Elizabeth Maher, M.D., Ph.D.

Other Post Graduate Training

McGill University Faculty of Medicine (1989)

Graduate School

McGill University Faculty of Medicine (1989), Physiology

Medical School

McGill University Faculty of Medicine (1993)

Internship/Residency

University of Toronto Hospitals, Canada (1996), Internal Medicine

Fellowship

Dana-Farber Cancer Institute (1999), Hematology Oncology

• Development of improved imaging techniques for brain tumors
• Primary and metastatic brain tumors
• Role of altered metabolism in the progression of malignant gliomas.

Featured Publications

Oncogenes Activate an Autonomous Transcriptional Regulatory Circuit That Drives Glioblastoma.

Singh DK, Kollipara RK, Vemireddy V, Yang XL, Sun Y, Regmi N, Klingler S, Hatanpaa KJ, Raisanen J, Cho SK, Sirasanagandla S, Nannepaga S, Piccirillo S, Mashimo T, Wang S, Humphries CG, Mickey B, Maher EA, Zheng H, Kim RS, Kittler R, Bachoo RM Cell Rep 2017 Jan 18 4 961-976

Prospective Longitudinal Analysis of 2-Hydroxyglutarate Magnetic Resonance Spectroscopy Identifies Broad Clinical Utility for the Management of Patients With IDH-Mutant Glioma.

Choi C, Raisanen JM, Ganji SK, Zhang S, McNeil SS, An Z, Madan A, Hatanpaa KJ, Vemireddy V, Sheppard CA, Oliver D, Hulsey KM, Tiwari V, Mashimo T, Battiste J, Barnett S, Madden CJ, Patel TR, Pan E, Malloy CR, Mickey BE, Bachoo RM, Maher EA J. Clin. Oncol. 2016 Nov 34 33 4030-4039

Hepatic gluconeogenesis influences (13)C enrichment in lactate in human brain tumors during metabolism of [1,2-(13)C]acetate.

Pichumani K, Mashimo T, Vemireddy V, Kovacs Z, Ratnakar J, Mickey B, Malloy CR, DeBerardinis RJ, Bachoo RM, Maher EA Neurochem. Int. 2016 Mar

Acetate is a bioenergetic substrate for human glioblastoma and brain metastases.

Mashimo T, Pichumani K, Vemireddy V, Hatanpaa KJ, Singh DK, Sirasanagandla S, Nannepaga S, Piccirillo SG, Kovacs Z, Foong C, Huang Z, Barnett S, Mickey BE, DeBerardinis RJ, Tu BP, Maher EA, Bachoo RM Cell 2014 Dec 159 7 1603-14

Metabolism of [U-13 C]glucose in human brain tumors in vivo.

Maher EA, Marin-Valencia I, Bachoo RM, Mashimo T, Raisanen J, Hatanpaa KJ, Jindal A, Jeffrey FM, Choi C, Madden C, Mathews D, Pascual JM, Mickey BE, Malloy CR, DeBerardinis RJ NMR Biomed 2012 Nov 25 11 1234-44

Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse human glioblastomas in the mouse brain in vivo.

Marin-Valencia I, Yang C, Mashimo T, Cho S, Baek H, Yang XL, Rajagopalan KN, Maddie M, Vemireddy V, Zhao Z, Cai L, Good L, Tu BP, Hatanpaa KJ, Mickey BE, Matés JM, Pascual JM, Maher EA, Malloy CR, Deberardinis RJ, Bachoo RM Cell Metab. 2012 Jun 15 6 827-37

2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas.

Choi C, Ganji SK, DeBerardinis RJ, Hatanpaa KJ, Rakheja D, Kovacs Z, Yang XL, Mashimo T, Raisanen JM, Marin-Valencia I, Pascual JM, Madden CJ, Mickey BE, Malloy CR, Bachoo RM, Maher EA Nat. Med. 2012 Apr 18 4 624-9

Improvement of resolution for brain coupled metabolites by optimized (1)H MRS at 7T.

Choi C, Dimitrov IE, Douglas D, Patel A, Kaiser LG, Amezcua CA, Maher EA NMR Biomed 2010 Nov 23 9 1044-52

Brain metastasis: opportunities in basic and translational research.

Maher EA, Mietz J, Arteaga CL, DePinho RA, Mohla S Cancer Res. 2009 Aug 69 15 6015-20

Marked genomic differences characterize primary and secondary glioblastoma subtypes and identify two distinct molecular and clinical secondary glioblastoma entities.

Maher EA, Brennan C, Wen PY, Durso L, Ligon KL, Richardson A, Khatry D, Feng B, Sinha R, Louis DN, Quackenbush J, Black PM, Chin L, DePinho RA Cancer Res. 2006 Dec 66 23 11502-13

• Society for Neuro-Oncology (2003)
• American Society of Clinical Oncology (2001)