Biography

Dr. Zigman grew up in New Jersey and performed undergraduate studies at Cornell University. He obtained a dual M.D.-Ph.D. degree from the University of Chicago and remained in Chicago to complete an Internal Medicine residency. Dr. Zigman next moved to Beth Israel Deaconess Medical Center in Boston, where he completed a fellowship in Endocrinology, Diabetes and Metabolism. It was in Boston, while working under the mentorship of Drs. Joel Elmquist and Jeffrey Garber, where Dr. Zigman’s research interests in the hormone ghrelin and the CNS control of eating, body weight, and blood glucose and where his clinical interests in thyroid nodular disease and thyroid cancer first arose.

Dr. Zigman is a Professor of Internal Medicine at UT Southwestern, where he is affiliated with the Division of Hypothalamic Research and the Division of Endocrinology & Metabolism. He holds a secondary appointment in the Department of Psychiatry and also is affiliated with the Neuroscience Graduate Program. Dr. Zigman is the Chair of the Molecular Metabolism and Metabolic Diseases (3MD) Graduate Track which will formally begin in the Fall 2021.

Dr. Zigman’s clinic primarily focuses on the treatment of individuals with thyroid nodules and thyroid cancer.

Dr. Zigman’s research is geared toward understanding the neuro-hormonal framework underlying metabolism. In particular, the Zigman lab focuses on how gastrointestinal hormones such as ghrelin interact with the brain, peripheral nervous system, and various peripheral organs to control eating, body weight, blood glucose, responses to exercise, and mood. Conditions studied by the lab include obesity, diabetes, hypoglycemia, cachexia, Prader-Willi Syndrome, and depression.

Education

Medical School
University of Chicago Pritzker School of Medicine (1997)
Internship/Residency
University of Chicago Hospitals (2000), Internal Medicine
Fellowship
Beth Israel Deaconess Medical Center (2003), Endocrinology & Metabolism

Research Interest

  • Brain-gut axis
  • Cancer cachexia
  • Diabetes and hypoglycemia
  • Enteroendocrine cell function
  • Ghrelin secretion and ghrelin action
  • Metabolic responses to Excercise
  • Neuro-hormonal framework linking complex eating behaviors to mood
  • Obesity and eating behavior
  • Prader-Willi Syndrome

