Biography

Dr. Zigman grew up in New Jersey and performed undergraduate studies at Cornell University. He obtained a dual M.D.-Ph.D. degree from the University of Chicago and remained in Chicago to complete an Internal Medicine residency. Dr. Zigman next moved to Beth Israel Deaconess Medical Center in Boston, where he completed a fellowship in Endocrinology, Diabetes and Metabolism. It was in Boston, while working under the mentorship of Drs. Joel Elmquist and Jeffrey Garber, where Dr. Zigman’s research interests in the hormone ghrelin and the CNS control of eating, body weight, and blood glucose and where his clinical interests in thyroid nodular disease and thyroid cancer first arose.

Dr. Zigman is a Professor of Internal Medicine at UT Southwestern, where he is affiliated with the Division of Hypothalamic Research and the Division of Endocrinology & Metabolism. He holds a secondary appointment in the Department of Psychiatry and also is affiliated with the Integrative Molecular and Biomedical Sciences Graduate Program and the Neuroscience Graduate Program.

Dr. Zigman’s clinic primarily focuses on the treatment of individuals with thyroid nodules and thyroid cancer.

Dr. Zigman’s research is geared toward understanding the neuro-hormonal framework underlying metabolism. In particular, the Zigman lab focuses on how gastrointestinal hormones such as ghrelin interact with the brain, peripheral nervous system, and various peripheral organs to control eating, body weight, blood glucose, responses to exercise, and mood. Conditions studied by the lab include obesity, diabetes, hypoglycemia, cachexia, Prader-Willi Syndrome, and depression.

Education

Medical School
University of Chicago Pritzker School of Medicine (1997)
Internship/Residency
University of Chicago Hospitals (2000), Internal Medicine
Fellowship
Beth Israel Deaconess Medical Center (2003), Endocrinology & Metabolism

Research Interest

  • Brain-gut axis
  • Diabetes and hypoglycemia
  • Enteroendocrine cell function
  • Ghrelin secretion and ghrelin action
  • Metabolic responses to Excercise
  • Neuro-hormonal framework linking complex eating behaviors to mood
  • Obesity and eating behavior
  • Prader-Willi Syndrome

Publications

Featured Publications LegendFeatured Publications

Ghrelin and eating behavior: evidence and insights from genetically-modified mouse models.
Uchida A, Zigman JM, Perelló M Front Neurosci 2013 7 121
Disruption of cue-potentiated feeding in mice with blocked ghrelin signaling.
Walker AK, Ibia IE, Zigman JM Physiol. Behav. 2012 Dec 108 34-43
A major lineage of enteroendocrine cells coexpress CCK, secretin, GIP, GLP-1, PYY, and neurotensin but not somatostatin.
Egerod KL, Engelstoft MS, Grunddal KV, Nøhr MK, Secher A, Sakata I, Pedersen J, Windeløv JA, Füchtbauer EM, Olsen J, Sundler F, Christensen JP, Wierup N, Olsen JV, Holst JJ, Zigman JM, Poulsen SS, Schwartz TW Endocrinology 2012 Dec 153 12 5782-95
GOAT induced ghrelin acylation regulates hedonic feeding.
Davis JF, Perello M, Choi DL, Magrisso IJ, Kirchner H, Pfluger PT, Tschoep M, Zigman JM, Benoit SC Horm Behav 2012 Nov 62 5 598-604
The role of ghrelin in reward-based eating.
Perelló M, Zigman JM Biol. Psychiatry 2012 Sep 72 5 347-53
Glucose-mediated control of ghrelin release from primary cultures of gastric mucosal cells.
Sakata I, Park WM, Walker AK, Piper PK, Chuang JC, Osborne-Lawrence S, Zigman JM Am. J. Physiol. Endocrinol. Metab. 2012 May 302 10 E1300-10
Proton- and ammonium-sensing by histaminergic neurons controlling wakefulness.
Yanovsky Y, Zigman JM, Kernder A, Bein A, Sakata I, Osborne-Lawrence S, Haas HL, Sergeeva OA Front Syst Neurosci 2012 6 23
Hindbrain ghrelin receptor signaling is sufficient to maintain fasting glucose.
Scott MM, Perello M, Chuang JC, Sakata I, Gautron L, Lee CE, Lauzon D, Elmquist JK, Zigman JM PLoS ONE 2012 7 8 e44089
Ghrelin indirectly activates hypophysiotropic CRF neurons in rodents.
Cabral A, Suescun O, Zigman JM, Perello M PLoS ONE 2012 7 2 e31462
Genetic tracing of Nav1.8-expressing vagal afferents in the mouse.
Gautron L, Sakata I, Udit S, Zigman JM, Wood JN, Elmquist JK J. Comp. Neurol. 2011 Oct 519 15 3085-101

Books

Featured Books Legend Featured Books

Obesity. In Pocket Primary Care

Zigman J (2001). Philadelphia, Lippincott, Williams, & Wilkins

Mechanisms of homeostatically regulated behaviors. In Neuroscience in the 21st Century

Elmquist J, Zigman J, Saper C. (2011). Berlin, Springer-Verlag GmbH

Honors & Awards

  • Ken and Jodi Foster Distinguished Chair in Endocrinology, in Honor of Daniel Foster, M.D.
    UT Southwestern Medical Center (2016)
  • Top Doctor
    Castle Connolly (2015)
  • Patricia Usher Memorial Lecture Speaker
    Beth Israel Deaconess Medical Center (2014)
  • Class of 2014 (MS2) Outstanding Teaching Award
    UT Southwestern Medical Center (2012)
  • Mr. and Mrs. Bruce G. Brookshire Professorship in Medicine
    UT Southwestern Medical Center (2012)
  • The Diana and Richard C. Strauss Professorship in Biomedical Research
    UT Southwestern Medical Center (2012)
  • Class of 2013 (MS2) Outstanding Teaching Award 2010-2011
    UT Southwestern Medical Center (2011)
  • Top Doctor
    U.S. News & World Report (2011)
  • Class of 2013 (MS1) Outstanding Teaching Award in Physiology
    UT Southwestern Medical Center (2010)
  • Disease-Oriented Clinical Scholar
    UT Southwestern Medical Center (2006-2009)
  • Phi Beta Kappa, Phi Kappa Phi, and Golden Key National Honor Societies
    Cornell University (1989)

Professional Associations/Affiliations

  • Society for the Study of Ingestive Behavior (2019)
  • American Society for Clinical Investigation (2012)
  • American Thyroid Association (2009)
  • The Endocrine Society (2009)
  • The Obesity Society (2008)
  • American Diabetes Association (2004)
  • American Association of Clinical Endocrinologists (2000)