Biography

Dr. Zigman grew up in New Jersey and performed undergraduate studies at Cornell University. He obtained a dual M.D.-Ph.D. degree from the University of Chicago and remained in Chicago to complete an Internal Medicine residency. Dr. Zigman next moved to Beth Israel Deaconess Medical Center in Boston, where he completed a fellowship in Endocrinology, Diabetes and Metabolism. It was in Boston, while working under the mentorship of Drs. Joel Elmquist and Jeffrey Garber, where Dr. Zigman’s research interests in the hormone ghrelin and the CNS control of eating, body weight, and blood glucose and where his clinical interests in thyroid nodular disease and thyroid cancer first arose.

Dr. Zigman is a Professor of Internal Medicine at UT Southwestern, where he is affiliated with the Division of Hypothalamic Research and the Division of Endocrinology & Metabolism. He holds a secondary appointment in the Department of Psychiatry and also is affiliated with the Neuroscience Graduate Program. Dr. Zigman is the Chair of the Molecular Metabolism and Metabolic Diseases (3MD) Graduate Track which will formally begin in the Fall 2021.

Dr. Zigman’s clinic primarily focuses on the treatment of individuals with thyroid nodules and thyroid cancer.

Dr. Zigman’s research is geared toward understanding the neuro-hormonal framework underlying metabolism. In particular, the Zigman lab focuses on how gastrointestinal hormones such as ghrelin interact with the brain, peripheral nervous system, and various peripheral organs to control eating, body weight, blood glucose, responses to exercise, and mood. Conditions studied by the lab include obesity, diabetes, hypoglycemia, cachexia, Prader-Willi Syndrome, and depression.

Education

Medical School
University of Chicago Pritzker School of Medicine (1997)
Internship/Residency
University of Chicago Hospitals (2000), Internal Medicine
Fellowship
Beth Israel Deaconess Medical Center (2003), Endocrinology & Metabolism

Research Interest

  • Brain-gut axis
  • Cancer cachexia
  • Diabetes and hypoglycemia
  • Enteroendocrine cell function
  • Ghrelin secretion and ghrelin action
  • Metabolic responses to Excercise
  • Neuro-hormonal framework linking complex eating behaviors to mood
  • Obesity and eating behavior
  • Prader-Willi Syndrome

Publications

Featured Publications LegendFeatured Publications

The P7C3 class of neuroprotective compounds exerts antidepressant efficacy in mice by increasing hippocampal neurogenesis.
Walker AK, Rivera PD, Wang Q, Chuang JC, Tran S, Osborne-Lawrence S, Estill SJ, Starwalt R, Huntington P, Morlock L, Naidoo J, Williams NS, Ready JM, Eisch AJ, Pieper AA, Zigman JM Mol. Psychiatry 2014 Apr
The central nervous system sites mediating the orexigenic actions of ghrelin.
Mason BL, Wang Q, Zigman JM Annu. Rev. Physiol. 2014 Feb 76 519-33
Arcuate AgRP neurons mediate orexigenic and glucoregulatory actions of ghrelin.
Wang Q, Liu C, Uchida A, Chuang JC, Walker A, Liu T, Osborne-Lawrence S, Mason BL, Mosher C, Berglund ED, Elmquist JK, Zigman JM Mol Metab 2014 Feb 3 1 64-72
Estradiol modulates Kiss1 Neuronal Response to Ghrelin.
Frazao R, Dungan-Lemko H, Silva RP, Ratra DV, Lee CE, Williams KW, Zigman JM, Elias CF Am. J. Physiol. Endocrinol. Metab. 2014 Jan
G protein-coupled receptor 120 signaling regulates ghrelin secretion in vivo and in vitro.
Gong Z, Yoshimura M, Aizawa S, Kurotani R, Zigman JM, Sakai T, Sakata I Am. J. Physiol. Endocrinol. Metab. 2014 Jan 306 1 E28-35
Role of calcium and EPAC in norepinephrine-induced ghrelin secretion.
Mani BK, Chuang JC, Kjalarsdottir L, Sakata I, Walker AK, Kuperman A, Osborne-Lawrence S, Repa JJ, Zigman JM Endocrinology 2014 Jan 155 1 98-107
Analysis of brain nuclei accessible to ghrelin present in the cerebrospinal fluid.
Cabral A, Fernandez G, Perello M Neuroscience 2013 Dec 253 406-15
An eGFP-expressing subpopulation of growth hormone secretagogue receptor cells are distinct from kisspeptin, tyrosine hydroxylase, and RFamide-related peptide neurons in mice.
Smith JT, Reichenbach A, Lemus M, Mani BK, Zigman JM, Andrews ZB Peptides 2013 Jul 47C 45-53
Shift in Kiss1 Cell Activity Requires Estrogen Receptor a.
Frazão R, Cravo RM, Donato J, Ratra DV, Clegg DJ, Elmquist JK, Zigman JM, Williams KW, Elias CF J. Neurosci. 2013 Feb 33 7 2807-20
Differential effects of chronic social stress and fluoxetine on meal patterns in mice.
Kumar J, Chuang JC, Na ES, Kuperman A, Gillman AG, Mukherjee S, Zigman JM, McClung CA, Lutter M Appetite 2013 Jan 64C 81-88

Books

Featured Books Legend Featured Books

Obesity. In Pocket Primary Care

Zigman J (2001). Philadelphia, Lippincott, Williams, & Wilkins

Mechanisms of homeostatically regulated behaviors. In Neuroscience in the 21st Century

Elmquist J, Zigman J, Saper C. (2011). Berlin, Springer-Verlag GmbH

Honors & Awards

  • Election to the Association of American Physicians
    (2021)
  • Ken and Jodi Foster Distinguished Chair in Endocrinology, in Honor of Daniel Foster, M.D.
    UT Southwestern Medical Center (2016)
  • Top Doctor
    Castle Connolly (2015)
  • Patricia Usher Memorial Lecture Speaker
    Beth Israel Deaconess Medical Center (2014)
  • Class of 2014 (MS2) Outstanding Teaching Award
    UT Southwestern Medical Center (2012)
  • Election to the American Society for Clinical Investigation
    (2012)
  • Mr. and Mrs. Bruce G. Brookshire Professorship in Medicine
    UT Southwestern Medical Center (2012)
  • The Diana and Richard C. Strauss Professorship in Biomedical Research
    UT Southwestern Medical Center (2012)
  • Class of 2013 (MS2) Outstanding Teaching Award 2010-2011
    UT Southwestern Medical Center (2011)
  • Top Doctor
    U.S. News & World Report (2011)
  • Class of 2013 (MS1) Outstanding Teaching Award in Physiology
    UT Southwestern Medical Center (2010)
  • Disease-Oriented Clinical Scholar
    UT Southwestern Medical Center (2006-2009)
  • Phi Beta Kappa, Phi Kappa Phi, and Golden Key National Honor Societies
    Cornell University (1989)

Professional Associations/Affiliations

  • Association of American Physicians (2021)
  • Society for the Study of Ingestive Behavior (2019)
  • American Society for Clinical Investigation (2012)
  • American Thyroid Association (2009)
  • The Endocrine Society (2009)
  • The Obesity Society (2008)
  • American Diabetes Association (2004)
  • American Association of Clinical Endocrinologists (2000)