Publications

Featured Publications LegendFeatured Publications

Ghrelin activates hypophysiotropic corticotropin-releasing factor neurons independently of the arcuate nucleus.
Cabral A, Portiansky E, Sánchez-Jaramillo E, Zigman JM, Perello M Psychoneuroendocrinology 2016 Feb 67 27-39
A Strong Stomach for Somatostatin.
Mani BK, Zigman JM Endocrinology 2015 Nov 156 11 3876-9
Obesity Impairs the Action of the Neuroendocrine Ghrelin System.
Zigman JM, Bouret SG, Andrews ZB Trends Endocrinol. Metab. 2015 Nov
Research Resource: A Chromogranin A Reporter for Serotonin and Histamine Secreting Enteroendocrine Cells.
Engelstoft MS, Lund ML, Grunddal KV, Egerod KL, Osborne-Lawrence S, Seier Poulsen S, Zigman JM, Schwartz TW Mol. Endocrinol. 2015 Sep me20151106
Ghrelin.
Müller TD, Nogueiras R, Andermann ML, Andrews ZB, Anker SD, Argente J, Batterham RL, Benoit SC, Bowers CY, Broglio F, Casanueva FF, D'Alessio D, Depoortere I, Geliebter A, Ghigo E, Cole PA, Cowley M, Cummings DE, Dagher A, Diano S, Dickson SL, Diéguez C, Granata R, Grill HJ, Grove K, Habegger KM, Heppner K, Heiman ML, Holsen L, Holst B, Inui A, Jansson JO, Kirchner H, Korbonits M, Laferrère B, LeRoux CW, Lopez M, Morin S, Nakazato M, Nass R, Perez-Tilve D, Pfluger PT, Schwartz TW, Seeley RJ, Sleeman M, Sun Y, Sussel L, Tong J, Thorner MO, van der Lely AJ, van der Ploeg LH, Zigman JM, Kojima M, Kangawa K, Smith RG, Horvath T, Tschöp MH Mol Metab 2015 Jun 4 6 437-60
Neuroanatomical and functional characterization of CRF neurons of the amygdala using a novel transgenic mouse model.
De Francesco PN, Valdivia S, Cabral A, Reynaldo M, Raingo J, Sakata I, Osborne-Lawrence S, Zigman JM, Perelló M Neuroscience 2015 Jan 289C 153-165
Novel Regulator of Acylated Ghrelin, CF801, Reduces Weight Gain, Rebound Feeding after a Fast, and Adiposity in Mice.
Wellman MK, Patterson ZR, MacKay H, Darling JE, Mani BK, Zigman JM, Hougland JL, Abizaid A Front Endocrinol (Lausanne) 2015 6 144
Altered ghrelin secretion in mice in response to diet-induced obesity and Roux-en-Y gastric bypass.
Uchida A, Zechner JF, Mani BK, Park WM, Aguirre V, Zigman JM Mol Metab 2014 Oct 3 7 717-30
Divergent neuronal circuitries underlying acute orexigenic effects of peripheral or central ghrelin: critical role of brain accessibility.
Cabral A, Valdivia S, Fernandez G, Reynaldo M, Perello M J. Neuroendocrinol. 2014 Aug 26 8 542-54
Neuroanatomical characterization of a growth hormone secretagogue receptor-green fluorescent protein reporter mouse.
Mani BK, Walker AK, LopezSoto EJ, Raingo J, Lee CE, Perelló M, Andrews ZB, Zigman JM J. Comp. Neurol. 2014 May

Books

Featured Books Legend Featured Books

Obesity. In Pocket Primary Care

Zigman J (2001). Philadelphia, Lippincott, Williams, & Wilkins

Mechanisms of homeostatically regulated behaviors. In Neuroscience in the 21st Century

Elmquist J, Zigman J, Saper C. (2011). Berlin, Springer-Verlag GmbH

Honors & Awards

  • Election to the Association of American Physicians
    (2021)
  • Ken and Jodi Foster Distinguished Chair in Endocrinology, in Honor of Daniel Foster, M.D.
    UT Southwestern Medical Center (2016)
  • Top Doctor
    Castle Connolly (2015)
  • Patricia Usher Memorial Lecture Speaker
    Beth Israel Deaconess Medical Center (2014)
  • Class of 2014 (MS2) Outstanding Teaching Award
    UT Southwestern Medical Center (2012)
  • Election to the American Society for Clinical Investigation
    (2012)
  • Mr. and Mrs. Bruce G. Brookshire Professorship in Medicine
    UT Southwestern Medical Center (2012)
  • The Diana and Richard C. Strauss Professorship in Biomedical Research
    UT Southwestern Medical Center (2012)
  • Class of 2013 (MS2) Outstanding Teaching Award 2010-2011
    UT Southwestern Medical Center (2011)
  • Top Doctor
    U.S. News & World Report (2011)
  • Class of 2013 (MS1) Outstanding Teaching Award in Physiology
    UT Southwestern Medical Center (2010)
  • Disease-Oriented Clinical Scholar
    UT Southwestern Medical Center (2006-2009)
  • Phi Beta Kappa, Phi Kappa Phi, and Golden Key National Honor Societies
    Cornell University (1989)

Professional Associations/Affiliations

  • Association of American Physicians (2021)
  • Society for the Study of Ingestive Behavior (2019)
  • American Society for Clinical Investigation (2012)
  • American Thyroid Association (2009)
  • The Endocrine Society (2009)
  • The Obesity Society (2008)
  • American Diabetes Association (2004)
  • American Association of Clinical Endocrinologists (2000)