Biography

Download Curriculum Vitae

POSITIONS:

1993-1994 Undergraduate Research Assistant, Department of Chemistry, Boston College, Newton, MA. Supervisor: Mary Roberts, Ph.D.

1994-1996 Research Assistant, Department of Biochemistry and Molecular Biology, Georgetown University Medical Center, Washington DC. Supervisor: Mark Danielsen, Ph.D.

1996-2002 Graduate Student Research Fellow, Department of Biochemistry and Molecular Biology, Georgetown University Medical Center, Washington, DC. Supervisor/mentor: Mark Danielsen, Ph.D.

2002-2005 Postdoctoral Fellow, Laboratory of Receptor Biology and Gene Expression National Cancer Institute, NIH, Bethesda, MD. Supervisor: Gordon L. Hager, Ph.D.

2005- 2009 Instructor, Department of Pharmacology, UT Southwestern.

Sept. 2009 - 2013 Assistant Professor, Department of Pharmacology, UT Southwestern.

Sept. 2013-2019 Tenure track Assistant Professor, Department of Pharmacology, UT Southwestern.

Sept. 2019- Asoociate Professor, Department of Pharmacology, UT Southwestern (tenured).

May 2022- Associate Director of Diversity, Equity and Inclusion, Simmons Comprehensive Cancer Center, UTSW

Education

Graduate School
Georgetown University (2002)

Research Interest

  • Deregulation of transcriptional pathways in cancer and other diseases
  • Drug discovery
  • Epigenetic control of gene expression
  • Interplay between cellular metabolism and epigenetics
  • Novel therapeutics for gene expression disorders
  • Small molecule inhibitors of Jumonji enzymes
  • The role of Jumonji histone demethylases in physiology and disease
  • Transcriptional regulation by nuclear receptors and their cofactors

Publications

Featured Publications LegendFeatured Publications

Epigenetic modulation reveals differentiation state specificity of oncogene addiction.
Khaliq M, Manikkam M, Martinez ED, Fallahi-Sichani M, Nat Commun 2021 03 12 1 1536
A UHPLC-MS/MS method for the quantification of JIB-04 in rat plasma: Development, validation and application to pharmacokinetics study.
Wang Y, Ma J, Martinez ED, Liang D, Xie H, J Pharm Biomed Anal 2020 Nov 191 113587

Honors & Awards

  • John P. Perkins, Ph.D. Distinguished Professor in Biomedical Science
    UTSW (2019-2022)
  • Gliman Special Opportunities Award
    UTSW (2016)
  • Friends of the Cancer Center Award
    UTSW (2014)
  • Dean's LEAD award
    (2013)
  • Early Investigator Abstract award
    Keystone Symposia (2013)
  • Abstract Award
    International Association for the Study of Lung Cancer (2007)
  • NIH Technology Transfer Award
    (2004)
  • NIH FARE Research Excellence Award
    (2003)
  • Keystone Symposia Travel awards
    (2002)
  • Phi Beta Kappa
    1994-present (0)

Professional Associations/Affiliations

  • WISMAC (2020)
  • Co-founder and Member of the Nuclear Receptor Resource Project, 1995-present
  • Member of the American Association for Cancer Research, 2005-present
  • Member of the American Society for Cell Biology, 2004-present
  • Member of the Endocrine Society, 1997-present
  • NIH Task Force on Recruitment and Retention of Women, Subcommittee co-chair, 2003-present