Biography

Dr. Zigman grew up in New Jersey and performed undergraduate studies at Cornell University. He obtained a dual M.D.-Ph.D. degree from the University of Chicago and remained in Chicago to complete an Internal Medicine residency. Dr. Zigman next moved to Beth Israel Deaconess Medical Center in Boston, where he completed a fellowship in Endocrinology, Diabetes and Metabolism. It was in Boston, while working under the mentorship of Drs. Joel Elmquist and Jeffrey Garber, where Dr. Zigman’s research interests in the hormone ghrelin and the CNS control of eating, body weight, and blood glucose and where his clinical interests in thyroid nodular disease and thyroid cancer first arose.

Dr. Zigman is a Professor of Internal Medicine at UT Southwestern, where he is affiliated with the Division of Hypothalamic Research and the Division of Endocrinology & Metabolism. He holds a secondary appointment in the Department of Psychiatry and also is affiliated with the Integrative Molecular and Biomedical Sciences Graduate Program and the Neuroscience Graduate Program.

Dr. Zigman’s clinic primarily focuses on the treatment of individuals with thyroid nodules and thyroid cancer.

Dr. Zigman’s research is geared toward understanding the neuro-hormonal framework underlying metabolism. In particular, the Zigman lab focuses on how gastrointestinal hormones such as ghrelin interact with the brain, peripheral nervous system, and various peripheral organs to control eating, body weight, blood glucose, responses to exercise, and mood. Conditions studied by the lab include obesity, diabetes, hypoglycemia, cachexia, Prader-Willi Syndrome, and depression.

Education

Medical School
University of Chicago Pritzker School of Medicine (1997)
Internship/Residency
University of Chicago Hospitals (2000), Internal Medicine
Fellowship
Beth Israel Deaconess Medical Center (2003), Endocrinology & Metabolism

Research Interest

  • Brain-gut axis
  • Diabetes and hypoglycemia
  • Enteroendocrine cell function
  • Ghrelin secretion and ghrelin action
  • Metabolic responses to Excercise
  • Neuro-hormonal framework linking complex eating behaviors to mood
  • Obesity and eating behavior
  • Prader-Willi Syndrome

Publications

Featured Publications LegendFeatured Publications

Hypothalamic loss of Snord116 and Prader-Willi syndrome hyperphagia: the buck stops here?
Rodriguez JA, Zigman JM J. Clin. Invest. 2018 Jan
Hypoglycemic Effect of Combined Ghrelin and Glucagon Receptor Blockade.
Mani BK, Uchida A, Lee Y, Osborne-Lawrence S, Charron MJ, Unger RH, Berglund ED, Zigman JM Diabetes 2017 May
Circulating Ghrelin acts on GABA neurons of the area postrema and mediates gastric emptying in male mice.
Cabral A, Cornejo MP, Fernandez G, De Francesco PN, Garcia-Romero G, Uriarte M, Zigman JM, Portiansky E, Reynaldo M, Perello M Endocrinology 2017 Feb
The effect of glutamate on ghrelin release in mice.
Chacrabati R, Gong Z, Ikenoya C, Kondo D, Zigman JM, Sakai T, Sakata I Cell Biol. Int. 2017 Jan
Brain imaging demonstrates a reduced neural impact of eating in obesity.
Puzziferri N, Zigman JM, Thomas BP, Mihalakos P, Gallagher R, Lutter M, Carmody T, Lu H, Tamminga CA Obesity (Silver Spring) 2016 Feb
Ghrelin activates hypophysiotropic corticotropin-releasing factor neurons independently of the arcuate nucleus.
Cabral A, Portiansky E, Sánchez-Jaramillo E, Zigman JM, Perello M Psychoneuroendocrinology 2016 Feb 67 27-39
A Strong Stomach for Somatostatin.
Mani BK, Zigman JM Endocrinology 2015 Nov 156 11 3876-9
Obesity Impairs the Action of the Neuroendocrine Ghrelin System.
Zigman JM, Bouret SG, Andrews ZB Trends Endocrinol. Metab. 2015 Nov
Research Resource: A Chromogranin A Reporter for Serotonin and Histamine Secreting Enteroendocrine Cells.
Engelstoft MS, Lund ML, Grunddal KV, Egerod KL, Osborne-Lawrence S, Seier Poulsen S, Zigman JM, Schwartz TW Mol. Endocrinol. 2015 Sep me20151106
Ghrelin.
Müller TD, Nogueiras R, Andermann ML, Andrews ZB, Anker SD, Argente J, Batterham RL, Benoit SC, Bowers CY, Broglio F, Casanueva FF, D'Alessio D, Depoortere I, Geliebter A, Ghigo E, Cole PA, Cowley M, Cummings DE, Dagher A, Diano S, Dickson SL, Diéguez C, Granata R, Grill HJ, Grove K, Habegger KM, Heppner K, Heiman ML, Holsen L, Holst B, Inui A, Jansson JO, Kirchner H, Korbonits M, Laferrère B, LeRoux CW, Lopez M, Morin S, Nakazato M, Nass R, Perez-Tilve D, Pfluger PT, Schwartz TW, Seeley RJ, Sleeman M, Sun Y, Sussel L, Tong J, Thorner MO, van der Lely AJ, van der Ploeg LH, Zigman JM, Kojima M, Kangawa K, Smith RG, Horvath T, Tschöp MH Mol Metab 2015 Jun 4 6 437-60

Books

Featured Books Legend Featured Books

Obesity. In Pocket Primary Care

Zigman J (2001). Philadelphia, Lippincott, Williams, & Wilkins

Mechanisms of homeostatically regulated behaviors. In Neuroscience in the 21st Century

Elmquist J, Zigman J, Saper C. (2011). Berlin, Springer-Verlag GmbH

Honors & Awards

  • Ken and Jodi Foster Distinguished Chair in Endocrinology, in Honor of Daniel Foster, M.D.
    UT Southwestern Medical Center (2016)
  • Top Doctor
    Castle Connolly (2015)
  • Patricia Usher Memorial Lecture Speaker
    Beth Israel Deaconess Medical Center (2014)
  • Class of 2014 (MS2) Outstanding Teaching Award
    UT Southwestern Medical Center (2012)
  • Mr. and Mrs. Bruce G. Brookshire Professorship in Medicine
    UT Southwestern Medical Center (2012)
  • The Diana and Richard C. Strauss Professorship in Biomedical Research
    UT Southwestern Medical Center (2012)
  • Class of 2013 (MS2) Outstanding Teaching Award 2010-2011
    UT Southwestern Medical Center (2011)
  • Top Doctor
    U.S. News & World Report (2011)
  • Class of 2013 (MS1) Outstanding Teaching Award in Physiology
    UT Southwestern Medical Center (2010)
  • Disease-Oriented Clinical Scholar
    UT Southwestern Medical Center (2006-2009)
  • Phi Beta Kappa, Phi Kappa Phi, and Golden Key National Honor Societies
    Cornell University (1989)

Professional Associations/Affiliations

  • Society for the Study of Ingestive Behavior (2019)
  • American Society for Clinical Investigation (2012)
  • American Thyroid Association (2009)
  • The Endocrine Society (2009)
  • The Obesity Society (2008)
  • American Diabetes Association (2004)
  • American Association of Clinical Endocrinologists (2000)