Biography

Dr. Robert Bachoo is a physician-scientist in the Department of Neurology and Neurotherapeutics and holds joint appointments in the Department of Internal Medicine and the Simmons Comprehensive Cancer Center. He leads the Neuro-Oncology Translational Laboratory in the Simmons Comprehensive Cancer Center, coordinating multidisciplinary basic, translational, and clinical brain tumor-related research.

Dr. Bachoo received his MD from the University of Toronto (Ontario, Canada) and his PhD from McGill University (Quebec, Canada). He completed his Neurology training at Tufts University, Boston, where he served as the Chief Resident in Neurology. Following his clinical training, he joined Dr. Ronald Depinho’s laboratory at Dana Farber Cancer Institute, Harvard University, Boston, as a post-doctoral research fellow, while serving as a Clinical Instructor in Neurology Brigham and Women’s Hospital, Harvard University. Dr. Bachoo joined the faculty of Neurology and Neurotherapeutics at UT Southwestern Medical Center in 2006 and was named the Miller Family Professor in Neuro-Oncology.

Dr. Bachoo’s research focuses on understanding the fundamental mechanisms that drive malignant brain tumors. A major emphasis of his work is developing accurate models of brain tumors, which include using genetically engineered mouse glioma models (GEMMs) as well as patient-derived xenograft (PDX) models from patients undergoing surgical resection of their tumor at UT Southwestern. His laboratory has generated one of the largest collections of brain tumor PDX models in the country and has pioneered the intra-operative metabolic tracer studies in brain tumor patients undergoing surgery for studying tumor metabolism. These clinically and molecularly annotated mouse models serve as critical discovery platforms to understand fundamental mechanisms that drive brain growth and identify potential therapeutic vulnerabilities. Insights gained from the models have contributed to overturning an 80-year-old dogma about how brain tumors fuel their growth as well as identified novel clinical imaging biomarkers and potential therapeutic targets. In addition to fostering multidisciplinary collaborative research at UTSW, Dr. Bachoo has developed strong inter-institutional collaborations with faculty in the Departments of Biomedical Engineering and Mechanical Engineering (UT Arlington and UT Dallas). Together, his research teams use biophysical approaches to understand how brain tumor cells migrate through the brain tissue, a characteristic which makes these tumors surgically incurable. These projects aim to develop novel strategies to safely and reversibly disrupt the blood-brain-barrier for drug delivery.

Dr. Bachoo has authored more than 100 scientific peer-reviewed articles and is reviewer for more than 20 journals.  He has served on multiple NIH research study sections, including as a permanent member of the Cellular and Molecular Biology of Glia (CMBG), and on Special Emphasis Panels, including the Cancer Atlas.

Education

Graduate School
McGill University Faculty of Medicine (1989), Experimental Medicine
Medical School
University of Toronto (1996), Medicine
Internship
Brigham and Women's Hospital/The Faulkner Hospital (1997), Neurology
Residency
Tufts University (2000), Neurology

Research Interest

  • Blood Brain Barrier Disruption
  • Brain Tumor Metabolism
  • Malignant Transformation
  • Stem Cell Biology
  • Tumor Cell Migration
  • Tumor Microenvironment

Publications

Featured Publications LegendFeatured Publications

Conditions for (13)C NMR Detection of 2-Hydroxyglutarate in Tissue Extracts from IDH-Mutated Gliomas.
Pichumani K, Mashimo T, Baek HM, Ratnakar J, Mickey B, DeBerardinis RJ, Maher EA, Bachoo RM, Malloy CR, Kovacs Z Anal. Biochem. 2015 Apr
(1) H MRS characterization of neurochemical profiles in orthotopic mouse models of human brain tumors.
Hulsey KM, Mashimo T, Banerjee A, Soesbe TC, Spence JS, Vemireddy V, Maher EA, Bachoo RM, Choi C NMR Biomed 2014 Nov
Proton T2 measurement and quantification of lactate in brain tumors by MRS at 3 Tesla in vivo.
Madan A, Ganji SK, An Z, Choe KS, Pinho MC, Bachoo RM, Maher EM, Choi C Magn Reson Med 2014 Jul
In vivo chemical exchange saturation transfer imaging allows early detection of a therapeutic response in glioblastoma.
Sagiyama K, Mashimo T, Togao O, Vemireddy V, Hatanpaa KJ, Maher EA, Mickey BE, Pan E, Sherry AD, Bachoo RM, Takahashi M Proc. Natl. Acad. Sci. U.S.A. 2014 Mar 111 12 4542-7
DNA double-strand breaks cooperate with loss of Ink4 and Arf tumor suppressors to generate glioblastomas with frequent Met amplification.
Camacho CV, Todorova PK, Hardebeck MC, Tomimatsu N, Gil Del Alcazar CR, Ilcheva M, Mukherjee B, McEllin B, Vemireddy V, Hatanpaa K, Story MD, Habib AA, Murty VV, Bachoo R, Burma S Oncogene 2014 Mar
High expression of the stem cell marker nestin is an adverse prognostic factor in WHO grade II-III astrocytomas and oligoastrocytomas.
Hatanpaa KJ, Hu T, Vemireddy V, Foong C, Raisanen JM, Oliver D, Hiemenz MC, Burns DK, White CL, Whitworth LA, Mickey B, Stegner M, Habib AA, Fink K, Maher EA, Bachoo RM J. Neurooncol. 2014 Mar 117 1 183-9
Inhibition of DNA Double-Strand Break Repair by the Dual PI3K/mTOR Inhibitor NVP-BEZ235 as a Strategy for Radiosensitization of Glioblastoma.
Gil Del Alcazar CR, Hardebeck MC, Mukherjee B, Tomimatsu N, Gao X, Yan J, Xie XJ, Bachoo R, Li L, Habib AA, Burma S Clin. Cancer Res. 2014 Feb
In vivo detection of citrate in brain tumors by (1) H magnetic resonance spectroscopy at 3T.
Choi C, Ganji SK, Madan A, Hulsey KM, An Z, Zhang S, Pinho MC, Deberardinis RJ, Bachoo RM, Maher EA Magn Reson Med 2013 Oct
2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas.
Choi C, Ganji SK, DeBerardinis RJ, Hatanpaa KJ, Rakheja D, Kovacs Z, Yang XL, Mashimo T, Raisanen JM, Marin-Valencia I, Pascual JM, Madden CJ, Mickey BE, Malloy CR, Bachoo RM, Maher EA Nat. Med. 2012 Apr 18 4 624-9
Suppression of reactive oxygen species and MPTP-induced neurodegenration by the PGC-1 transcriptional coactivator
St-Pierre, J., Droir, S., Uldry, M., Rhee, J., Lin, J, Handshin, C., Yang, W., Bachoo,R., Spigelman,BM Cell 127(2):397-408. October 2006 127 (2) 397-408.

Books

Featured Books Legend Featured Books

Glioblastoma. In Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease

Maher E, Bachoo, R (2014). San Diego, Elsevier

Honors & Awards

  • American Society of Clinical Investigation
    Poster presentation award (2002)
  • Chief Resident
    Tufts University Neurology Program (1999-2000)
  • Medical Research Council of Canada Medical Scientist
    (1994-1996)
  • Heart and Stroke Foundation of Canada Medical Scientist
    (1992-1994)
  • McGill University
    Ph.D. with Honors (1989)

Professional Associations/Affiliations

  • American Academy of Neurology (2011)
  • American Association for Cancer Research (2006)
  • American Society of Neuro-Oncology (2002)
  • American Society of Neurology (2000)