Biography

Dr. Zigman grew up in New Jersey and performed undergraduate studies at Cornell University. He obtained a dual M.D.-Ph.D. degree from the University of Chicago and remained in Chicago to complete an Internal Medicine residency. Dr. Zigman next moved to Beth Israel Deaconess Medical Center in Boston, where he completed a fellowship in Endocrinology, Diabetes and Metabolism. It was in Boston, while working under the mentorship of Drs. Joel Elmquist and Jeffrey Garber, where Dr. Zigman’s research interests in the hormone ghrelin and the CNS control of eating, body weight, and blood glucose and where his clinical interests in thyroid nodular disease and thyroid cancer first arose.

Dr. Zigman is a Professor of Internal Medicine at UT Southwestern, where he is affiliated with the Division of Hypothalamic Research and the Division of Endocrinology & Metabolism. He holds a secondary appointment in the Department of Psychiatry and also is affiliated with the Integrative Molecular and Biomedical Sciences Graduate Program and the Neuroscience Graduate Program.

Dr. Zigman’s clinic primarily focuses on the treatment of individuals with thyroid nodules and thyroid cancer.

Dr. Zigman’s research is geared toward understanding the neuro-hormonal framework underlying metabolism. In particular, the Zigman lab focuses on how gastrointestinal hormones such as ghrelin interact with the brain, peripheral nervous system, and various peripheral organs to control eating, body weight, blood glucose, responses to exercise, and mood. Conditions studied by the lab include obesity, diabetes, hypoglycemia, cachexia, Prader-Willi Syndrome, and depression.

Education

Medical School
University of Chicago Pritzker School of Medicine (1997)
Internship/Residency
University of Chicago Hospitals (2000), Internal Medicine
Fellowship
Beth Israel Deaconess Medical Center (2003), Endocrinology & Metabolism

Research Interest

  • Brain-gut axis
  • Diabetes and hypoglycemia
  • Enteroendocrine cell function
  • Ghrelin secretion and ghrelin action
  • Metabolic responses to Excercise
  • Neuro-hormonal framework linking complex eating behaviors to mood
  • Obesity and eating behavior
  • Prader-Willi Syndrome

Publications

Featured Publications LegendFeatured Publications

Neuroanatomical and functional characterization of CRF neurons of the amygdala using a novel transgenic mouse model.
De Francesco PN, Valdivia S, Cabral A, Reynaldo M, Raingo J, Sakata I, Osborne-Lawrence S, Zigman JM, Perelló M Neuroscience 2015 Jan 289C 153-165
Novel Regulator of Acylated Ghrelin, CF801, Reduces Weight Gain, Rebound Feeding after a Fast, and Adiposity in Mice.
Wellman MK, Patterson ZR, MacKay H, Darling JE, Mani BK, Zigman JM, Hougland JL, Abizaid A Front Endocrinol (Lausanne) 2015 6 144
Altered ghrelin secretion in mice in response to diet-induced obesity and Roux-en-Y gastric bypass.
Uchida A, Zechner JF, Mani BK, Park WM, Aguirre V, Zigman JM Mol Metab 2014 Oct 3 7 717-30
Divergent neuronal circuitries underlying acute orexigenic effects of peripheral or central ghrelin: critical role of brain accessibility.
Cabral A, Valdivia S, Fernandez G, Reynaldo M, Perello M J. Neuroendocrinol. 2014 Aug 26 8 542-54
Neuroanatomical characterization of a growth hormone secretagogue receptor-green fluorescent protein reporter mouse.
Mani BK, Walker AK, LopezSoto EJ, Raingo J, Lee CE, Perelló M, Andrews ZB, Zigman JM J. Comp. Neurol. 2014 May
The P7C3 class of neuroprotective compounds exerts antidepressant efficacy in mice by increasing hippocampal neurogenesis.
Walker AK, Rivera PD, Wang Q, Chuang JC, Tran S, Osborne-Lawrence S, Estill SJ, Starwalt R, Huntington P, Morlock L, Naidoo J, Williams NS, Ready JM, Eisch AJ, Pieper AA, Zigman JM Mol. Psychiatry 2014 Apr
The central nervous system sites mediating the orexigenic actions of ghrelin.
Mason BL, Wang Q, Zigman JM Annu. Rev. Physiol. 2014 Feb 76 519-33
Arcuate AgRP neurons mediate orexigenic and glucoregulatory actions of ghrelin.
Wang Q, Liu C, Uchida A, Chuang JC, Walker A, Liu T, Osborne-Lawrence S, Mason BL, Mosher C, Berglund ED, Elmquist JK, Zigman JM Mol Metab 2014 Feb 3 1 64-72
Estradiol modulates Kiss1 Neuronal Response to Ghrelin.
Frazao R, Dungan-Lemko H, Silva RP, Ratra DV, Lee CE, Williams KW, Zigman JM, Elias CF Am. J. Physiol. Endocrinol. Metab. 2014 Jan
G protein-coupled receptor 120 signaling regulates ghrelin secretion in vivo and in vitro.
Gong Z, Yoshimura M, Aizawa S, Kurotani R, Zigman JM, Sakai T, Sakata I Am. J. Physiol. Endocrinol. Metab. 2014 Jan 306 1 E28-35

Books

Featured Books Legend Featured Books

Obesity. In Pocket Primary Care

Zigman J (2001). Philadelphia, Lippincott, Williams, & Wilkins

Mechanisms of homeostatically regulated behaviors. In Neuroscience in the 21st Century

Elmquist J, Zigman J, Saper C. (2011). Berlin, Springer-Verlag GmbH

Honors & Awards

  • Ken and Jodi Foster Distinguished Chair in Endocrinology, in Honor of Daniel Foster, M.D.
    UT Southwestern Medical Center (2016)
  • Top Doctor
    Castle Connolly (2015)
  • Patricia Usher Memorial Lecture Speaker
    Beth Israel Deaconess Medical Center (2014)
  • Class of 2014 (MS2) Outstanding Teaching Award
    UT Southwestern Medical Center (2012)
  • Mr. and Mrs. Bruce G. Brookshire Professorship in Medicine
    UT Southwestern Medical Center (2012)
  • The Diana and Richard C. Strauss Professorship in Biomedical Research
    UT Southwestern Medical Center (2012)
  • Class of 2013 (MS2) Outstanding Teaching Award 2010-2011
    UT Southwestern Medical Center (2011)
  • Top Doctor
    U.S. News & World Report (2011)
  • Class of 2013 (MS1) Outstanding Teaching Award in Physiology
    UT Southwestern Medical Center (2010)
  • Disease-Oriented Clinical Scholar
    UT Southwestern Medical Center (2006-2009)
  • Phi Beta Kappa, Phi Kappa Phi, and Golden Key National Honor Societies
    Cornell University (1989)

Professional Associations/Affiliations

  • Society for the Study of Ingestive Behavior (2019)
  • American Society for Clinical Investigation (2012)
  • American Thyroid Association (2009)
  • The Endocrine Society (2009)
  • The Obesity Society (2008)
  • American Diabetes Association (2004)
  • American Association of Clinical Endocrinologists (2000)