Biography

Dr. Robert Bachoo is a physician-scientist in the Department of Neurology and Neurotherapeutics and holds joint appointments in the Department of Internal Medicine and the Simmons Comprehensive Cancer Center. He leads the Neuro-Oncology Translational Laboratory in the Simmons Comprehensive Cancer Center, coordinating multidisciplinary basic, translational, and clinical brain tumor-related research.

Dr. Bachoo received his MD from the University of Toronto (Ontario, Canada) and his PhD from McGill University (Quebec, Canada). He completed his Neurology training at Tufts University, Boston, where he served as the Chief Resident in Neurology. Following his clinical training, he joined Dr. Ronald Depinho’s laboratory at Dana Farber Cancer Institute, Harvard University, Boston, as a post-doctoral research fellow, while serving as a Clinical Instructor in Neurology Brigham and Women’s Hospital, Harvard University. Dr. Bachoo joined the faculty of Neurology and Neurotherapeutics at UT Southwestern Medical Center in 2006 and was named the Miller Family Professor in Neuro-Oncology.

Dr. Bachoo’s research focuses on understanding the fundamental mechanisms that drive malignant brain tumors. A major emphasis of his work is developing accurate models of brain tumors, which include using genetically engineered mouse glioma models (GEMMs) as well as patient-derived xenograft (PDX) models from patients undergoing surgical resection of their tumor at UT Southwestern. His laboratory has generated one of the largest collections of brain tumor PDX models in the country and has pioneered the intra-operative metabolic tracer studies in brain tumor patients undergoing surgery for studying tumor metabolism. These clinically and molecularly annotated mouse models serve as critical discovery platforms to understand fundamental mechanisms that drive brain growth and identify potential therapeutic vulnerabilities. Insights gained from the models have contributed to overturning an 80-year-old dogma about how brain tumors fuel their growth as well as identified novel clinical imaging biomarkers and potential therapeutic targets. In addition to fostering multidisciplinary collaborative research at UTSW, Dr. Bachoo has developed strong inter-institutional collaborations with faculty in the Departments of Biomedical Engineering and Mechanical Engineering (UT Arlington and UT Dallas). Together, his research teams use biophysical approaches to understand how brain tumor cells migrate through the brain tissue, a characteristic which makes these tumors surgically incurable. These projects aim to develop novel strategies to safely and reversibly disrupt the blood-brain-barrier for drug delivery.

Dr. Bachoo has authored more than 100 scientific peer-reviewed articles and is reviewer for more than 20 journals.  He has served on multiple NIH research study sections, including as a permanent member of the Cellular and Molecular Biology of Glia (CMBG), and on Special Emphasis Panels, including the Cancer Atlas.

Education

Graduate School
McGill University Faculty of Medicine (1989), Experimental Medicine
Medical School
University of Toronto (1996), Medicine
Internship
Brigham and Women's Hospital/The Faulkner Hospital (1997), Neurology
Residency
Tufts University (2000), Neurology

Research Interest

  • Blood Brain Barrier Disruption
  • Brain Tumor Metabolism
  • Malignant Transformation
  • Stem Cell Biology
  • Tumor Cell Migration
  • Tumor Microenvironment

Publications

Featured Publications LegendFeatured Publications

In vivo MRS measurement of 2-hydroxyglutarate in patient-derived IDH-mutant xenograft mouse models versus glioma patients.
Tiwari V, Mashimo T, An Z, Vemireddy V, Piccirillo S, Askari P, Hulsey KM, Zhang S, de Graaf RA, Patel TR, Pan E, Mickey BE, Maher EA, Bachoo RM, Choi C, Magn Reson Med 2020 Jan
Radiation-induced DNA damage cooperates with heterozygosity of TP53 and PTEN to generate high grade gliomas.
Todorova PK, Fletcher-Sananikone E, Mukherjee B, Kollipara R, Vemireddy V, Xie XJ, Guida PM, Story MD, Hatanpaa K, Habib AA, Kittler R, Bachoo R, Hromas R, Floyd JR, Burma S, Cancer Res. 2019 May
Measurement of (13) C turnover into glutamate and glutamine pools in brain tumor patients.
Pichumani K, Mashimo T, Vemireddy V, Ijare OB, Mickey BE, Malloy CR, Marin-Valencia I, Baskin DS, Bachoo RM, Maher EA FEBS Lett. 2017 Sep
Rapid progression to glioblastoma in a subset of IDH-mutated astrocytomas: a genome-wide analysis.
Richardson TE, Snuderl M, Serrano J, Karajannis MA, Heguy A, Oliver D, Raisanen JM, Maher EA, Pan E, Barnett S, Cai C, Habib AA, Bachoo RM, Hatanpaa KJ J. Neurooncol. 2017 Apr
Targeting orthotopic gliomas with renal-clearable luminescent gold nanoparticles.
Peng C, Gao X, Xu J, Du B, Ning X, Tang S, Bachoo RM, Yu M, Ge WP, Zheng J Nano Res 2017 Apr 10 4 1366-1376
Hepatic gluconeogenesis influences (13)C enrichment in lactate in human brain tumors during metabolism of [1,2-(13)C]acetate.
Pichumani K, Mashimo T, Vemireddy V, Kovacs Z, Ratnakar J, Mickey B, Malloy CR, DeBerardinis RJ, Bachoo RM, Maher EA Neurochem. Int. 2016 Mar
Brain Tumor Genetic Modification Yields Increased Resistance to Paclitaxel in Physical Confinement.
Bui L, Hendricks A, Wright J, Chuong CJ, Davé D, Bachoo R, Kim YT Sci Rep 2016 6 26134
SOX2 Reprograms Resident Astrocytes into Neural Progenitors in the Adult Brain.
Niu W, Zang T, Smith DK, Vue TY, Zou Y, Bachoo R, Johnson JE, Zhang CL Stem Cell Reports 2015 Apr

Books

Featured Books Legend Featured Books

Glioblastoma. In Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease

Maher E, Bachoo, R (2014). San Diego, Elsevier

Honors & Awards

  • American Society of Clinical Investigation
    Poster presentation award (2002)
  • Chief Resident
    Tufts University Neurology Program (1999-2000)
  • Medical Research Council of Canada Medical Scientist
    (1994-1996)
  • Heart and Stroke Foundation of Canada Medical Scientist
    (1992-1994)
  • McGill University
    Ph.D. with Honors (1989)

Professional Associations/Affiliations

  • American Academy of Neurology (2011)
  • American Association for Cancer Research (2006)
  • American Society of Neuro-Oncology (2002)
  • American Society of Neurology (2000)