Rashmin Savani was born in Masaka, Uganda, received his primary education there,and then completed schooling at King Edward VII School in Sheffield, England (1977). He obtained his medical degree from the University of Sheffield (1982). He undertook internships in Internal Medicine, General Surgery and Obstetrics & Gynecology from 1982 to 1984. He was a pediatric resident at Duke University Medical Center (1984-1987) and a fellow in Neonatology (1987-1989) and in Pulmonary Biology (1989-1991) at Cincinnati Children’s Medical Center. He then moved to the University of Manitoba and Winnipeg Children’s Hospital where he was an Assistant Professor of Pediatrics in the Section of Neonatology (1991-1996). He undertook further postgraduate training in Cell & Molecular Biology at the Manitoba Institute of Cell Biology (1991-1994) after which he had an independent laboratory at the Institute. He was recruited to the University of Pennsylvania and Children’s Hospital of Philadelphia (1996-2006) and rose to the rank of Associate Professor with Tenure in 2002. His research focus has been on lung injury and development, including inflammation and angiogenesis. He has maintained continuous extramural funding since 1998. Dr. Savani moved from CHOP/PENN in 2006 to become Professor of Pediatrics. He was awarded the William Buchanan Chair in Pediatrics in 2006 and is currently Division Director of Neonatal-Perinatal Medicine and Associate Director of Pulmonary & Vascular Biology in the Department of Pediatrics.
- Medical School
- The University of Sheffield Medical School (1982)
- Royal Hallamshire Hospital (1983), Internal Medicine
- Northern General Hospital (1983), General Surgery
- Peterborough District Hospital (1984), Obstetrics & Gynecology
- Duke University Medical Center (1987), Pediatrics
- Cincinnati Children's Hospital Medical Center (1991), Neonatal-perinatal Medicine
- University of Manitoba (1994), Cell Biology
- Imaging of homeostatic, neoplastic, and injured tissues by HA-based probes.
- Veiseh M, Breadner D, Ma J, Akentieva N, Savani RC, Harrison R, Mikilus D, Collis L, Gustafson S, Lee TY, Koropatnick J, Luyt LG, Bissell MJ, Turley EA Biomacromolecules 2012 Jan 13 1 12-22
- Antioxidant protects against increases in low molecular weight hyaluronan and inflammation in asphyxiated newborn pigs resuscitated with 100% oxygen.
- Østerholt HC, Dannevig I, Wyckoff MH, Liao J, Akgul Y, Ramgopal M, Mija DS, Cheong N, Longoria C, Mahendroo M, Nakstad B, Saugstad OD, Savani RC PLoS ONE 2012 7 6 e38839
- Inhibition of oesophageal squamous cell carcinoma progression by in vivo targeting of hyaluronan synthesis.
- Twarock S, Freudenberger T, Poscher E, Dai G, Jannasch K, Dullin C, Alves F, Prenzel K, Knoefel WT, Stoecklein NH, Savani RC, Homey B, Fischer JW Mol. Cancer 2011 10 30
- Hyaluronan stabilizes focal adhesions, filopodia, and the proliferative phenotype in esophageal squamous carcinoma cells.
- Twarock S, Tammi MI, Savani RC, Fischer JW J. Biol. Chem. 2010 Jul 285 30 23276-84
- Hyaluronan mediates ozone-induced airway hyperresponsiveness in mice.
- Garantziotis S, Li Z, Potts EN, Kimata K, Zhuo L, Morgan DL, Savani RC, Noble PW, Foster WM, Schwartz DA, Hollingsworth JW J. Biol. Chem. 2009 Apr 284 17 11309-17
- The angiogenic factor midkine is regulated by dexamethasone and retinoic acid during alveolarization and in alveolar epithelial cells.
- Zhang H, Garber SJ, Cui Z, Foley JP, Mohan GS, Jobanputra M, Kaplan F, Sweezey NB, Gonzales LW, Savani RC Respir. Res. 2009 10 77
- S-nitrosylation of surfactant protein-D controls inflammatory function.
- Guo CJ, Atochina-Vasserman EN, Abramova E, Foley JP, Zaman A, Crouch E, Beers MF, Savani RC, Gow AJ PLoS Biol. 2008 Nov 6 11 e266
- Interaction of CD44 and hyaluronan is the dominant mechanism for neutrophil sequestration in inflamed liver sinusoids.
- McDonald B, McAvoy EF, Lam F, Gill V, de la Motte C, Savani RC, Kubes P J. Exp. Med. 2008 Apr 205 4 915-27
- ABCA3 is critical for lamellar body biogenesis in vivo.
- Cheong N, Zhang H, Madesh M, Zhao M, Yu K, Dodia C, Fisher AB, Savani RC, Shuman H J. Biol. Chem. 2007 Aug 282 33 23811-7
- CD44 regulates macrophage recruitment to the lung in lipopolysaccharide-induced airway disease.
- Hollingsworth JW, Li Z, Brass DM, Garantziotis S, Timberlake SH, Kim A, Hossain I, Savani RC, Schwartz DA Am. J. Respir. Cell Mol. Biol. 2007 Aug 37 2 248-53
Modulators of inflammation in Bronchopulmonary Dysplasia. In Seminars in Perinatology
Savani RC (2018). Elsevier, Inc; 459-470
Molecular Basis for Lung Development, Injury and Repair. In The Newborn Lung, 3rd ed, Bancalari E, Keszler M, Davis PG, eds.
Wu S, Savani RC (2018). Philadelphia, PA, Elsevier; 3-29
The Biochemistry of Endothelial Cells. In Parent RA, ed. Comparative Biology of the Lung. 2nd ed.
Savani RC. (2015). Academic Press; 375-386.
Hyaluronan and Its Receptors in Lung Health and Disease. In Garg HG, Roughley PJ, Hales CA, eds. Lung Biology in Health and Disease Series: Proteoglycans in Lung Disease.
Savani RC, DeLisser HM. (2002). CRC Press; 73-106.
Honors & Awards
- Albert Nelson Marquis Lifetime Achievement Award
Marquis Whos Who Publications Board (2017-2018)
- Texas Super Doctors
Texas Monthly (2015-2018)
- Invited membership, International Perinatal Collegium
- Best Doctors in America
- Perinatal Physician Excellence Award
March of Dimes, Texas (2010)
- Honorary Masters of Arts
University of Pennsylvania School of Medicine (2002)
- Young Investigator Award, Perinatal Pediatrics
American Academy of Pediatrics (1998)
- Young Investigator Award, Basic Science
Eastern Society for Pediatric Research (1997)
- American Pediatric Society, Member (2005)
- American Physiological Society, Member (2005-2010)
- American Society for Biochemistry and Molecular Biology, Member (2005-2010)
- The International Society for Hyaluronan Science, Member of the Board (2004)
- Perinatal Research Society, Member (1999)
- Society for Pediatric Research, Member (1999)