Helen Lai, Ph.D.

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Undergraduate

Cornell University (2005), Chemistry

Graduate School

University of California-San F (2005)

Featured Publications

Loss of Prdm12 during development, but not in mature nociceptors, causes defects in pain sensation.

Landy MA, Goyal M, Casey KM, Liu C, Lai HC, Cell Rep 2021 Mar 34 13 108913

Evidence for genetically distinct direct and indirect spinocerebellar pathways mediating proprioception

Iliodora V. Pop, Felipe Espinosa, Megan Goyal, Bishakha Mona, Mark A. Landy, Osita W. Ogujiofor, Kevin M. Dean, Channabasavaiah B. Gurumurthy, Helen C. Lai bioRxiv 2020

Making sense out of spinal cord somatosensory development.

Lai HC, Seal RP, Johnson JE Development 2016 Oct 143 19 3434-3448

Origin of a Non-Clarke's Column Division of the Dorsal Spinocerebellar Tract and the Role of Caudal Proprioceptive Neurons in Motor Function.

Yuengert R, Hori K, Kibodeaux EE, McClellan JX, Morales JE, Huang TW, Neul JL, Lai HC Cell Rep 2015 Nov 13 6 1258-71

In vivo neuronal subtype-specific targets of Atoh1 (Math1) in dorsal spinal cord.

Lai HC, Klisch TJ, Roberts R, Zoghbi HY, Johnson JE J. Neurosci. 2011 Jul 31 30 10859-71

Structure prediction for the down state of a potassium channel voltage sensor.

Grabe M, Lai HC, Jain M, Jan YN, Jan LY Nature 2007 Feb 445 7127 550-3

The distribution and targeting of neuronal voltage-gated ion channels.

Lai HC, Jan LY Nat. Rev. Neurosci. 2006 Jul 7 7 548-62

The S4 voltage sensor packs against the pore domain in the KAT1 voltage-gated potassium channel.

Lai HC, Grabe M, Jan YN, Jan LY Neuron 2005 Aug 47 3 395-406

An Atoh1 CRE knock-in mouse labels motor neurons involved in fine motor control.

Ogujiofor OW, Pop IV, Espinosa F, Durodoye RO, Viacheslavov ML, Jarvis R, Landy MA, Gurumurthy CB, Lai HC, eNeuro 2021 Jan

Single cell RNA sequencing identifies early diversity of sensory neurons forming via bi-potential intermediates.

Faure L, Wang Y, Kastriti ME, Fontanet P, Cheung KKY, Petitpré C, Wu H, Sun LL, Runge K, Croci L, Landy MA, Lai HC, Consalez GG, de Chevigny A, Lallemend F, Adameyko I, Hadjab S, Nat Commun 2020 08 11 1 4175

• Rita Allen Foundation
  (2018-2021)
• Sara and Frank McKnight Fellow
  (2012-2015)
• Ruth L. Kirschstein NRSA F32 Postdoctoral Fellowship
  (2007-2010)
• American Heart Association Pre-doctoral Fellowship
  (2003-2005)