Jeffrey Zigman, M.D., Ph.D. Professor Endowed Title Kent and Jodi Foster Distinguished Chair in Endocrinology, in Honor of Daniel Foster, M.D.; Mr. and Mrs. Bruce G. Brookshire Professorship in Medicine; The Diana and Richard C. Strauss Professorship in Biomedical Research School Medical School Department Internal Medicine | Psychiatry Graduate Programs Genetics, Development and Disease, Neuroscience You have reached the Academic Profile. For more information on the doctor and patient care, please visit the clinical profile. Biography Jeffrey Zigman, M.D., Ph.D., is a Professor with tenure in the Department of Internal Medicine at UT Southwestern Medical Center and a member of the Division of Endocrinology. He has a secondary appointment in the Department of Psychiatry. He holds the Kent and Jodi Foster Distinguished Chair in Endocrinology, the Diane and Richard C. Strauss Professorship in Biomedical Research, and the Mr. and Mrs. Bruce G Brookshire Professorship in Medicine. Originally from Bradford, Pennsylvania, Dr. Zigman holds a bachelor's degree in biological sciences from Cornell University in Ithaca, New York. He earned his doctorate in biochemistry and molecular biology at the University of Chicago. He earned his medical degree at the University of Chicago School of Medicine. He completed internal medicine residency training at the University of Chicago. He then received advanced training through a clinical and research fellowship in endocrinology, diabetes, and metabolism under Dr. Joel Elmquist and Dr. Jeffrey Garber at Beth Israel Deaconess Medical Center in Boston. A Diplomate of the American Board of Internal Medicine, Dr. Zigman joined the UT Southwestern faculty in 2006. At UT Southwestern, Dr. Zigman is Chair of the Molecular Metabolism & Metabolic Diseases Graduate Track. He is also the Director of the Enrichment Program at the UT Southwestern Nutrition and Obesity Research Center. Education Medical School University of Chicago Pritzker School of Medicine (1997) Residency University of Chicago Hospitals (2000), Internal Medicine Fellowship Beth Israel Deaconess Medical Center (2003), Endocrinology & Metabolism Research Interest Amyotrophic Lateral Sclerosis Brain-gut axis Cancer cachexia Diabetes and hypoglycemia Enteroendocrine cell function Ghrelin secretion and ghrelin action Islet Biology Metabolic responses to Excercise Neuro-hormonal framework linking complex eating behaviors to mood Obesity and eating behavior Publications Featured Publications Ghrelin cell-expressed insulin receptors mediate meal- and obesity-induced declines in plasma ghrelin. Shankar K, Takemi S, Gupta D, Varshney S, Mani BK, Osborne-Lawrence S, Metzger NP, Richard CP, Berglund ED, Zigman JM, JCI Insight 2021 Sep 6 18 LEAP2 deletion in mice enhances ghrelin's actions as an orexigen and growth hormone secretagogue. Shankar K, Metzger NP, Singh O, Mani BK, Osborne-Lawrence S, Varshney S, Gupta D, Ogden SB, Takemi S, Richard CP, Nandy K, Liu C, Zigman JM, Mol Metab 2021 Aug 101327 "A LEAP 2 conclusions? Targeting the ghrelin system to treat obesity and diabetes". Gupta D, Ogden SB, Shankar K, Varshney S, Zigman JM, Mol Metab 2020 Nov 101128 Acyl-ghrelin is Permissive for the Normal Counterregulatory Response to Insulin-induced Hypoglycemia. Shankar K, Gupta D, Mani BK, Findley BG, Lord CC, Osborne-Lawrence S, Metzger NP, Pietra C, Liu C, Berglund ED, Zigman JM, Diabetes 2019 Nov LEAP2 changes with body mass and food intake in humans and mice. Mani BK, Puzziferri N, He Z, Rodriguez JA, Osborne-Lawrence S, Metzger NP, Chhina N, Gaylinn B, Thorner MO, Thomas EL, Bell JD, Williams KW, Goldstone AP, Zigman JM, J. Clin. Invest. 2019 Aug Ghrelin mediates exercise endurance and the feeding response post-exercise. Mani BK, Castorena CM, Osborne-Lawrence S, Vijayaraghavan P, Metzger NP, Elmquist JK, Zigman JM Mol Metab 2018 Jan Ghrelin as a Survival Hormone. Mani BK, Zigman JM Trends Endocrinol. Metab. 2017 Dec 28 12 843-854 The role of ghrelin-responsive mediobasal hypothalamic neurons in mediating feeding responses to fasting. Mani BK, Osborne-Lawrence S, Mequinion M, Lawrence S, Gautron L, Andrews ZB, Zigman JM Mol Metab 2017 Aug 6 8 882-896 ß1-Adrenergic receptor deficiency in ghrelin-expressing cells causes hypoglycemia in susceptible individuals Mani BK, Osborne-Lawrence S, Vijayaraghavan P, Hepler C, Zigman JM J. Clin. Invest. 2016 Sep 126 9 3467-3478 Ghrelin mediates stress-induced food-reward behavior in mice. Chuang JC, Perello M, Sakata I, Osborne-Lawrence S, Savitt JM, Lutter M, Zigman JM J. Clin. Invest. 2011 Jul 121 7 2684-92 Results 1-10 of 103 1 2 3 4 5 Next Last Books Featured Books Obesity. In Pocket Primary Care Zigman J (2001). Philadelphia, Lippincott, Williams, & Wilkins Mechanisms of homeostatically regulated behaviors. In Neuroscience in the 21st Century Elmquist J, Zigman J, Saper C. (2011). Berlin, Springer-Verlag GmbH Honors & Awards Election to the Association of American Physicians (2021) Ken and Jodi Foster Distinguished Chair in Endocrinology, in Honor of Daniel Foster, M.D.UT Southwestern Medical Center (2016) Top DoctorCastle Connolly (2015) Patricia Usher Memorial Lecture SpeakerBeth Israel Deaconess Medical Center (2014) Class of 2014 (MS2) Outstanding Teaching AwardUT Southwestern Medical Center (2012) Election to the American Society for Clinical Investigation (2012) Mr. and Mrs. Bruce G. Brookshire Professorship in MedicineUT Southwestern Medical Center (2012) The Diana and Richard C. Strauss Professorship in Biomedical ResearchUT Southwestern Medical Center (2012) Class of 2013 (MS2) Outstanding Teaching Award 2010-2011UT Southwestern Medical Center (2011) Top DoctorU.S. News & World Report (2011) Class of 2013 (MS1) Outstanding Teaching Award in PhysiologyUT Southwestern Medical Center (2010) Disease-Oriented Clinical ScholarUT Southwestern Medical Center (2006-2009) Phi Beta Kappa, Phi Kappa Phi, and Golden Key National Honor SocietiesCornell University (1989) Professional Associations/Affiliations American Association of Clinical Endocrinologists (2000) American Diabetes Association (2004) American Society for Clinical Investigation (2012) American Thyroid Association (2009) Association of American Physicians (2021) Society for the Study of Ingestive Behavior (2019) The Endocrine Society (2009) The Obesity Society (2008)
