Biography

Download Curriculum Vitae

POSITIONS:

1993-1994 Undergraduate Research Assistant, Department of Chemistry, Boston College, Newton, MA. Supervisor: Mary Roberts, Ph.D.

1994-1996 Research Assistant, Department of Biochemistry and Molecular Biology, Georgetown University Medical Center, Washington DC. Supervisor: Mark Danielsen, Ph.D.

1996-2002 Graduate Student Research Fellow, Department of Biochemistry and Molecular Biology, Georgetown University Medical Center, Washington, DC. Supervisor/mentor: Mark Danielsen, Ph.D.

2002-2005 Postdoctoral Fellow, Laboratory of Receptor Biology and Gene Expression National Cancer Institute, NIH, Bethesda, MD. Supervisor: Gordon L. Hager, Ph.D.

2005- 2009 Instructor, Department of Pharmacology, UT Southwestern.

Sept. 2009 - 2013 Assistant Professor, Department of Pharmacology, UT Southwestern.

Sept. 2013-2019 Tenure track Assistant Professor, Department of Pharmacology, UT Southwestern.

Sept. 2019- Asoociate Professor, Department of Pharmacology, UT Southwestern (tenured).

Education

Graduate School
Georgetown University (2002)

Research Interest

  • Deregulation of transcriptional pathways in cancer and other diseases
  • Drug discovery
  • Epigenetic control of gene expression
  • Interplay between cellular metabolism and epigenetics
  • Novel therapeutics for gene expression disorders
  • Small molecule inhibitors of Jumonji enzymes
  • The role of Jumonji histone demethylases in physiology and disease
  • Transcriptional regulation by nuclear receptors and their cofactors

Publications

Featured Publications LegendFeatured Publications

Genetic heterogeneity within collective invasion packs drives leader and follower cell phenotypes.
Zoeller EL, Pedro B, Konen J, Dwivedi B, Rupji M, Sundararaman N, Wang L, Horton JR, Zhong C, Barwick BG, Cheng X, Martinez ED, Torres MP, Kowalski J, Marcus AI, Vertino PM, J. Cell. Sci. 2019 Sep
A comprehensive study of epigenetic alterations in hepatocellular carcinoma identifies potential therapeutic targets.
Bayo J, Fiore EJ, Dominguez LM, Real A, Malvicini M, Rizzo M, Atorrasagasti C, García MG, Argemi J, Martinez ED, Mazzolini GD, J. Hepatol. 2019 Mar
Telomerase-Mediated Strategy for Overcoming Non-Small Cell Lung Cancer Targeted Therapy and Chemotherapy Resistance.
Mender I, LaRanger R, Luitel K, Peyton M, Girard L, Lai TP, Batten K, Cornelius C, Dalvi MP, Ramirez M, Du W, Wu LF, Altschuler SJ, Brekken R, Martinez ED, Minna JD, Wright WE, Shay JW Neoplasia 2018 Aug 20 8 826-837
JumonjiC demethylase inhibitors show potential for targeting chemotherapy-resistant lung cancers.
Dalvi MP, Martinez ED Mol Cell Oncol 2017 4 5 e1345352

Honors & Awards

  • John P. Perkins, Ph.D. Distinguished Professor in Biomedical Science
    UTSW (2019-2022)
  • Gliman Special Opportunities Award
    UTSW (2016)
  • Friends of the Cancer Center Award
    UTSW (2014)
  • Dean's LEAD award
    (2013)
  • Early Investigator Abstract award
    Keystone Symposia (2013)
  • Abstract Award
    International Association for the Study of Lung Cancer (2007)
  • NIH Technology Transfer Award
    (2004)
  • NIH FARE Research Excellence Award
    (2003)
  • Keystone Symposia Travel awards
    (2002)
  • Phi Beta Kappa
    1994-present (0)

Professional Associations/Affiliations

  • Co-founder and Member of the Nuclear Receptor Resource Project, 1995-present
  • Member of the American Association for Cancer Research, 2005-present
  • Member of the American Society for Cell Biology, 2004-present
  • Member of the Endocrine Society, 1997-present
  • NIH Task Force on Recruitment and Retention of Women, Subcommittee co-chair, 2003-present