savani RC (2018). Elsevier, Inc; 459-470
Molecular Basis for Lung Development, Injury and Repair. In The Newborn Lung, 3rd ed, Bancalari E, Keszler M, Davis PG, eds.
Wu S, Savani RC (2018). Philadelphia, PA, Elsevier; 3-29
The Biochemistry of Endothelial Cells. In Parent RA, ed. Comparative Biology of the Lung. 2nd ed.
Savani RC. (2015). Academic Press; 375-386.
Hyaluronan and Its Receptors in Lung Health and Disease. In Garg HG, Roughley PJ, Hales CA, eds. Lung Biology in Health and Disease Series: Proteoglycans in Lung Disease.
Savani RC, DeLisser HM. (2002). CRC Press; 73-106.
Honors & Awards
- Albert Nelson Marquis Lifetime Achievement Award
Marquis Whos Who Publications Board (2017-2018)
- Texas Super Doctors
Texas Monthly (2015-2018)
- Invited membership, International Perinatal Collegium
- Best Doctors in America
- Perinatal Physician Excellence Award
March of Dimes, Texas (2010)
- Honorary Masters of Arts
University of Pennsylvania School of Medicine (2002)
- Young Investigator Award, Perinatal Pediatrics
American Academy of Pediatrics (1998)
- Young Investigator Award, Basic Science
Eastern Society for Pediatric Research (1997)
- American Pediatric Society, Member (2005)
- American Physiological Society, Member (2005-2010)
- American Society for Biochemistry and Molecular Biology, Member (2005-2010)
- The International Society for Hyaluronan Science, Member of the Board (2004)
- Perinatal Research Society, Member (1999)
- Society for Pediatric Research, Member (1999)